Advanced Case of Achalasia That Appeared on 68Ga–Prostate-Specific Membrane Antigen PET/CT

Abstract

We report a known case of severe achalasia that appeared on 68Ga–prostate-specific membrane antigen (PSMA) PET/CT. The patient was a known case of high-grade transitional cell carcinoma and suspicious diagnosis of prostate cancer referred for 68Ga-PSMA PET/CT. 68Ga-PSMA PET/CT showed linear increased activity in the esophageal wall as well as a distended esophagus.

Different Appearances of 3 Malignancies in 68Ga-PSMA-11 Versus 18F-FDG PET/CT

“…68 Ga-PSMA-11 PET/CT demonstrates no abnormal uptake in the esophagus. This finding is not surprising since no esophageal cancer cases diagnosed with 68 Ga-PSMA PET/CT were described in the literature, although there is a single case report describing the appearance of achalasia 1,2 …”

“…This finding is not surprising since no esophageal cancer cases diagnosed with 68 Ga-PSMA PET/CT were described in the literature, although there is a single case report describing the appearance of achalasia. 1,2 FIGURE 2. Coronal 68 Ga-PSMA-11 PET and fused images (lower row) show significant pathological uptake in the right liver lobe (arrow), whereas no abnormal uptake is present in the liver (arrow) in 18 F-FDG PET and fused images (upper row).…”

Unusual Achalasia Presentation Detected on 131I SPECT/CT in a Papillary Thyroid Carcinoma Patient

“…Although the incidental appearance of achalasia has been reported before using radioiodine imaging, 3,4 whole-body 131 I scan was carried out alone. Achalasia has also been found in 99m Tc-pertechnetate imaging and 68 Ga-PSMA PET/CT 5–7 . 131 I scan plays a crucial role in the management of patients with differentiated thyroid cancer for the evaluation of remnant thyroid tissue, residual/recurrent metastatic disease, posttherapy tracer distribution, and response assessment to high-dose 131 I therapy 8 .…”

Radiomics and Artificial Intelligence in Radiotheranostics: A Review of Applications for Radioligands Targeting Somatostatin Receptors and Prostate-Specific Membrane Antigens

“…PSMA is a type II, 750-amino acid transmembrane protein anchored in the cell me brane of prostate epithelial cells [11]. Radiopharmaceuticals targeting PSMA for diagn tic imaging purposes include [ 68 Ga]Ga-PSMA-11, [ 68 Ga]Ga-PSMA-617, [ 68 Ga]Ga-PSM I&T, [ 18 [12,13]. C rently, 68 Ga or 18 F labeled radioligand binding to PSMA are paramount players in P applications [14].…”

“…Although the epi miologic importance of NETs is not as high as that of prostate cancer, NETs consist of 0 of all malignancies, and the incidence rate has increased six-fold over the past deca PSMA is a type II, 750-amino acid transmembrane protein anchored in the cell membrane of prostate epithelial cells [11]. Radiopharmaceuticals targeting PSMA for diagnostic imaging purposes include [ 68 Ga]Ga-PSMA-11, [ 68 Ga]Ga-PSMA-617, [ 68 [12,13]. Currently, 68 Ga or 18 F labeled radioligand binding to PSMA are paramount players in PCa applications [14].…”