Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis

Vrieling, Alina; Buck, Katharina; Kaaks, Rudolf; Chang‐Claude, Jenny

doi:10.1007/s10549-010-1116-4

Cited by 145 publications

(109 citation statements)

References 33 publications

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“…28 The exposure of interest in our study was adult weight gain (i.e., generally a gain of body fat), which potentially represents an age-related metabolic change that may be important in the development of prostate cancer; however, BMI reflects both lean body mass and adipose mass. 29 Our findings that adult weight gain is positively associated with risks of highrisk and fatal prostate cancers correspond to the results of previous meta-analyses. However, we assessed the potential nonlinear relationship between adult weight gain and prostate cancer risk and found a positive association between low-tomoderate weight gain and risks of total and low-intermediaterisk prostate cancers, which were not in agreement with the null or inverse association between BMI and risks of total or localized prostate cancer in previous meta-analyses.…”

Section: Cancer Epidemiology 870supporting

confidence: 91%

Adult weight gain and risk of prostate cancer: A dose–response meta‐analysis of observational studies

Chen

Shi

et al. 2015

Intl Journal of Cancer

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The association between adult weight gain and risk of prostate cancer has not been widely studied and the findings are inconsistent. Therefore, our study aimed to investigate the association between adult weight gain and risk of prostate cancer. PubMed, Embase and Web of Science databases were searched for relevant studies published before September 2014 using terms related to weight gain and prostate cancer. Summary estimates were obtained using the random-effects model. Doseresponse meta-analysis, sensitivity analysis and publication bias tests were performed. Nine studies involving 497,634 participants and 22,338 cancer cases were included. For total prostate cancer, a positive relationship with adult weight gain was observed until weight gain increased to >30 kg. For low-intermediate-risk prostate cancer, a positive relationship with adult weight gain was observed until weight gain increased to >15 kg. For high-risk prostate cancer, we observed a positive linear relationship with adult weight gain with a relative risk (RR) of 1.02 [95% confidence interval (CI) 1.00-1.04] for every 5-kg increase. For fatal prostate cancer, we observed a positive linear relationship with adult weight gain with an RR of 1.12 (95% CI: 1.05-1.19) for every 5-kg increase. There is evidence that adult weight gain is associated with an increased risk of highrisk and fatal prostate cancer, but only low weight gain is positively associated with low-intermediate-risk prostate cancer.Prostate cancer is the most common cancer in men of the developed countries and the second most common cancer worldwide in 2008.1 The increase in prostate cancer incidence and mortality observed in immigrants from low-risk to highrisk countries suggests that lifestyle and dietary factors play an important role in the etiology of prostate cancer. 2,3 Excess body weight comprehensively reflects lifestyle and dietary factors, which occurs when the expenditure (i.e., physical activity) is less than the intake (i.e., high-fat diets). Excess body weight, as measured by body mass index (BMI), has been considered a factor for decreased and increased risk of localized and advanced prostate cancer, respectively.4 However, prostate cancer is a disease involving a long process of tumor initiation, promotion and progression; therefore, weight gain during adulthood might be related to subsequent prostate cancer risk. Adult weight gain is a dynamic measure that reflects fluctuations in weight over time, which is thought to be a better measure of adiposity than a static measure of weight such as BMI. 5The association between adult weight gain and prostate cancer risk has not been widely studied and the findings are inconsistent. Some studies showed positive association, 6,7 while other studies showed no associations. [8][9][10][11][12][13][14] A newly published meta-analysis reported that adult weight gain was unrelated to total prostate cancer.15 However, the finding that weight gain might be differentially associated with low-intermediate-and high-risk prostate cancer ha...

