Advanced biomedical applications of carbon nanotube

Raphey, V.R.; Henna, T.K.; Nivitha, K.P.; Mufeedha, P.; Sabu, Chinnu; Pramod, K.

doi:10.1016/j.msec.2019.03.043

Cited by 209 publications

(102 citation statements)

References 160 publications

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“…In this regard, Carbon Nanotubes (CNTs) reinforcement may play a vital role as they possess a low density (~1.2g/cm 3 ), a high tensile strength (~100 GPa), a high Young's modulus (~900 GPa) and a tensile ductility of ~20%. Moreover, CNTs already attract a lot of attention as promising materials in various fields such as sensors [12], energy applications [13], biomedical applications [14], polymer composites [15,16]. Successful attempt to exploit mechanical properties of CNT has been demonstrated enormously in the case of CNT reinforced polymer composites with improved tensile strength [17], flexural strength [18] and fatigue resistance [19,20].…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics simulation based investigation of possible enhancement in strength and ductility of nanocrystalline aluminum by CNT reinforcement

Pal

Babu

Gargeya

et al. 2020

Materials Chemistry and Physics

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Molecular dynamics (MD) based study of nanocrystalline (NC) Al and CNT (carbon nanotube) reinforced NC Al specimens having grain sizes ~9 nm have been carried out under tensile loading using hybrid potentials for different temperatures (10 K, 300 K and 681 K) at a particular strain rate of 10 10 s-1. Structural variation and defect evolution during the deformation have been investigated. An enhancement in both strength and ductility is observed in case of the CNT embedded NC Al specimens with respect to NC Al specimen and such improvement is significant in case of (30,30) CNT embedded NC Al specimen. It is also found that NC Al matrix is fractured first, then the CNT at lower test temperature, whereas at high temperature, the CNT fractures before the matrix.

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Section: Introductionmentioning

confidence: 99%

Molecular Dynamics simulation based investigation of possible enhancement in strength and ductility of nanocrystalline aluminum by CNT reinforcement

Pal

Babu

Gargeya

et al. 2020

Materials Chemistry and Physics

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“…CNTs are currently the most promising material for fiber‐based smart systems. The high mechanical strength and electrical conductivity of CNT yarns created much initial interest in using these materials for electronic applications . Recently, numerous studies have also demonstrated the multi‐functionality of CNT yarns as fiber‐shaped electrical sensors, actuators, supercapacitors, and energy harvesters ( Figure ).…”

Section: Properties Of Cnt Yarnsmentioning

confidence: 99%

Carbon Nanotube Yarn for Fiber‐Shaped Electrical Sensors, Actuators, and Energy Storage for Smart Systems

et al. 2019

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201902670. Smart systems are those that display autonomous or collaborative functionalities, and include the ability to sense multiple inputs, to respond with appropriate operations, and to control a given situation. In certain circumstances, it is also of great interest to retain flexible, stretchable, portable, wearable, and/or implantable attributes in smart electronic systems. Among the promising candidate smart materials, carbon nanotubes (CNTs) exhibit excellent electrical and mechanical properties, and structurally fabricated CNT-based fibers and yarns with coil and twist further introduce flexible and stretchable properties. A number of notable studies have demonstrated various functions of CNT yarns, including sensors, actuators, and energy storage. In particular, CNT yarns can operate as flexible electronic sensors and electrodes to monitor strain, temperature, ionic concentration, and the concentration of target biomolecules. Moreover, a twisted CNT yarn enables strong torsional actuation, and coiled CNT yarns generate large tensile strokes as an artificial muscle. Furthermore, the reversible actuation of CNT yarns can be used as an energy harvester and, when combined with a CNT supercapacitor, has promoted the next-generation of energy storage systems. Here, progressive advances of CNT yarns in electrical sensing, actuation, and energy storage are reported, and the future challenges in smart electronic systems considered.

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“…RMSD and RMSF analyses also confirmed the simulation stability. [30], [70]- [72]. It seems that the application of these nanostructures (especially P-CNTs) to carry PD drugs can be an attractive topic for future studies.…”

Section: 3α-synuclein Protein Particles Contact Areamentioning

confidence: 99%

“…However, despite their vast utilities, second-generation CNTs seemed to be technically flawed for some novel applications. Ultimately, the last-generation CNTs or -doped CNTs were developed as a certain proportion of carbon atoms were replaced by other elements like nitrogen, bromine, and phosphorous [30], [31].…”

Section: Introductionmentioning

confidence: 99%

Potential Treatment of Parkinson's Disease, Using Last-Generation Carbon Nanotubes: A Bimolecular In-Silico Study

Alimohammadi

Nikzad

Khedri

et al. 2020

Preprint

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Background: Parkinson's disease (PD) is one of the most common neurodegenerative disorders. One of the underlying mechanisms of the disease is the accumulation of α-synuclein protein aggregates, including amyloids and Lewy bodies in the brain, resulting in the death of dopaminergic cells in the substantia nigra. The current treatments for PD are mainly focused on replacing dopamine. However, if these medications are stopped, the severity of PD will increase. Moreover, the drugs used for the treatment of PD are associated with considerable side effects and dietary restrictions. Therefore, necessary studies to develop more effective medications for PD seem to be indispensable. To prevent the progression of PD, avoiding the development of α-synuclein amyloids could be proposed. Methods: In this study, the effects of three last-generation nanotube-based structures on α-synuclein amyloid formation were investigated for the first time employing Molecular Dynamics (MD) simulation tools. Molecular dynamics provide a deep insight into atomic interactions and can well study α-synuclein amyloid formation at the atomic and molecular scales.Results: The molecular study results indicated that all of the nanotubes studied in this work, had strong energy interactions with α-synuclein. Therefore, nanotubes using phosphorus, nitrogen and boron dopants, have great potential to prevent α-synuclein amyloid formation. Among these nanotubes, phosphorus-doped carbon nanotube (P-CNT) has the most substantial interactions with α-synuclein. The P-CNT caused more hydrogen bonds to be formed between water and α-synuclein molecules. This phenomenon leads to a decrease in the compactness, stability, and contact area of α-synuclein proteins, which results in considerable changes in the secondary structure of α-synuclein.Conclusions: Doping nanotubes especially P-CNT could be very effective for preventing the α-synuclein amyloid formation and hence, halting the progression of PD. This molecular study paves the way for the use of the Doping nanotubes in the treatment of PD. These structures are highly tunable and flexible. Therefore, the results of this work can be developed to computational, experimental and clinical levels.

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Advanced biomedical applications of carbon nanotube

Cited by 209 publications

References 160 publications

Molecular Dynamics simulation based investigation of possible enhancement in strength and ductility of nanocrystalline aluminum by CNT reinforcement

Molecular Dynamics simulation based investigation of possible enhancement in strength and ductility of nanocrystalline aluminum by CNT reinforcement

Carbon Nanotube Yarn for Fiber‐Shaped Electrical Sensors, Actuators, and Energy Storage for Smart Systems

Potential Treatment of Parkinson's Disease, Using Last-Generation Carbon Nanotubes: A Bimolecular In-Silico Study

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