Adult neurogenesis with 5-HT expression in lesioned goldfish spinal cord

Takeda, Akihito; Nakano, Masato; Goris, Richard C.; Funakoshi, Kengo

doi:10.1016/j.neuroscience.2007.10.059

Cited by 43 publications

(39 citation statements)

References 54 publications

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“…Importantly, this also demonstrated a 3.5-fold increase in the number of spinalderived 5-HT þ varicosity profiles after regeneration (1 wpl vs. 1 week after re-lesion: P < 0.036). Increased innervation by spinal 5-HT þ neurons is probably a consequence of lesion-induced generation of 5-HT þ neurons, as observed in goldfish (Takeda et al, 2008). higher than in unlesioned animals (P < 0.001).…”

Section: Lesion-induced Quantitative Changes In 5-ht Terminals In Thementioning

confidence: 69%

“…This could be due to limited trophic support of these cells or to feedback from a rearranged spinal circuitry. Although in the closely related goldfish, a constant increase in the number 5-HT neurons after a spinal lesion was also noted, no reduction was seen at later stages (Takeda et al, 2008). It is possible that this phenomenon only occurs after the last time point analyzed in goldfish.…”

Section: Zebrafish Spinal Cord Regenerationmentioning

confidence: 93%

“…Also, in the spinal cord of the sea lamprey, regeneration of serotonergic descending axons has been reported (Cornide-Petronio et al, 2011). In addition, there is lesion-induced generation of serotonergic cells in the spinal cord of the closely related goldfish (Takeda et al, 2008). However, quantitative analyses of terminal densities necessary for a comparison of the potential functionality of the regenerated with the unlesioned situation are missing.…”

mentioning

confidence: 99%

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Plasticity of tyrosine hydroxylase and serotonergic systems in the regenerating spinal cord of adult zebrafish

Kuscha

Barreiro‐Iglesias

Becker

et al. 2012

J of Comparative Neurology

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Monoaminergic innervation of the spinal cord has important modulatory functions for locomotion. Here we performed a quantitative study to determine the plastic changes of tyrosine hydroxylase-positive (TH1(+); mainly dopaminergic), and serotonergic (5-HT(+)) terminals and cells during successful spinal cord regeneration in adult zebrafish. TH1(+) innervation in the spinal cord is derived from the brain. After spinal cord transection, TH1(+) immunoreactivity is completely lost from the caudal spinal cord. Terminal varicosities increase in density rostral to the lesion site compared with unlesioned controls and are re-established in the caudal spinal cord at 6 weeks post lesion. Interestingly, axons mostly fail to re-innervate more caudal levels of the spinal cord even after prolonged survival times. However, densities of terminal varicosities correlate with recovery of swimming behavior, which is completely lost again after re-lesion of the spinal cord. Similar observations were made for terminals derived from descending 5-HT(+) axons from the brain. In addition, spinal 5-HT(+) neurons were newly generated after a lesion and transiently increased in number up to fivefold, which depended in part on hedgehog signaling. Overall, TH1(+) and 5-HT(+) innervation is massively altered in the successfully regenerated spinal cord of adult zebrafish. Despite these changes in TH and 5-HT systems, a remarkable recovery of swimming capability is achieved, suggesting significant plasticity of the adult spinal network during regeneration.

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Section: Lesion-induced Quantitative Changes In 5-ht Terminals In Thementioning

confidence: 69%

Section: Zebrafish Spinal Cord Regenerationmentioning

confidence: 93%

mentioning

confidence: 99%

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Plasticity of tyrosine hydroxylase and serotonergic systems in the regenerating spinal cord of adult zebrafish

Kuscha

Barreiro‐Iglesias

Becker

et al. 2012

J of Comparative Neurology

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“…Adult neurogenesis in fishes is closely related to the ability to regenerate neural tissue after injury [4,5]. However, it remains unknown how the process of reparative neurogenesis correlates with cell proliferation and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of Cell Migration and Apoptosis in Cerebellum of Juvenile Masu Salmon Oncorhynchus Masou After Injury

Stukaneva¹

2015

AJBIO

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Apoptosis in various cerebellar zones of juvenile masu salmon Oncorhynchus masou after mechanical injury was investigated by TUNEL-labeling. In the brain of 4 month-old juveniles of O. masou growth in different parts of cerebellum and proliferative activity in secondary matrix zones of cerebellum were continued. TUNEL-labeling was observed in the injured cerebellum 2 days after damage. The induction of proliferative activity in different matrix zones: granular eminences, dorsal part of molecular layer and surface layers of corpus cerebellum were noted. The proliferative activity in regional neurogenic niches is increased after injury of cerebellum. The maximal number of apoptotic elements in the cerebellum was observed in zones of the radial cell migration. We suggest that in damaged cerebellum both adult born cells and cells formed as a result of the reparative neurogenesis can be eliminated during radial migration as result of natural morphogenetic processes. Patterns of tangential and radial migration of cells were observed near the area of injury. The highest rate of apoptosis index was detected in the dorsal matrix zone corresponding to the zone of secondary neurogenesis. This testifies to the elimination of the newly formed cells at the stage of their localization in the matrix zones. The intensity of the apoptotic response varies in different areas of O. masou cerebellum.

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“…The spontaneous regeneration of neuronal cells from stem cell progenitors after SCI has been reported in adult fish [e.g. serotonergic interneurons in goldfish (Takeda et al, 2008) and motor neurons in zebrafish (Reimer et al, 2008)], which is in marked contrast to the absence of neuronal replacement observed in mammals (Meletis et al, 2008). Reimer et al showed that regeneration of motor neurons occurs following SCI in adult zebrafish, and that the new motor neurons are integrated into the spinal cord circuits.…”

mentioning

confidence: 99%

Targeting ependymal stem cells in vivo as a non-invasive therapy for spinal cord injury

Barreiro‐Iglesias

2010

Disease Models &Amp; Mechanisms

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Adult neurogenesis with 5-HT expression in lesioned goldfish spinal cord

Cited by 43 publications

References 54 publications

Plasticity of tyrosine hydroxylase and serotonergic systems in the regenerating spinal cord of adult zebrafish

Plasticity of tyrosine hydroxylase and serotonergic systems in the regenerating spinal cord of adult zebrafish

Monitoring of Cell Migration and Apoptosis in Cerebellum of Juvenile Masu Salmon Oncorhynchus Masou After Injury

Targeting ependymal stem cells in vivo as a non-invasive therapy for spinal cord injury

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