Adult onset asthma in non‐allergic women working in dampness damaged buildings: A retrospective cohort study

Graff, Pål; Bryngelsson, Ing‐Liss; Fredrikson, Mats; Flodin, Ulf

doi:10.1002/ajim.22952

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…This may explain the different OR values observed for men and women in this work because there appear to be gender-based differences in immune responses 33–35. These differences are not well understood but similar effects have been seen for asthma 36 37…”

Section: Discussionmentioning

confidence: 70%

Risks of developing ulcerative colitis and Crohn’s disease in relation to silica dust exposure in Sweden: a case–control study

et al. 2020

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ObjectiveTo determine whether occupational exposure to silica dust causes an increased risk of developing Crohn’s disease (CD) and ulcerative colitis (UC).DesignCase–control study of CD (K50) and UC (K51) from 2007 through 2016. Controls were matched to cases (2:1) based on age, sex and county at the time of diagnosis. A job exposure matrix was used to estimate the occupational silica exposure of all cases and controls.SettingMedical and occupational data from the National Outpatient Register were used to implement a case–control analysis, while the two controls used for each case were selected from the National Register of the Total Population.ParticipantsAll men and women aged 20–65 years old who were diagnosed with CD (K50) and UC (K51) during the years of study were included and assigned two controls, resulting in 58 136 cases and 116 272 controls.Main outcomesSilica dust exposure correlates with an increased risk of developing UC in men and CD in women.ResultsThe prevalence of UC was significantly higher in the group exposed to silica dust (OR 1.13, 95% CI 1.06 to 1.21) than in controls, particularly in individuals with over 5 years exposure. When stratified by sex, a significantly increased OR was detected for men (OR 1.33, 95% CI 1.05 to 1.22). This trend was also consistent with longer exposure times. The prevalence of UC was not increased in exposed women. The prevalence of CD was significantly increased among exposed women (OR 1.29, 95% CI 1.01 to 1.65), but not for exposed men.ConclusionsSilica dust exposure correlates with an increased risk of developing UC, especially in men, and the risk seems to increase with the duration and degree of exposure. Conversely, silica dust exposure correlates positively with the risk of developing CD in women.

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Section: Discussionmentioning

confidence: 70%

Risks of developing ulcerative colitis and Crohn’s disease in relation to silica dust exposure in Sweden: a case–control study

et al. 2020

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“…For exposure to cleaning agents, 7 studies were included for new‐onset asthma 54–59 and 8 for the impact on asthma‐related outcomes 31,60–66 (Tables 2.3 and 2.4). For damp/mould exposure, 26 studies were included for new‐onset asthma 67–92 and 22 studies for the impact on asthma‐related outcomes 93–114 (Tables 2.5 and 2.6). For pesticide exposure, 8 studies were included for new‐onset asthma 115–122 and 2 studies for the impact on asthma‐related outcomes 123,124 (Tables 2.7 and 2.8).…”

Section: Resultsmentioning

confidence: 99%

The impact of indoor pollution on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma

Agache,

Canelo‐Aybar,

Annesi‐Maesano

et al. 2024

Allergy

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Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new‐onset asthma (incidence) and (ii) adverse asthma‐related outcomes (impact). MEDLINE, EMBASE and Web of Science were searched for indoor pollutant exposure studies reporting on new‐onset asthma and critical and important asthma‐related outcomes. Ninety four studies were included: 11 for VOCs (7 for incidenceand 4 for impact), 25 for cleaning agents (7 for incidenceand 8 for impact), 48 for damp/mould (26 for incidence and 22 for impact) and 10 for pesticides (8 for incidence and 2 for impact). Exposure to damp/mould increases the risk of new‐onset wheeze (moderate certainty evidence). Exposure to cleaning agents may be associated with a higher risk of new‐onset asthma and with asthma severity (low level of certainty). Exposure to pesticides and VOCs may increase the risk of new‐onset asthma (very low certainty evidence). The impact on asthma‐related outcomes of all major indoor pollutants is uncertain. As the level of certainty is low or very low for most of the available evidence on the impact of indoor pollutants on asthma‐related outcomes more rigorous research in the field is warranted.

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“…Epidemiological studies have previously observed that indoor MD exposure is associated with respiratory health effects such as upper respiratory tract symptoms, the development of asthma and asthma deterioration [ 1 , 2 , 3 ]. So far, these studies have mainly focused on children’s risk of asthma, other respiratory tract symptoms, and MD exposure at home or in schools [ 4 , 5 , 6 , 7 , 8 ], but some previous research has also established a temporal relationship between workplace MD exposure, asthma [ 9 , 10 , 11 , 12 ] and rhinitis symptoms [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Findings among Patients with Respiratory Symptoms Related to Moisture Damage Exposure at the Workplace—The SAMDAW Study

et al. 2021

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Background: Respiratory tract symptoms are associated with workplace moisture damage (MD). The focus of this observational clinical study was patients with workplace MD-associated symptoms, to evaluate the usefulness of different clinical tests in diagnostics in secondary healthcare with a special interest in improving the differential diagnostics between asthma and laryngeal dysfunction. Methods: In patients referred because of workplace MD-associated respiratory tract symptoms, we sought to systematically assess a wide variety of clinical findings. Results: New-onset asthma was diagnosed in 30% of the study patients. Laryngeal dysfunction was found in 28% and organic laryngeal changes in 22% of the patients, and these were common among patients both with and without asthma. Most of the patients (85%) reported a runny or stuffy nose, and 11% of them had chronic rhinosinusitis. Atopy was equally as common as in the general population. Conclusions: As laryngeal changes were rather common, we recommend proper differential diagnostics with lung function testing and investigations of the larynx and its functioning, when necessary, in cases of prolonged workplace MD-associated symptoms. Chronic rhinosinusitis among these patients was not uncommon. Based on this study, allergy testing should not play a major role in the examination of these patients.

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Adult onset asthma in non‐allergic women working in dampness damaged buildings: A retrospective cohort study

Cited by 5 publications

References 19 publications

Risks of developing ulcerative colitis and Crohn’s disease in relation to silica dust exposure in Sweden: a case–control study

Risks of developing ulcerative colitis and Crohn’s disease in relation to silica dust exposure in Sweden: a case–control study

The impact of indoor pollution on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma

Clinical Findings among Patients with Respiratory Symptoms Related to Moisture Damage Exposure at the Workplace—The SAMDAW Study

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