Adult medulloblastoma: Clinical profile and treatment results of 18 patients

Menon, Girish; Krishnakumar, K.; Nair, Suresh

doi:10.1016/j.jocn.2007.06.007

Cited by 47 publications

(36 citation statements)

References 19 publications

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“…In the study by Padovani et al which had the greatest number of patients, metastasis, postoperative performance, central nervous system involvement were determined as factors that are important for prognosis; [19] other prognostic factors were determined to be M stage and duration before initiation of postoperative RT in the study by Abacıoğlu et al [21] location of tumor in the study by Menon et al [30] type of surgery, RT and histology in the study by Lai et al [31] gender in the study by Riffaud et al [32] performed with gamma knife. There were less side effects, and higher doses could be attained by this way.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Surgery and Craniospinal Radiotherapy for Adult Patients with Medulloblastoma

Güzelöz¹

2017

TJ Oncol

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OBJECTIVEThe aim of the present study was to evaluate treatment outcomes for adult patients with medulloblastoma who received craniospinal irradiation following surgery at Dokuz Eylül University Radiation Oncology Department. METHODSTwelve patients were evaluated retrospectively. Median age was 31 years (range: 18-55 years). According to Chang staging system, 3 (25%) of the patients were T1, 2 (17%) were T2, 5 (42%) were T3, and 1 (8%) was T4; 1 patient could not be staged due to inadequate preoperative imaging. Tumor location, stage, presence of residual disease, duration between surgery and radiotherapy (RT), age, and sex were evaluated as prognostic factors. Statistical analyses were conducted using Kaplan-Meier method and SPSS for Windows, Version 15.0 (SPSS Inc., Chicago, IL, USA). RESULTSMedian dose was 36 Gy (range: 32-44 Gy) to craniospinal field and 54 Gy (range: 50-56 Gy) to primary tumor location. Median follow-up time was 62 months (range: 4-212 months). Five-, 10-, and 15-year overall survival rates were 79%, 63%, and 63%, and 5-, 10-and 15-year progression-free survival rates were 63%, 63%, and 63%, respectively. No statistically significant prognostic factor was found for survival rate. Three (25%) patients developed serious hematological toxicity during RT course. No grade 3 or 4 late side effect was observed. CONCLUSIONDespite the limited number of cases, results are consistent with the literature. Evaluation of features of this rare disease requires studies with larger number of.

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Section: Discussionmentioning

confidence: 99%

Outcomes of Surgery and Craniospinal Radiotherapy for Adult Patients with Medulloblastoma

Güzelöz¹

2017

TJ Oncol

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“…We use three markers, cyclin D1, p53 and β-catenin, to define different groups of adult MB, a neoplasm with difficult prognostic and therapeutic stratification 13,15,16 . β-catenin expression can be used as a therapeutic marker, with the advent of Wnt inhibitors.…”

Section: A B C D E F G Hmentioning

confidence: 99%

“…Extension studies must be performed in the management of this high-grade CNS tumour due to its tendency to disseminate to cerebrospinal fluid (CSF) and different meningeal locations. After surgical resection, radiotherapy should also be used to diminish the probability of dissemination 14,15 . Extracranial metastases to bones, lymph nodes, lungs, and liver can be observed in up to 5% of cases of MB, more than any other CNS tumour 2,15 .…”

Section: A B C D E F G Hmentioning

confidence: 99%

“…After surgical resection, radiotherapy should also be used to diminish the probability of dissemination 14,15 . Extracranial metastases to bones, lymph nodes, lungs, and liver can be observed in up to 5% of cases of MB, more than any other CNS tumour 2,15 . Some authors recommend locoregional radiotherapy at doses of 54 Gy or higher on the posterior fossa to achieve better local control and an extra 35Gy dose to eliminate malignant cells in the CSF 16 .…”

Section: A B C D E F G Hmentioning

confidence: 99%

“…Some authors recommend locoregional radiotherapy at doses of 54 Gy or higher on the posterior fossa to achieve better local control and an extra 35Gy dose to eliminate malignant cells in the CSF 16 . Paediatric studies have proven that the addition of chemotherapy (vincristine, CCNU, cisplatin and intrathecal methotrexate) may also improve outcome, resulting in increased usage in adult cases of MB 2,15 . In conclusion, medulloblastomas are the most commonly observed primitive tumours of the CNS and are almost always found in children.…”

Section: A B C D E F G Hmentioning

confidence: 99%

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Neuroradiology and Histopathology in Two Cases of Adult Medulloblastoma

et al. 2014

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Diagnosis of Neoplastic and Paraneoplastic Cerebellar Ataxia

Demarquay

Honnorat

2021

Handbook of the Cerebellum and Cerebellar Disorders

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Acquired cerebellar ataxia encompasses various diseases. Neoplastic causes have specific characteristics. First, because of the limited space in the posterior fossa, these tumors are considered as critical brain lesions. Clinically, patients with cerebellar tumors frequently present with signs of intracranial pressure, such as headache, vomiting, or decreased level of consciousness. Second, the incidence and the type of cerebellar tumors vary considerably with age. Pilocytic astrocytomas and medulloblastoma are common cerebellar neoplasms in children. Conversely, the most frequent cerebellar tumors in adults are metastases. However, in a context of a systemic cancer and in absence of brain metastase, paraneoplastic cerebellar ataxia (PCA) must be considered. In the past 20 years, several antibodies directed against neuronal and tumoral antigens have been described in association with PCA, leading to the description of different subtypes of PCA based on the associated antibodies, the clinical evolution, and the type of associated tumor. The purpose of this chapter is to present the main etiologies of neoplastic and paraneoplastic causes of acute cerebellar ataxia in children and adults.

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Adult medulloblastoma: Clinical profile and treatment results of 18 patients

Cited by 47 publications

References 19 publications

Outcomes of Surgery and Craniospinal Radiotherapy for Adult Patients with Medulloblastoma

Outcomes of Surgery and Craniospinal Radiotherapy for Adult Patients with Medulloblastoma

Neuroradiology and Histopathology in Two Cases of Adult Medulloblastoma

Diagnosis of Neoplastic and Paraneoplastic Cerebellar Ataxia

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