Advanced breeding techniques

Pal, Aruna; Chakravarty, A. K.

doi:10.1016/b978-0-12-816406-8.00021-8

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References 33 publications

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“…Although molecular docking analysis is available for the identification of various drug molecules with avian influenza virus ( Amir et al, 2011 ; Liu et al, 2015 ; Khan et al, 2017 ; Pal and Chakravarty, 2019b ), this is the first report of molecular docking analysis with the immune response molecules responsible for antiviral immunity against avian influenza and is the basis for finding drug for a disease. A series of immune response molecules are responsible for providing antiviral immunity with their respective interaction in various pathways as we depicted through String and KEGG pathway analyses in our current study.…”

Section: Discussionmentioning

confidence: 99%

RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks

Pal

Baviskar

2021

Front. Mol. Biosci.

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Avian influenza is a disease with every possibility to evolve as a human-to-human pandemic arising out of frequent mutations and genetic reassortment or recombination of avian influenza (AI) virus. The greatest concern is that till date, no satisfactory medicine or vaccines are available, leading to massive culling of poultry birds, causing huge economic loss and ban on export of chicken products, which emphasizes the need to develop an alternative strategy for control of AI. In the current study, we attempt to explore the molecular mechanism of innate immune potential of ducks against avian influenza. In the present study, we have characterized immune response molecules such as duck TLR3, TLR7, and RIGI that are predicted to have potent antiviral activities against the identified strain of avian influenza through in silico studies (molecular docking) followed by experimental validation with differential mRNA expression analysis. Future exploitation may include immunomodulation with the recombinant protein, and transgenic or gene-edited chicken resistant to bird flu.

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