Advance-Platelet Rich Fibrin and Hyaluronic Acid Combination Improves Interleukin-6 and Granulation Index in Diabetic Foot Ulcer Patients

Kartika, Ronald Winardi; Alwi, Idrus; Suyatna, Franciscus D.; Yunir, Em; Waspadji, Sarwono; Immanuel, Suzanna; Silalahi, Todung; Sungkar, Saleha; Rachmat, Jusuf; Bardosono, Saptawati; Reksodiputro, Mirta Hediyati

doi:10.18585/inabj.v13i2.1501

Cited by 6 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Which, apparently, is associated with the pleiotropy of IL-6 and with a wide spectrum of biological activity of the studied cytokine in immune regulation, hematopoiesis, and inflammation, as well as in metabolic, proliferative, and regenerative processes. (23,24) The results of our work show that in rats with arterial hypertension, IL-6 levels increased after fracture (group 2.2) compared to similar cytokine concentrations in SHR rats without surgery (group 2.1), and also significantly decreased in the serum of SHR animals with modeled fractures while taking enalapril (group 2.4) compared to levels IL-6 in SHR rats of group 2.3.…”

Section: Bioactive Molecules and Biochemical Parametersmentioning

confidence: 56%

The Enalapril Use in Arterial Hypertension Stimulates The Reparative Processes in Fractures of The Proximal Femur

et al. 2022

View full text Add to dashboard Cite

BACKGROUND: In patients with a fracture of the proximal femur and concomitant arterial hypertension, there is a disturbance of the reparative processes of bone tissue. This research aimed to study the regulation of the reparative processes of fractures of the proximal femur with intramedullary osteosynthesis during the correction of concomitant hypertension, which was examined based on some markers using the rat model.METHODS: The study involved healthy Wistar rats and spontaneously hypertensive rats (SHR). The subjects were then grouped into healthy rats without exposure (1.1) SHR without exposure (2.1), healthy rats with modeled fractures of the proximal femur (1.2), SHR with modeled fractures of the proximal femur (2.2), SHR underwent hypertension correction with enalapril in subgroups without fracture (2.3) and SHR underwent hypertension correction with enalapril in subgroups with fracture (2.4). The levels of interleukin (IL)-6, tumor necrosis factor alpha (TNF-a), IL-10, amino-terminal propeptide procollagen type III (PIIINP), glucose, uric acid, creatinine, urea, cholesterol, and albumin were determined in the blood serum of the animals. Femur preparations were examined after the removal of intramedullary fixation. RESULTS: Serum IL-6 level of animal in group 2.4 (2.297±0.361 pg/mL) were reduced compared to the corresponding indicators of rats in group 2.3 (4.054±0.491 pg/mL, p<0.05). Serum glucose and urea levels of animal in group 2.4 (3.951±0.156 mmol/L, 6.552±0.426 mmol/L, respectively) were significantly reduced in comparison with the group 2.3 (6.384±0.890 mmol/L, 10.369±0.888 mmol/L, respectively). The histological results indicated a positive effect of the drug enalapril on the healing of fractures of the proximal femur in animals with hypertension.CONCLUSION: Correction of arterial hypertension with enalapril in fractures of the proximal femur improves the reparative processes of bone tissue.KEYWORDS: injury healing, remodeling, concomitant diseases, angiotensin-converting enzyme inhibitors, cytokines, growth factor, collagen, biochemical parameters

show abstract

Section: Bioactive Molecules and Biochemical Parametersmentioning

confidence: 56%

The Enalapril Use in Arterial Hypertension Stimulates The Reparative Processes in Fractures of The Proximal Femur

et al. 2022

View full text Add to dashboard Cite

show abstract

“…PRF is a safe, appropriate, easy-to-use adjunctive treatment modality with substantial possibility for the management of chronic skin wounds like pressure, diabetic foot, or venous-leg ulcers without any adversative effects. [ 27 , 28 ] However, studies have suggested that the reduced or compromised wound healing capacity in uncontrolled diabetic patients may be due to a reduction in growth factors and prolonged inflammatory responses due to increased proinflammatory cytokines in T2DM patients. [ 22 , 29 , 30 ] Thus, a modification in the protocol (rpm and time) for obtaining PRF in diabetic patients may be investigated.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Association of Platelet-Rich Fibrin (PRF) and Hyperacute Serum (HAS) with Glycemic Control (HbA1c) in Chronic Periodontitis Patients: An Ex vivo Study

