Adult dominant polycystic kidney disease: A prototypical disease for pharmanutrition interventions

Lonardo, Maria Serena; Guida, Bruna; Cacciapuoti, N.; Lauro, Mariastella Di; Cataldi, Mauro

doi:10.1016/j.phanu.2022.100294

Cited by 1 publication

(1 citation statement)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies [45,[50][51][52] have shown that a diet able to induce moderate calorie restriction, such as time-restricted feeding (TRF) or classical intermittent fasting, may be effective in counteracting cyst growth. The first experiment was carried out on animal models of PKD; the results showed that a moderate calorie restriction regime led to a reduction in the size and growth rate of cysts and inflammation levels.…”

Section: Ketogenic Dietmentioning

confidence: 99%

Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature

Capelli,

Lerario,

Aiello

et al. 2023

Nutrients

View full text Add to dashboard Cite

Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients’ daily life. Recently, the literature has been enriched with new works that analyze possible non-pharmacological therapeutic strategies to slow cysts’ enlargement and chronic kidney disease progression. Among them, dietary schemes reducing carbohydrate intake and inducing ketoses have been demonstrated to have efficacy in several pre-clinical and clinical studies. A ketogenic diet, calorie restriction, intermittent fasting, and time-restricted feeding can reduce aerobic glycolysis and inhibit the mTOR pathway, producing a reduction in cyst cell proliferation, a reduction in kidney volume, and helping to preserve kidney function. ADPKD’s burden of disease has an impact on patients’ quality of life, and the possibility to play sports or carry out physical exercise can help people in everyday life. The multisystemic character of the disease, especially cardiovascular involvement, needs to be carefully evaluated to establish the quality and quantity of physical activity that patients can safely carry out.

show abstract

Section: Ketogenic Dietmentioning

confidence: 99%