Advance in Human Epithelial-Derived Organoids Research

Li, Fengjiao; Zhang, Peng; Wu, Saizhi; Yuan, Long; Z, Liu

doi:10.1021/acs.molpharmaceut.1c00452

Cited by 6 publications

(3 citation statements)

References 180 publications

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“…Multi-omics-based approaches that aim at identifying oxidation-sensitive nodes that intersect these pathways in different cell populations disrupted in the fibrotic lung have great potential to shed further light on disease pathogenesis, and may yield therapeutic strategies not realized to date. With the availability of high resolution redox-mapping [ 83 ], single cell-based mass spectrometry [ 84 ], and organoid technology to expand diseased cell populations [ 85 , 86 ], these studies are now possible and will yield new insights into redox, metabolic, and cellular perturbations with unprecedented detail.…”

Section: Discussionmentioning

confidence: 99%

S-Glutathionylation-Controlled Apoptosis of Lung Epithelial Cells; Potential Implications for Lung Fibrosis

2022

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Glutathione (GSH), a major antioxidant in mammalian cells, regulates several vital cellular processes, such as nutrient metabolism, protein synthesis, and immune responses. In addition to its role in antioxidant defense, GSH controls biological processes through its conjugation to reactive protein cysteines in a post-translational modification known as protein S-glutathionylation (PSSG). PSSG has recently been implicated in the pathogenesis of multiple diseases including idiopathic pulmonary fibrosis (IPF). Hallmarks of IPF include repeated injury to the alveolar epithelium with aberrant tissue repair, epithelial cell apoptosis and fibroblast resistance to apoptosis, and the accumulation of extracellular matrix and distortion of normal lung architecture. Several studies have linked oxidative stress and PSSG to the development and progression of IPF. Additionally, it has been suggested that the loss of epithelial cell homeostasis and increased apoptosis, accompanied by the release of various metabolites, creates a vicious cycle that aggravates disease progression. In this short review, we highlight some recent studies that link PSSG to epithelial cell apoptosis and highlight the potential implication of metabolites secreted by apoptotic cells.

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Section: Discussionmentioning

confidence: 99%

S-Glutathionylation-Controlled Apoptosis of Lung Epithelial Cells; Potential Implications for Lung Fibrosis

2022

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“…Future research should employ new cellular models that best represent CF disease and that can best mimic a given patient response to different treatments. This includes two-dimensional primary cultures from CF patients’ nasal brushing and three-dimensional organoids from airway or intestinal cells. − Concerning the high costs and difficulties associated with drug development for this orphan disease, drug-repositioning technology may represent an auxiliary option to reduce both costs and likelihood of adverse effects. However, this field has to be considered complementary to up-to-date CF drug discovery pipelines.…”

Section: Future Prospects and Final Thoughtsmentioning

confidence: 99%

Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives

et al. 2022

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In cystic fibrosis (CF), the deletion of phenylalanine 508 (F508del) in the CF transmembrane conductance regulator (CFTR) leads to misfolding and premature degradation of the mutant protein. These defects can be targeted with pharmacological agents named potentiators and correctors. During the past years, several efforts have been devoted to develop and approve new effective molecules. However, their clinical use remains limited, as they fail to fully restore F508del-CFTR biological function. Indeed, the search for CFTR correctors with different and additive mechanisms has recently increased. Among them, drugs that modulate the CFTR proteostasis environment are particularly attractive to enhance therapy effectiveness further. This Perspective focuses on reviewing the recent progress in discovering CFTR proteostasis regulators, mainly describing the design, chemical structure, and structure–activity relationships. The opportunities, challenges, and future directions in this emerging and promising field of research are discussed, as well.

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“…Organoids are 3D cultures derived from tissues, typically originating from multifunctional stem cells, embryonic stem cells, or adult stem cells[ 6 ]. They can mimic the function, morphological structure, and biological activity of original tissues and organs, making them useful for disease research and drug screening[ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

Wang,

Liu,

2024

World J Gastrointest Oncol

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BACKGROUND Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical research. Despite over a decade of development and increasing research achievements in this field, a systematic and comprehensive analysis of the research hotspots and future trends is lacking. AIM To address this problem by employing bibliometric tools to explore the publication years, countries/regions, institutions, journals, authors, keywords, and references in this field. METHODS The literature was collected from Web of Science databases. CiteSpace-6.2R4, a widely used bibliometric analysis software package, was used for institutional analysis and reference burst analysis. VOSviewer 1.6.19 was used for journal co-citation analysis, author co-authorship and co-citation analysis. The ‘online platform for bibliometric analysis (https://bibliometric.com/app )’ was used to assess the total number of publications and the cooperation relationships between countries. Finally, we employed the bibliometric R software package (version R.4.3.1) in R-studio, for a comprehensive scientific analysis of the literature. RESULTS Our analysis included a total of 1466 publications, revealing a significant yearly increase in articles on the study of gastrointestinal tumor organoids. The United States (n = 393) and Helmholtz Association (n = 93) have emerged as the leading countries and institutions, respectively, in this field, with Hans Clevers and Toshiro Sato being the most contributing authors. The most influential journal in this field is Gastroenterology. The most impactful reference is "Long term expansion of epithelial organs from human colon, adenoma, adenocarcinoma, and Barrett's epithelium". Keywords analysis and citation burst analysis indicate that precision medicine, disease modeling, drug development and screening, and regenerative medicine are the most cutting-edge directions. These focal points were further detailed based on the literature. CONCLUSION This bibliometric study offers an objective and quantitative analysis of the research in this field, which can be considered as an important guide for next scientific research.

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Advance in Human Epithelial-Derived Organoids Research

Cited by 6 publications

References 180 publications

S-Glutathionylation-Controlled Apoptosis of Lung Epithelial Cells; Potential Implications for Lung Fibrosis

S-Glutathionylation-Controlled Apoptosis of Lung Epithelial Cells; Potential Implications for Lung Fibrosis

Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives

Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

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