Adult T-cell leukemia: clinical and hematologic features of 16 cases

Uchiyama, Takashi; Yodoi, Junji; Sagawa, Kimitaka; Takatsuki, Kiyoshi; Uchino, Haruto

doi:10.1182/blood.v50.3.481.bloodjournal503481

Cited by 1,071 publications

(492 citation statements)

References 20 publications

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“…As the authors noted, the clinical presentation is comparable to that of HTLV1-associated adult T-cell leukaemia/lymphoma (ATLL), which may present with leukaemia, with lymphadenopathy, or involvement of other sites such as skin. 3,4 In the recently proposed World Health Organization (WHO) classification of haematopoietic and lymphoid neoplasms, 5,6 two principle neoplasias derived from mature NK-cells are recognized. The first is extranodal NK/T cell lymphoma, nasal type (extranodal NK/T lymphoma), which was included in the REAL classification as angiocentric lymphoma.…”

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confidence: 99%

Aggressive NK cell lymphomas: insights into the spectrum of NK cell derived malignancies

Quintanilla-Martı́nez

Jaffe

2000

Histopathology

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confidence: 99%

Aggressive NK cell lymphomas: insights into the spectrum of NK cell derived malignancies

Quintanilla-Martı́nez

Jaffe

2000

Histopathology

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“…Response to therapy is poor when compared (35,36), which also include the Sezary cell disease (1, 2, 37). In Japanese adult T cell leukaemia (38) the immunological pattern is T 3 + , T4+, T8-, and serum from these patients possesses antibodies to adult human T cell leukaemia-lymphoma virus (or ATLV) (29).…”

Section: Discussionmentioning

confidence: 99%

Chronic T cell lymphocytosis with large granular lymphocytes of helper (OKT4) phennoype

Berrébi

Talmor

Vorst

et al. 1985

Scandinavian Journal of Haematology

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A 54‐year‐old asymptomatic male patient was followed for more than 7 y and presented a constant T cell lymphocytosis without skin involvement or bone marrow depression. No clinical or haematological aggravation was noted during this follow‐up. Morphologically, the cells were large granular lymphocytes strongly positive for beta‐D‐glucuronidase, negative for acid phosphatase and with features of T cells on transmission and scanning electron microscopy. The immunological studies of the lymphocytes showed the following parameters: E rosettes+, mouse rosettes‐, SmIg‐, OKT3+, OKT4 +, OKT8‐, OKT6‐, Ia‐, TdT‐, NK‐, HTLV‐, decreased PHA and PWM stimulation, no interleukin 2 production and failure to enhance Ig synthesis in a PWM driven system. The karyotype was normal. This case of chronic T cell lymphocytosis with large granular lymphocytes helper profile and defect of helper function, not reported in the literature, may correspond to a distinct entity in the heterogeneous group of chronic T cell disorders.

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“…It should be noted that heterogeneity exists among ATL with regard to the presence or absence of suppressor activity (Tatsumi et al, 1978) and life span (Uchiyama et al. 1977).…”

Section: Discussionmentioning

confidence: 99%

“…Adult T-cell leukemia (ATL), proposed by Takatsuki and his associates (Uchiyama et al, 1977), has characteristics of neoplastic cells originating in fairly well differentiated T-cells al., 1979). On mitogen stimulation.…”

Section: Introductionmentioning

confidence: 99%

Correlation of aberrant proliferation with T‐cell growth factor in adult T‐Cell leukemia cells

Tsuda

Takatsuki

1983

Hematological Oncology

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SUMMARYPeripheral blood lymphocytes from seven patients with adult T-cell leukemia (ATL) were found to lack PHA-responsiveness. However, in most of the cases, minute but distinct proliferation could be induced and maintained by human spleen cell conditioned medium containing PHA or by a combination of PHA and conditioned medium ofgibbon cell line, MLA-144 (MLA-144 CM). These results indicate that the lack of response to mitogens of ATL cells might be attributed not only to the failure ofthese cells to produce T-cell growth factor (TCGF) upon activation, but also to their poor responsiveness to TCGF. Furthermore, a direct proliferative response to mitogen-free MLA-144 CM was shown in two out of seven patients; these two patients experienced rapidly progressive clinical courses. This observation raises the possibility that TCGF promotes the growth of ATL cells in vivo, and is related to the clinical course of the disease.KEY WORDS Adult T-cell leukemia Mitogen T-cell growth factor lnterleukin 2

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Adult T-cell leukemia: clinical and hematologic features of 16 cases

Cited by 1,071 publications

References 20 publications

Aggressive NK cell lymphomas: insights into the spectrum of NK cell derived malignancies

Aggressive NK cell lymphomas: insights into the spectrum of NK cell derived malignancies

Chronic T cell lymphocytosis with large granular lymphocytes of helper (OKT4) phennoype

Correlation of aberrant proliferation with T‐cell growth factor in adult T‐Cell leukemia cells

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