Adult males with haemophilia have a different macrovascular and microvascular endothelial function profile compared with healthy controls

Abstract

Adult males with haemophilia appear to have lower microvascular endothelial function compared to healthy controls. Future studies to assess the impact of endothelial dysfunction on cardiovascular events in the haemophilia population are needed.

Risk factors for cardiovascular disease in children and young adults with haemophilia

“…Sun et al. conducted a two‐centre prospective cohort study of macro‐ and microvascular endothelial function endothelial dysfunction, an independent predictor of CVD . Microvascular endothelial function was lower in adults with haemophilia compared with controls.…”

Erectile dysfunction in patients with haemophilia

“…Macrovascular endothelial function was assessed by brachial artery flow‐mediated dilation (FMD), and microvascular endothelial function was assessed by hyperaemic velocity time integral (VTI). Details of the methodology have been described previously …”

“…Details of the methodology have been described previously. 12 Data analysis was performed using SPSS version 10. Mann-Whitney U test was used to assess the difference of continuous variables between patients with ED and without ED.…”

“…Studies have shown inconsistent results about the prevalence of HTN, diabetes and smoking in PWH, which are the established risk factors for ED in general population . Our recent published study on endothelial function in PWH reported reduced microvascular endothelial function (indicated by velocity time integral [VTI], during reactive hyperaemia) compared to the age and cardiovascular risk factor‐matched healthy controls . Since ED is a well‐recognized early manifestation of endothelial dysfunction, we investigated the prevalence of ED in our PWH cohort using the validated International Index of Erectile Function (IIEF) questionnaire .…”

“…[VTI], during reactive hyperaemia) compared to the age and cardiovascular risk factor-matched healthy controls. 12 Since ED is a well-recognized early manifestation of endothelial dysfunction, we investigated the prevalence of ED in our PWH cohort using the validated International Index of Erectile Function (IIEF) questionnaire. 1 Besides assessing if endothelial function is related to erectile dysfunction in PWH, this study also examined potential known risk factors for ED in PWH, including co-infections, painful joints and medication use.…”