2021
DOI: 10.1002/ijc.33901
|View full text |Cite|
|
Sign up to set email alerts
|

Adult T‐cell leukemia‐lymphoma acquires resistance to DNA demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism

Abstract: Adult T‐cell leukemia‐lymphoma (ATL) is an aggressive neoplasm derived from T‐cells transformed by human T‐cell lymphotropic virus‐1 (HTLV‐1). Recently, we reported that regional DNA hypermethylation in HTLV‐1‐infected T‐cells reflects the disease status of ATL and the anti‐ATL effects of DNA demethylating agents, including azacitidine (AZA), decitabine (DAC) and a new DAC prodrug, OR‐2100 (OR21), which we developed. Here, to better understand the mechanisms underlying drug resistance, we generated AZA‐, DAC‐ … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
8
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6

Relationship

2
4

Authors

Journals

citations
Cited by 10 publications
(12 citation statements)
references
References 46 publications
1
8
0
Order By: Relevance
“…AZA-resistant (AZA-R) cells were established previously by long-term exposure to the drug. 15 The parental cell lines, as well as the AZA-R subclones, were authenticated previously using short tandem repeat profiling. 15 Cells were cultured in RPMI-1640 (Sigma-Aldrich, St. Louis, MO) containing 10% fetal bovine serum.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…AZA-resistant (AZA-R) cells were established previously by long-term exposure to the drug. 15 The parental cell lines, as well as the AZA-R subclones, were authenticated previously using short tandem repeat profiling. 15 Cells were cultured in RPMI-1640 (Sigma-Aldrich, St. Louis, MO) containing 10% fetal bovine serum.…”
Section: Methodsmentioning
confidence: 99%
“… 15 The parental cell lines, as well as the AZA-R subclones, were authenticated previously using short tandem repeat profiling. 15 Cells were cultured in RPMI-1640 (Sigma-Aldrich, St. Louis, MO) containing 10% fetal bovine serum. All experiments were performed using mycoplasma-free cells.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…In [1], the following details were missing at the end of “Material and Methods” on page 1187 in the published version:…”
mentioning
confidence: 99%