Advanced diagnostic imaging of sentinel lymph node in early stage breast cancer

Li, Ping; Sun, Desheng

doi:10.1002/jcu.23151

Cited by 7 publications

(4 citation statements)

References 51 publications

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“…Iš naviko limfa pirmiausia pasiekia sarginius limfmazgius, neretai jų yra daugiau negu vienas [3]. Jei sarginiai limfmazgiai sveiki, visų pažasties limfmazgių šalinti nereikia [4]. Taip išvengiama pooperacinės limfedemos (15-30 %), hematomų ir seromų (10-52 %), neuropatijos (78 %), skausmo, mažėja gydymo kaina ir trukmė [5,6].…”

Section: įVadasunclassified

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Detection of Sentinel Lymph Nodes During Breast Cancer Surgery: A Literature Overview

Šepetys

Gudavičienė

Jakutis

2023

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Introduction. Detecting metastases is an important part of successful breast cancer treatment. Usually, the tumor tissue first spreads to the sentinel lymph nodes. Removal of the latter during surgery and histological examination allows to assess the patient’s disease stage, prognosis and treatment. The literature provides more than one approach or a combination of them, allowing us to accurately identify the breast’s sentinel lymph nodes and avoid removing all axillary lymph nodes. Purpose. To review the methods of intraoperative detection of breast sentinel lymph nodes presented in the literature. Research material and methods. Publications were searched using the specialized information search system Google Scholar. Keywords used in the search: breast sentinel lymph nodes, intraoperative detection. After evaluating the exclusion criteria, the review was based on 25 scientific publications. Results. 4 individual measures and 2 combinations of them can be used to detect sentinel breast lymph nodes during surgery. The materials used can be injected in 6 different ways. Conclusions. The combination of technetium-99m radiocolloid and methylene blue can be evaluated as the best method for intraoperative detection of sentinel lymph nodes in breast cancer patients. On the other hand, due to radiation and operating costs, more attention is being paid to the use of indocyanine green, superparamagnetic iron oxide, methylene blue dye, and the detection of metastases without surgery. Superficial methods of injecting the substance should be combined with deep ones due to the possibility of detecting extra-axillary sentinel lymph nodes of the breast. Ultimately, all decisions must be made on a case-by-case basis.

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Section: įVadasunclassified

“…contrast-enhanced ultrasound). Vėliau tai patvirtinama ar paneigiama atliekant biopsiją [4]. Minėti metodai kol kas retai naudojami klinikinėje praktikoje [7].…”

Section: Diskusijaunclassified

Detection of Sentinel Lymph Nodes During Breast Cancer Surgery: A Literature Overview

Šepetys

Gudavičienė

Jakutis

2023

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“…Through SLN mapping, the lymph nodes around the tumor are accurately identified and removed, followed by a histological examination to confirm the presence of lymph node metastasis and make it possible to diagnose metastatic cancer. SLN imaging methods include nuclear medicine molecular imaging, optical imaging, and near-infrared fluorescence imaging [ 5 ]. Evans blue or methylene blue for optical imaging is relatively invasive because imaging is difficult and lymph nodes must be exposed during surgery to check the staining of the lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

“…Currently used nanoparticles for lymphadenography can detect lymph nodes, but cannot distinguish metastatic lymph nodes [ 5 , 8 , 9 ]. Lymph node dissection as a strategy for preventing cancer metastasis can cause side effects such as lymphedema and a reduction in the patient’s quality of life [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for Lymph Node-Directed Delivery

et al. 2023

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Lymph nodes are organs that control immune cells and provide a major pathway for primary tumors to metastasize. A nanoparticles-based strategy has several advantages that make it suitable for achieving effective lymphatic delivery. First, the size of nanoparticles can be tailored to meet a size range appropriate for lymphatic migration. In addition, functionalized nanoparticles can target cells of interest for delivery of drugs or imaging probes. Existing lymph node contrast agents map all lymph nodes regardless of metastasis status; however, by using nanoparticles, it is possible to selectively target lymphatic metastases. Moreover, using functionalized nanoparticles, it is possible to specifically deliver anticancer drugs to metastatic lymph nodes. In this review, we introduce the use of nanoparticles for lymphatic mapping, in particular highlighting design considerations for detecting metastatic lymph nodes. Furthermore, we assess trends in lymph node-targeting nanoparticles in clinical practice and suggest future directions for lymph node-targeting nanoparticles.

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