Adults with initial metabolic syndrome have altered muscle deoxygenation during incremental exercise

Machado, Alessandro da Costa; Barbosa, Thales C.; Sales, Allan Robson Kluser; Souza, M.N.; Nóbrega, Antônio Cláudio Lucas da; Silva, Bruno M.

doi:10.1002/oby.21744

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…Exercise is an alternative to increase energy expenditure with (or even without) restricted intake [ 219 , 220 ]. This approach is not always feasible, since obesity is syndromic with cardiovascular disease and problems of mobility [ 221 ] and, despite numerous claims on the contrary, exercise it not sufficient to revert the damages of an established MS [ 222 ], and may not improve the health status [ 223 ]. However, well dosed exercise may provide benefits to mild cases and young patients [ 224 ].…”

Section: Normalization and Regulation Under Excess (If Any)mentioning

confidence: 99%

Dietary Energy Partition: The Central Role of Glucose

Remesar

Alemany

2020

IJMS

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Humans have developed effective survival mechanisms under conditions of nutrient (and energy) scarcity. Nevertheless, today, most humans face a quite different situation: excess of nutrients, especially those high in amino-nitrogen and energy (largely fat). The lack of mechanisms to prevent energy overload and the effective persistence of the mechanisms hoarding key nutrients such as amino acids has resulted in deep disorders of substrate handling. There is too often a massive untreatable accumulation of body fat in the presence of severe metabolic disorders of energy utilization and disposal, which become chronic and go much beyond the most obvious problems: diabetes, circulatory, renal and nervous disorders included loosely within the metabolic syndrome. We lack basic knowledge on diet nutrient dynamics at the tissue-cell metabolism level, and this adds to widely used medical procedures lacking sufficient scientific support, with limited or nil success. In the present longitudinal analysis of the fate of dietary nutrients, we have focused on glucose as an example of a largely unknown entity. Even most studies on hyper-energetic diets or their later consequences tend to ignore the critical role of carbohydrate (and nitrogen disposal) as (probably) the two main factors affecting the substrate partition and metabolism.

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Section: Normalization and Regulation Under Excess (If Any)mentioning

confidence: 99%

Dietary Energy Partition: The Central Role of Glucose

Remesar

Alemany

2020

IJMS

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“…Gurd et al ( Gurd et al, 2008 ) also demonstrated slower VO 2 kinetics responses and greater deoxyhemoglobin profile in older adults compared with healthy young adults. Machado et al ( Machado et al, 2017 ) showed that males with metabolic syndrome (MetS) had altered muscle deoxygenation kinetics during incremental exercise. Participants with MetS and age-matched controls performed a progressive and incremental cardiopulmonary exercise test in a cycle ergometer.…”

Section: Integrative Cardiovascular Physiology–insights Into Weakness...mentioning

confidence: 99%

The role of the microcirculation and integrative cardiovascular physiology in the pathogenesis of ICU-acquired weakness

2023

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Skeletal muscle dysfunction after critical illness, defined as ICU-acquired weakness (ICU-AW), is a complex and multifactorial syndrome that contributes significantly to long-term morbidity and reduced quality of life for ICU survivors and caregivers. Historically, research in this field has focused on pathological changes within the muscle itself, without much consideration for their in vivo physiological environment. Skeletal muscle has the widest range of oxygen metabolism of any organ, and regulation of oxygen supply with tissue demand is a fundamental requirement for locomotion and muscle function. During exercise, this process is exquisitely controlled and coordinated by the cardiovascular, respiratory, and autonomic systems, and also within the skeletal muscle microcirculation and mitochondria as the terminal site of oxygen exchange and utilization. This review highlights the potential contribution of the microcirculation and integrative cardiovascular physiology to the pathogenesis of ICU-AW. An overview of skeletal muscle microvascular structure and function is provided, as well as our understanding of microvascular dysfunction during the acute phase of critical illness; whether microvascular dysfunction persists after ICU discharge is currently not known. Molecular mechanisms that regulate crosstalk between endothelial cells and myocytes are discussed, including the role of the microcirculation in skeletal muscle atrophy, oxidative stress, and satellite cell biology. The concept of integrated control of oxygen delivery and utilization during exercise is introduced, with evidence of physiological dysfunction throughout the oxygen delivery pathway - from mouth to mitochondria - causing reduced exercise capacity in patients with chronic disease (e.g., heart failure, COPD). We suggest that objective and perceived weakness after critical illness represents a physiological failure of oxygen supply-demand matching - both globally throughout the body and locally within skeletal muscle. Lastly, we highlight the value of standardized cardiopulmonary exercise testing protocols for evaluating fitness in ICU survivors, and the application of near-infrared spectroscopy for directly measuring skeletal muscle oxygenation, representing potential advancements in ICU-AW research and rehabilitation.

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“…Besides that, the quiescent MuSCs also have unique gene expression profiles compared to the activated MuSCs. Genes such as Calcitonin Receptor (CalcR), CD34, α 7 -Integrin, Sprouty 1, Syndecan-4, CXCR4, Integrinβ1 (ITGB1), M-Cadherin, N-Cadherin, Notch Receptor, Osmotically inducible lipoprotein β (OSMβ), and Teneurin transmembrane protein 4 (Tenm4/Odz4) are highly expressed in quiescent MuSCs (Fu et al 2015b , Fukada et al 2013 , Goel et al 2017 , Machado et al 2017a , Machado et al 2017b , van Velthoven et al 2017 , Yamaguchi et al 2012 ).…”

Section: Quiescent Muscsmentioning

confidence: 99%

Regulation of muscle stem cell fate

Zhuang

2022

Cell Regen

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Skeletal muscle plays a critical role in human health. Muscle stem cells (MuSCs) serve as the major cell type contributing to muscle regeneration by directly differentiating to mature muscle cells. MuSCs usually remain quiescent with occasionally self-renewal and are activated to enter cell cycle for proliferation followed by differentiation upon muscle injury or under pathological conditions. The quiescence maintenance, activation, proliferation, and differentiation of MuSCs are tightly regulated. The MuSC cell-intrinsic regulatory network and the microenvironments work coordinately to orchestrate the fate transition of MuSCs. The heterogeneity of MuSCs further complicates the regulation of MuSCs. This review briefly summarizes the current progress on the heterogeneity of MuSCs and the microenvironments, epigenetic, and transcription regulations of MuSCs.

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Adults with initial metabolic syndrome have altered muscle deoxygenation during incremental exercise

Cited by 5 publications

References 41 publications

Dietary Energy Partition: The Central Role of Glucose

Dietary Energy Partition: The Central Role of Glucose

The role of the microcirculation and integrative cardiovascular physiology in the pathogenesis of ICU-acquired weakness

Regulation of muscle stem cell fate

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