Adult Ontogeny of Rat Working Memory of Social Interactions

Taylor, George T.; Farr, Susan A.; Griffin, Mike; Humphrey, William; Weiß, Jürgen

doi:10.1093/gerona/54.3.m145

Cited by 15 publications

(8 citation statements)

References 38 publications

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“…A similar agedependent deterioration of social memory was reported in rats (34,35). We observed again a significant impairment in the social memory task in mature Cnr1 Ϫ/Ϫ mice.…”

Section: Discussionsupporting

confidence: 90%

Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors

Bilkei-Gorzó

Rácz

Valverde

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

138

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The molecular mechanisms contributing to the normal age-related decline of cognitive functions or to pathological learning and memory impairment are largely unknown. We demonstrate here that young mice (6 -7 weeks) with a genetic deletion of the cannabinoid CB1 receptor performed as well as WT mice, or often better, in a number of learning and memory paradigms, including animal models of skill-learning, partner recognition, and operant conditioning. In contrast, the performance of mature mice (3-5 months) lacking CB1 receptors was much worse than that of age-matched WT animals. In most tests, these mice performed at the same level as old animals (14 -17 months), suggesting that the decline in cognitive functions is accelerated in the absence of CB1 receptors. This rapid decline in CB1-deficient animals is accompanied by a loss of neurons in the CA1 and CA3 regions of the hippocampus.aging ͉ gene knockout ͉ learning ͉ hippocampus ͉ memory

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“…A similar agedependent deterioration of social memory was reported in rats (34,35). We observed again a significant impairment in the social memory task in mature Cnr1 Ϫ/Ϫ mice.…”

Section: Discussionsupporting

confidence: 90%

Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors

Bilkei-Gorzó

Rácz

Valverde

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

138

View full text Add to dashboard Cite

show abstract

“…Puzzlingly, another study found that habituation to a familiar juvenile is greater in seven and eleven month old male Wistar rats compared to three month old adults [22]. The only study apart from the present to use Long-Evans hooded rats found, as we have, that social memory was largely preserved during aging in male rats of this strain (although it was more susceptible to the disruptive effects of interference) [32].…”

Section: Methodscontrasting

confidence: 52%

Social recognition memory: Influence of age, sex, and ovarian hormonal status

Markham

Juraska

2007

Physiology & Behavior

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Social recognition memory underlies many forms of rodent interaction and can be easily tested in the laboratory. Sex differences in aspects of this memory have been reported among young adults, and some studies indicate an age-related decline among male rats. In contrast, neither the impact of natural fluctuations in ovarian hormones nor the performance of aged female rats on social recognition memory has been previously evaluated. In experiments 1 and 2, the social recognition memory of young adult female Long-Evans rats (age 3-5 mos.) was compared during proestrus and estrus, and performance was found to be stable across estrous cycle phases. In experiment 3, the social recognition memory of young adults as compared to aged (16.5-19.5 mos.) rats was tested using the social discrimination procedure, following delays of 15, 45, 90 or 120 minutes. The estropausal status of aged female rats was tracked during the experiment but was not found to influence memory ability. Males of both ages investigated juveniles (both novel and familiar) more than did females, although despite this difference, both sexes demonstrated robust memory. Interestingly, only young adult females were capable of demonstrating memory following the longest delay. Collectively, our findings indicate that the pattern of age-related changes in social recognition memory is subtle and that aging does not greatly alter the behavioral sex differences observed among young adults.

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“…These olfactory cues are used to provide critical information about the environment, individual recognition, and an individual's health (Morrison and Ludvigson, 1970). Because rats reportedly solve olfactory problems more rapidly than visual ones and use olfaction as a primary mode of communication (Slotnick and Katz, 1974), olfaction is a valuable tool to study learning and memory in rodents (Eichenbaum, 1998;Taylor et al, 1999). In the social food preference task, a rat alters its choice of food after an encounter with a conspecific that has recently eaten a particular food.…”

Section: Olfactory Social Learning and Memorymentioning

confidence: 99%