Adult nephroblastoma

Abstract

Clinical, pathologic, and ultrastructural features of two cases of adult nephroblastoma (Wilms' tumor) are presented, one in a 77-year-old man who had a large tumor with extracapsular extension and blood vessel invasion. Histologically, it consisted mainly of blastema. The patient died during the first course of postoperative chemotherapy with dactinomycin. The second patient was a 47-year-old woman with a tumor limited to the renal parenchyma. Histologically, the tumor was mainly epithelial. This tumor was discovered incidentally and remained unchanged for 5 years before surgery. The patient underwent nephrectomy and refused further treatment. She was free of disease 2 years after surgery.

Adult Wilms’ tumor: A case report and review of literature

“…However the incidence of persistent blastema in the adults is unknown [3]. Huser et al reported no persistent blastema in a study of 11 adult cases, while he mentioned that it could be found in 50% of children cases.…”

“…The true occurrence of adult Wilms' tumor is uncertain, because of the confusion in terminology [3]. In 1980 Kilton et al described strict criteria for the diagnosis.…”

Multimodal therapy for adult Wilms’ tumour: an experience from one centre

“…In the past, AWT was believed to be a fatal disease with survival rates less than 30% [3,[12][13][14]. Compared to adult patients, more than 85% of children with WT survived four years after their diagnosis [15,16].…”

Adult Wilms' tumor: clinical characteristics of four cases and review of the literature

“…The number of patients in the present study was not large enough to allow us to draw conclusions about the optimal treatment for adults with WT. However, the present study and previous results 4, 6,15 suggest that conventional chemotherapy regimens based on NWTS protocols used to treat children require modification in adult WT patients with advanced stage tumors and/or with UFH of tumor to improve the clinical outcome.…”