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Section: Cancer Epidemiology 870supporting

confidence: 91%

Adult weight gain and risk of prostate cancer: A dose–response meta‐analysis of observational studies

Chen

Shi

et al. 2015

Intl Journal of Cancer

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“…Also, in heavier women, plasma sex hormone binding globulin is decreased and, in turn, the amount of bioavailable oestrogen is increased (36,38). For weight gain, the increased risk for hormone receptor positive breast cancer in older postmenopausal women, similar to adult weight, is consistent with results from a metaanalysis (8).…”

Section: The Results Of a Pooled Analysis Of 7 Cohort Studies (9) Mosupporting

confidence: 72%

“…None of these studies investigated the association by tumor characteristics. Evidence from a limited number of studies suggest that adult weight gain is positively associated with postmenopausal breast cancer risk (1-3, 5-8), but few studies have investigated its association by age (2,3) or tumor hormone receptor status (4,8).…”

Section: Introductionmentioning

confidence: 99%

Associations between Weight in Early Adulthood, Change in Weight, and Breast Cancer Risk in Postmenopausal Women

Krishnan

Bassett

MacInnis

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Adult weight is positively associated with postmenopausal breast cancer but few studies have investigated whether there are associations with weight and body mass index (BMI) in early adulthood, or subsequent weight change.Methods: A total of 14,441 postmenopausal women from the Melbourne Collaborative Cohort Study (MCCS) were followed for 16.5 years (mean) and 668 incident breast cancers were identified. Hazard ratios (HRs) were estimated using Cox regression.Results: Weight and BMI at 18 to 21 years were not associated with risk of any type of breast cancer and there was no variation by age. Women with the greatest increase in weight and BMI had higher risk at older ages [HR per 5 kg/m 2 gain in BMI ¼ 1.24; 95% confidence interval (CI), 1.11-1.40], although the test for homogeneity by

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“…These findings are supported by the fact that the association between BMI and risk of postmenopausal breast cancer is stronger for estrogen receptor (ER)-positive than -negative tumors (Feigelson et al 2006;Vrieling et al 2010;Suzuki et al 2011).…”

Section: Introductionmentioning

confidence: 92%

Differential impact of body mass index and its change on the risk of breast cancer by molecular subtype: A case-control study in Japanese women

et al. 2012

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Body mass index (BMI) is an independent risk factor for luminal-type breast cancer in Western populations. However, it is unclear whether the impact of BMI differs according to breast cancer subtype in Japanese populations. We conducted a case-control study with 715 cases and 1430 age-and menopausal status-matched controls to evaluate the associations of BMI and its change (from age 20 years to the current age) with breast cancer risk. We applied conditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Tumor subtypes were divided into four subtypes, namely the luminal, luminal/HER2, HER2-rich, and triple-negative subtypes. Current BMI and BMI change were positively associated with postmenopausal breast cancer risk. On stratified analysis by tumor subtype, we observed associations between current BMI and BMI change and postmenopausal breast cancer risk for the luminal subtype, with OR for each 1 kg/m 2 increase in current BMI of 1.14 (95% CI: 1.07 -1.20) and the corresponding OR of BMI change of 1.16 (1.09 -1.23) (each P trend < 0.001). Additionally, we found the same tendency for the triple-negative subtype, with the OR for a 1 kg/m 2 increase in current BMI of 1.21 (1.05 -1.39) and that for BMI change of 1.18 (1.02 -1.36) (P trend was 0.008 and 0.024, respectively). In premenopausal women, a suggestive inverse association was observed between BMI change and breast cancer risk for the luminal subtype only, with OR of BMI change of 0.93 (0.87 -1.00, P trend = 0.054). No association was seen between BMI at age 20 years and risk of any tumor subtype. In conclusion, BMI and its change are associated with the risk of both luminal and triple-negative breast cancer among postmenopausal Japanese women. These findings suggest the etiological heterogeneity of breast cancer among tumor subtypes.

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Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis

Abstract: . Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis. Breast Cancer Research and Treatment, Springer Verlag, 2010, 123 (3)

Cited by 145 publications

References 33 publications

Adult weight gain and risk of prostate cancer: A dose–response meta‐analysis of observational studies

Adult weight gain and risk of prostate cancer: A dose–response meta‐analysis of observational studies

Associations between Weight in Early Adulthood, Change in Weight, and Breast Cancer Risk in Postmenopausal Women

Differential impact of body mass index and its change on the risk of breast cancer by molecular subtype: A case-control study in Japanese women

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