Advanced glycation end products and arterial stiffness in patients with diabetic nephropathy and patients with chronic kidney disease without diabetes

Stróżecki, Paweł; Kurowski, Robert; Flisiński, Mariusz; Stefańska, Anna; Odrowąż-Sypniewska, Grażyna; Manitius, Jacek

doi:10.20452/pamw.1974

Cited by 24 publications

(29 citation statements)

References 6 publications

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“…[36][37][38][39][40] Only comprehensive preventive strategies can lower an extremely high risk of increased morbidity and mortality in patients on renal replacement therapy. 25, 41,42 REfERENCEs…”

Section: 31mentioning

confidence: 99%

Location of nonmelanoma skin cancers in patients after kidney transplantation

Sułowicz¹,

Wojas‐Pelc²,

Ignacak³

et al. 2014

Polish Archives of Internal Medicine

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Section: 31mentioning

confidence: 99%

Location of nonmelanoma skin cancers in patients after kidney transplantation

Sułowicz¹,

Wojas‐Pelc²,

Ignacak³

et al. 2014

Polish Archives of Internal Medicine

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“…4 Maturity-onset diabetes of the young (MODY) is the most common type of monogenic diabetes. It constitutes a group of early-onset autosomal dominant forms of diabetes that together account for up to 2% of all HbA 1c was measured by high-performance liquid chromatography (Bio-Rad, Hercules, California, United States).…”

mentioning

confidence: 99%

Genetic testing for monogenic diabetes using targeted next-generation sequencing in patients with maturity-onset diabetes of the young

Szopa¹,

Ludwig-Gałęzowska²,

Radkowski³

et al. 2015

Polish Archives of Internal Medicine

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“…AGE are a key biochemical characteristic of diabetes [33]. In a concentration-dependent reaction, surplus sugar molecules bind to protein structures without the mediation of enzymes, causing conformational changes and protein function disruptions.…”

Section: Gm3 Interferes With Regenerative Capacity Of Renal Cellsmentioning

confidence: 99%

The Missing Link - Likely Pathogenetic Role of GM3 and Other Gangliosides in the Development of Diabetic Nephropathy

Vukovic

Božić

Markotić

et al. 2015

Kidney Blood Press Res

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Despite scientific advances, diabetic nephropathy remains both a therapeutical challenge, and one of the major diabetic complications. Chemical structure of gangliosides, the most complex of glycosphingolipids, is characterised by one or more sialic acids and carbohydrate groups linked to a ceramide structure. Their potential pathogenetic role in a number of disorders linked to diabetes mellitus has recently been conjectured, due to evidence of their negative modulation of the insulin-mediated signaling and general effects on key cell functions like proliferation, differentiation, apoptosis, cellular signaling and adhesion. Elevated levels of advanced glycation products (AGE) usually found in diabetic conditions seem to be responsible for increased concentration of a-series gangliosides in tissues, most notably GM3. GM3 was shown to compromise the renal pericyte and mesangial cell regeneration via the inactivation of VEGF receptor and the receptor-associated Akt signaling pathway. Likewise, the lipid raft theory opened a new research area for GM3 influence, since in the glycosynapse model glycosphingolipids have a key cell-to-cell communication unit with modulating capabilities on signaling receptors. The goal of this review is to provide insight into currently available theories on proposed mechanisms that mark the GM3 as a pathophysiological mediator in the development of diabetic nephropathy.

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Advanced glycation end products and arterial stiffness in patients with diabetic nephropathy and patients with chronic kidney disease without diabetes

Cited by 24 publications

References 6 publications

Location of nonmelanoma skin cancers in patients after kidney transplantation

Location of nonmelanoma skin cancers in patients after kidney transplantation

Genetic testing for monogenic diabetes using targeted next-generation sequencing in patients with maturity-onset diabetes of the young

The Missing Link - Likely Pathogenetic Role of GM3 and Other Gangliosides in the Development of Diabetic Nephropathy

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