Advanced Biventricular Heart Failure due to Left Ventricular Noncompaction Cardiomyopathy Leading to the Formation of a Gastric Bezoar: The Implications of Heart Failure on the Gastrointestinal Tract
Abstract:Congestive heart failure (CHF) is a chronic disease process affecting multiple organ systems and is associated with significant morbidity and mortality. We report a case of a 43-year-old male with a history of unspecified cardiomyopathy who presented to the hospital with abdominal pain, distention, and nausea for 4 months. He was diagnosed with left ventricular noncompaction and gastroparesis. While symptoms of dyspnea, orthopnea, or increasing peripheral edema are the first that come to mind when thinking of … Show more
“…Many HF patients present with GI symptoms, such as abdominal pain, distension, nausea, vomiting, and bloating. These symptoms, however, are often overlooked, and specific therapies are lacking 24–26 …”
Section: Discussionmentioning
confidence: 99%
“…These symptoms, however, are often overlooked, and specific therapies are lacking. [24][25][26] Our study aimed to measure and analyze SW in vivo and determine whether SW are affected by HF. This goal was accomplished by a wireless recording of electrical activity in the small intestine of anesthetized eTNAP and control mice, reconstructing the low-and high-frequency bands, and comparing the data between groups.…”
Background: Gastrointestinal (GI) symptoms in heart failure (HF) patients are associated with increased morbidity and mortality. We hypothesized that HF reduces bioelectrical activity underlying peristalsis. In this study, we aimed to establish a method to capture and analyze slow waves (SW) in the small intestine in mice with HF.
Methods: We established a model of HF secondary to coronary artery disease in mice overexpressing tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells. The myoelectric activity was recorded from the small intestine in live animals under anesthesia. The low-and high-frequency components of SW were isolated in MATLAB and compared between the control (n = 12) and eTNAP groups (n = 8). Ckit-positive interstitial cells of Cajal (ICC) and Pgp9.5-positive myenteric neurons were detected by immunofluorescence. Myenteric ganglia were assessed by hematoxylin and eosin (H&E) staining. Results: SW activity was successfully captured in vivo, with both high-and lowfrequency components. Low-frequency component of SW was not different between endothelial TNAP (eTNAP) and control mice (mean[95%
“…Many HF patients present with GI symptoms, such as abdominal pain, distension, nausea, vomiting, and bloating. These symptoms, however, are often overlooked, and specific therapies are lacking 24–26 …”
Section: Discussionmentioning
confidence: 99%
“…These symptoms, however, are often overlooked, and specific therapies are lacking. [24][25][26] Our study aimed to measure and analyze SW in vivo and determine whether SW are affected by HF. This goal was accomplished by a wireless recording of electrical activity in the small intestine of anesthetized eTNAP and control mice, reconstructing the low-and high-frequency bands, and comparing the data between groups.…”
Background: Gastrointestinal (GI) symptoms in heart failure (HF) patients are associated with increased morbidity and mortality. We hypothesized that HF reduces bioelectrical activity underlying peristalsis. In this study, we aimed to establish a method to capture and analyze slow waves (SW) in the small intestine in mice with HF.
Methods: We established a model of HF secondary to coronary artery disease in mice overexpressing tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells. The myoelectric activity was recorded from the small intestine in live animals under anesthesia. The low-and high-frequency components of SW were isolated in MATLAB and compared between the control (n = 12) and eTNAP groups (n = 8). Ckit-positive interstitial cells of Cajal (ICC) and Pgp9.5-positive myenteric neurons were detected by immunofluorescence. Myenteric ganglia were assessed by hematoxylin and eosin (H&E) staining. Results: SW activity was successfully captured in vivo, with both high-and lowfrequency components. Low-frequency component of SW was not different between endothelial TNAP (eTNAP) and control mice (mean[95%
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