Adult medulloblastoma: a case report

Mduma, Emmanuel; Awuor, Adagi; Lugina, Emmanuel

doi:10.1186/s13256-022-03531-3

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Medulloblastoma is a cancerous brain tumor that normally appears in young children and during adulthood prior to the age of 40 [171,172]. MB mainly refers to a malignant pediatric tumor that develops in the cerebellum, a specific region in the back of the Information obtained from [13,107,156,160,[164][165][166][167][168][169][170].…”

Section: Medulloblastomamentioning

confidence: 99%

The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

2023

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Statins are common drugs that are clinically used to reduce elevated plasma cholesterol levels. Based on their solubility, statins are considered to be either hydrophilic or lipophilic. Amongst them, simvastatin has the highest lipophilicity to facilitate its ability to cross the blood-brain barrier. Recent studies have suggested that simvastatin could be a promising therapeutic option for different brain complications and diseases ranging from brain tumors (i.e., medulloblastoma and glioblastoma) to neurological disorders (i.e., Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease). Specific mechanisms of disease amelioration, however, are still unclear. Independent studies suggest that simvastatin may reduce the risk of developing certain neurodegenerative disorders. Meanwhile, other studies point towards inducing cell death in brain tumor cell lines. In this review, we outline the potential therapeutic effects of simvastatin on brain complications and review the clinically relevant molecular mechanisms in different cases.

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Section: Medulloblastomamentioning

confidence: 99%

The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

2023

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Metastatic brainstem medulloblastoma: a clinical case report

Novikov,

Yasinskaya

et al. 2024

Bulletin of Neurology, Psychiatry and Neurosurgery

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Medulloblastoma (MB) is one of the most common tumors of the central nervous system (CNS) of embryonic origin. MB is a malignancy that is quite common in pediatric patients; it represents a small proportion of brain tumors in young people, with an incidence of 0.6 per million per year. The peak age of diagnosis among the pediatric population is 3-6 years, while patients between 15 and 44 years old account for only 25%. The purpose of the study: to demonstrate a clinical case of surgical treatment of a patient with CNS metastasis of brainstem medulloblastoma. Methods. The article presents our clinical case of surgical treatment of a patient with medulloblastoma metastasis to the right temporal lobe. Results. Medulloblastoma is a heterogeneous brain tumor that is very rare in adults, especially those over 40 years of age, and accounts for less than 1% of all primary brain tumors in adults. Medulloblastoma metastases are most often found in the spinal cord and its membranes, less often in the cerebral hemispheres and ventricular system, which is associated with cerebrospinal fluid pathways. In foreign and Russian literature, there are relatively few publications on studies of metastatic lesions of medulloblastoma in adults; these studies are either considered as separate clinical observations or in conjunction with the development of medulloblastoma metastases in children. Non-specific neurological symptoms of medulloblastoma in adults can lead to later instrumental studies and specific therapy, and can also act as an unfavorable prognostic factor for the disease. Conclusion. Early detection and neurosurgical intervention are the key to preventing mortality and improving patient outcomes. Currently, only a few cases of medulloblastoma in adults are known; to prevent patient mortality, more detailed genetic and molecular studies of MB, including cerebrospinal fluid, risk stratification, description of oncological treatment, and monitoring of results to analyze MB sensitivity to chemotherapy and EBRT, as well as maintaining a registry of patients over 18 years old with brain medulloblastoma and dynamic observation of their family members in connection with oncological vigilance are needed.

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Adult medulloblastoma: a case report

Cited by 2 publications

References 19 publications

The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

Metastatic brainstem medulloblastoma: a clinical case report

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