2017
DOI: 10.1534/genetics.116.193813
|View full text |Cite
|
Sign up to set email alerts
|

Adult Muscle Formation Requires Drosophila Moleskin for Proliferation of Wing Disc-Associated Muscle Precursors

Abstract: Adult muscle precursor (AMP) cells located in the notum of the larval wing disc undergo rapid amplification and eventual fusion to generate the Drosophila melanogaster indirect flight muscles (IFMs). Here we find that loss of Moleskin (Msk) function in these wing disc-associated myoblasts reduces the overall AMP pool size, resulting in the absence of IFM formation. This myoblast loss is due to a decrease in the AMP proliferative capacity and is independent of cell death. In contrast, disruption of Msk during p… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
9
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 8 publications
(9 citation statements)
references
References 61 publications
0
9
0
Order By: Relevance
“…Wing disc cell density was quantified by counting the total number of nuclei stained with DAPI in five random regions (430 μm 2 area each) of the wing imaginal disc. This was done for five different wing discs ( 68 ).…”
Section: Methodsmentioning
confidence: 99%
“…Wing disc cell density was quantified by counting the total number of nuclei stained with DAPI in five random regions (430 μm 2 area each) of the wing imaginal disc. This was done for five different wing discs ( 68 ).…”
Section: Methodsmentioning
confidence: 99%
“…In the abdominal segments, they proliferate while remaining associated with their muscle fibers similar to vertebrate satellite cells [ 207 , 208 ]. During the third larval instar, due to the activation of Wg signaling from the imaginal discs, AMPs undergo asymmetric divisions forming one stem cell and one Numb positive post-mitotic myoblast where Notch signaling is inhibited [ 209 , 210 ]. Thus, a large pool of myoblasts is primed for metamorphosis.…”
Section: Muscle Diversification—on the Road To Muscle Homeostasismentioning
confidence: 99%
“…To ablate myoblasts, we ectopically expressed moleskin (msk) RNAi. Msk is a nuclear importer of the FGF transcriptional activator ERK (Vishal et al, 2017). mskRNAi expression in the myoblasts reduced the number of myoblasts (Fig.…”
Section: Hh Gradients Form Independently In the Wing Disc Asp And Mmentioning
confidence: 94%