Bains,

Mahendra,

Mahendra

et al. 2023

Journal of Pharmacy and Bioallied Sciences

View full text Add to dashboard Cite

Aim: To evaluate correlation of PRF and HAS with glycemic control (HbA1c) and other systemic parameters amongst the chronic periodontitis patients. Materials and Methods: Twenty-seven non-smoker, non-tobacco users, non-alcoholic moderate chronic periodontitis volunteers (Stage II, Grade A or B), aging between 40 and 50 years of both genders with type 2 diabetes mellitus (T2DM, HbA1c >6.5%) or without T2DM (HbA1c <6.5%), were recruited. After recording vitals and demographic parameters, 20 ml of intravenous fasting blood was collected, of which 11 ml blood was used for investigating complete blood count, lipid profile, glycated hemoglobin (HbA1c), C-reactive protein, and fasting insulin level. As per the standard protocol, PRF and HAS was prepared from the 9-ml blood sample of the patients. PRF obtained was quantified using Wensar’s analytical balance with a readability of 0.0001 g. Prepared HAS from the fibrin clot was quantified using a micropipette and stored in 2 ml Eppendorf vials. Results: Mean values of PRF and HAS obtained in the study were 2.0089 ± 0.844 g (ranged between 0.0 g and 3.968 g) and 1.540 ± 0.552 ml (ranged between 0.00 and 3.500 ml), respectively. The amount of PRF and HAS obtained were significantly higher in non-diabetic patients (mean 2.3093 g and 1.743 ml, respectively) as compared to diabetic patients (mean 1.5762 g and 1.266 ml, respectively). Results suggested a significant correlation between HbA1c level and quantification of PRF (P=0.007) and HAS (P=0.037), whereas no correlation was observed between HbA1c levels and hematologic, lipid, and demographic parameters. Conclusion: Within the limitation of the present study, it can be concluded that a significant correlation exists between the HbA1c level and quantification of PRF and HAS.

show abstract

“…Kartika et al evaluated the effect of topical use of autologous platelet-rich fibrin (A-PRF) and HA in DFU wound healing. The study was an open label, randomized, controlled trial conducted from July 2019 to April 2020 [47]. A combination of A-PRF + HA was applied on the surface of wounds and covered with bandage during the treatment period of 7 days.…”

Section: Ha In the Management Of Hard-to-heal Woundsmentioning

confidence: 99%

Wide Use of Hyaluronic Acid in the Process of Wound Healing—A Rapid Review

Antoszewska,

Sokolewicz,

Barańska-Rybak

2024

Sci. Pharm.

View full text Add to dashboard Cite

Hyaluronic acid (HA), as one of the main components of the extracellular matrix (ECM), plays an important role in the process of wound-healing and tissue-repair processes due to its unique properties and different physiological functions. HA has an ability to maintain a moist environment that promotes healing, the stimulation of growth factors and cellular constituents, and the migration of various cells essential for healing. This paper offers a review of HA use in the process of wound healing, with emphasis on hard-to-heal wounds, and examines its various applications in ophthalmology and otorhinolaryngology. It proves HA to be a versatile agent which finds its use in various fields of medicine for its antioxidant, anti-inflammatory, antibacterial properties and accelerated wound healing.

show abstract

Advance-Platelet Rich Fibrin and Hyaluronic Acid Combination Improves Interleukin-6 and Granulation Index in Diabetic Foot Ulcer Patients

Cited by 6 publications

References 24 publications

The Enalapril Use in Arterial Hypertension Stimulates The Reparative Processes in Fractures of The Proximal Femur

The Enalapril Use in Arterial Hypertension Stimulates The Reparative Processes in Fractures of The Proximal Femur

Quantitative Association of Platelet-Rich Fibrin (PRF) and Hyperacute Serum (HAS) with Glycemic Control (HbA1c) in Chronic Periodontitis Patients: An Ex vivo Study

Wide Use of Hyaluronic Acid in the Process of Wound Healing—A Rapid Review

Contact Info

Product

Resources

About