Adult-type granulosa cell tumour of the testis: Report of a case and review of the literature

Abstract

Granulosa cell tumours (GCTs) can be either juvenile or adult type, and more commonly occur in the ovaries. Adult-type GCTs of the testis (AGCTT) are very rare and only 46 cases have previously been reported. We report here on a 48-year-old Filipino man with a left testicular AGCTT, which measured 1.2 × 1.2 × 1.0 cm. He underwent radical orchidectomy with postoperative surveillance for 1 year, which included computed tomography with oral intravenous contrast and clinical examinations, which have been unremarkable. The previously reported AGCTTs were briefly reviewed.

Adult Granulosa Cell Tumor of the Testis: A Case Report with a Review of the Literature

“…Our patient presented with unspecific scrotal symptoms that were not related to the tiny testicular tumor that was only detected with ultrasonography. Sonographic features were frequently reported and typically involve hypoechoic well circumscribed masses with positive color-coded sonographic signals [37, 49]. But anechoic areas corresponding to cystic parts of the tumor have also been observed [7, 52].…”

<p>Adult-type granulosa cell tumor of the testicle: case report</p>

“…As for any solid testicular mass, the standardized initial management is radical orchiectomy. Retroperitoneal lymph nodes dissection (RPLND) has been additionally performed in a minority of cases with lymph node metastasis in testicular GCT 2–4,6,14. Conversely, Mosharafa et al argue that “prophylactic” RPLND is only a triumphant option in early stages of the disease, but not in the higher stages when lymph nodes are already involved; on account of most patients studied died of metastatic disease despite the addition of chemotherapy and radiotherapy 13…”

“…The aGrCT presents clinically as a painless, slow-growing neoplasm over an inconstant period of time and averaging an imprecise 5.4-years of enlargement 4. Moreover, it has the potential to metastasize after the initial diagnosis is made 1,2. The prevalence age ranges from 16 to 77 years and is often above 50 years old 2–4.…”

“…Moreover, it has the potential to metastasize after the initial diagnosis is made 1,2. The prevalence age ranges from 16 to 77 years and is often above 50 years old 2–4. Gynecomastia in 25% of cases decreased libido and erectile dysfunction that may be associated with symptoms generated by hormonal abnormalities, such as estrogen hypersecretion 2–5…”

Adult-type granulosa cell tumor of the testis: A case report and review of the literature

“… 1 These neoplasms usually present with painless testicular swelling and rarely involve gynecomastia and sexual side effects such as decreased libido and erectile dysfunction. 3 Adult GCTs of the testicle occur at a mean age of 40 years old and have malignant potential whereas juvenile GCTs of the testicle are benign and occur in the first 6 months of life. 4 Although the majority of adult GCTs of the testicle are benign (∼84%), prophylactic orchiectomies are still used for treatment.…”