Advanced Atrioventricular Block and Complete Left Bundle Branch Block in a Case of Takayasu&amp;rsquo;s Aortitis

Naitoh, Motoko; Chino, Masamichi; Sakai, Takashi; Saitoh, Shigeharu; Ohkura, Mikihiko; Nishikawa, K.

doi:10.1159/000174579

Cited by 9 publications

(1 citation statement)

References 4 publications

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“…Here for the first time, we describe an autopsied case of Takayasu's arteritis associ ated with complete atrioventricular (AV) block. Complete AV block is very rare in patients with Takayasu's arteritis [5][6][7][8][9] a life-threatening complication. In our case, fibrosis associated with chronic inflammatory changes was detected in the cardiac conduc tion system, particularly the AV node.…”

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Scar Formation in the Cardiac Conduction System of a Patient with Takayasu’s Arteritis

Yokoi

Akiyama²,

Nishiuchi³

et al. 1992

Cardiology

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An autopsied case of Takayasu’s arteritis associated with complete atrioventricular (AV) block is described for the first time. The findings of scar formation and diffuse infiltration of lymphocytes into the cardiac conduction system, particularly the AV node, were similar to those in patients with connective tissue diseases or congenital complete heart block. The degree of AV block progressed with aggravation of the disease. These findings suggest that complete AV block may have been induced by acquired autoimmunity involving the cardiac conduction system.

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mentioning

confidence: 99%

Scar Formation in the Cardiac Conduction System of a Patient with Takayasu’s Arteritis

Yokoi

Akiyama²,

Nishiuchi³

et al. 1992

Cardiology

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Comparative Efficacy and Safety of Micronized Fenofibrate and Simvastatin in Patients With Primary Type Ha or IIb Hyperlipidemia

Farnier¹

1994

Arch Intern Med

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Fenofibrate and simvastatin provide similar variations on total cholesterol and low-density lipoprotein cholesterol levels after a 3-month treatment period, with simvastatin having the capacity to decrease these measures further when administered after fenofibrate. However, fenofibrate exhibits a significant effect on other established risk factors, such as total triglyceride, fibrinogen, and Lp(a) lipoprotein levels, and accordingly has a broader spectrum of activity than simvastatin.

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Late aneurysm formation of Valsalva sinus after aortic valve replacement due to Takayasu’s arteritis

et al. 2014

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Takayasu's arteritis (TA) is an inflammatory disease of unknown etiology involving the aorta and its branches, and also causes aortic regurgitation (AR). One of the most serious but rare complications after aortic valve replacement (AVR) in TA is aneurysm formation of the sinus of Valsalva. A 64-year-old woman had undergone AVR with a prosthetic valve for AR due to TA 4 years earlier and had received an implanted permanent pacemaker for complete atrioventricular block (AVB) 2 years later. Aortography 4 years postoperatively demonstrated aneurysm formation (47 mm in diameter) at the sinus of Valsalva although preoperative aortography showed severe AR without dilatation of the sinus of Valsalva. We recommended reoperation for the aneurysm but the patient refused. The perioperative histopathological examination revealed extensive destruction of the medial elastic fibers. Both the fragility of the sinus of Valsalva and the residual inflammation could have caused the patient's aneurysm formation. Moreover, extension of TA into the ventricular septum or mechanical compression of the aneurysm against the conduction system might have caused her progressive AVB. Close and lifelong follow-up for patients with TA regarding development of aneurysm after surgical treatment is indispensable when fragility of the aortic root had been confirmed.

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Advanced Atrioventricular Block and Complete Left Bundle Branch Block in a Case of Takayasu’s Aortitis

Cited by 9 publications

References 4 publications

Scar Formation in the Cardiac Conduction System of a Patient with Takayasu’s Arteritis

Scar Formation in the Cardiac Conduction System of a Patient with Takayasu’s Arteritis

Comparative Efficacy and Safety of Micronized Fenofibrate and Simvastatin in Patients With Primary Type Ha or IIb Hyperlipidemia

Late aneurysm formation of Valsalva sinus after aortic valve replacement due to Takayasu’s arteritis

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Advanced Atrioventricular Block and Complete Left Bundle Branch Block in a Case of Takayasu&rsquo;s Aortitis

Cited by 9 publications

References 4 publications

Scar Formation in the Cardiac Conduction System of a Patient with Takayasu&rsquo;s Arteritis

Scar Formation in the Cardiac Conduction System of a Patient with Takayasu&rsquo;s Arteritis

Comparative Efficacy and Safety of Micronized Fenofibrate and Simvastatin in Patients With Primary Type Ha or IIb Hyperlipidemia

Late aneurysm formation of Valsalva sinus after aortic valve replacement due to Takayasu’s arteritis

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Resources

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Advanced Atrioventricular Block and Complete Left Bundle Branch Block in a Case of Takayasu’s Aortitis

Scar Formation in the Cardiac Conduction System of a Patient with Takayasu’s Arteritis

Scar Formation in the Cardiac Conduction System of a Patient with Takayasu’s Arteritis