2021
DOI: 10.1016/j.jchf.2021.05.009
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Advanced Heart Failure Epidemiology and Outcomes

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Cited by 83 publications
(66 citation statements)
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References 32 publications
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“…The gold standard ESC definition that we applied required manual review of electronic health record data by a clinician to identify patients with advanced HF. 7 , 8 Although we recently described advanced HF in a population-based community cohort, it is imperative to gain a more comprehensive understanding of patients with advanced HF and their outcomes across broader populations. Development of electronic algorithms can help facilitate that goal.…”
Section: Discussionmentioning
confidence: 99%
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“…The gold standard ESC definition that we applied required manual review of electronic health record data by a clinician to identify patients with advanced HF. 7 , 8 Although we recently described advanced HF in a population-based community cohort, it is imperative to gain a more comprehensive understanding of patients with advanced HF and their outcomes across broader populations. Development of electronic algorithms can help facilitate that goal.…”
Section: Discussionmentioning
confidence: 99%
“…In this cohort of patients with a diagnostic code for HF, the patients with advanced HF were known, as they had been previously identified by our group using a rigorous process that included manual review of electronic health record data. The process used to identify patients with advanced HF has been previously described 8 ; in brief, we applied the ESC’s advanced HF case definition. 7 The ESC case definition requires all of the following within a 12-month period: (1) hospitalizations or ED visits for HF/VA; (2) 1 or more echocardiographic signs of severe HF, including severely reduced EF, significantly reduced right ventricular function, severe inoperable valvular heart disease or congenital heart disease, or significant diastolic dysfunction; (3) severe exercise limitations; and (4) persistent New York Heart Association class III (advanced) or IV symptoms despite attempts to optimize medical, surgical, and device-based therapy.…”
Section: Methodsmentioning
confidence: 99%
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“…This alarming epidemic is anticipated to worsen as the global population continuously grows older, contributing to a sustained healthspan–lifespan gap, further compounded by a younger, increasingly more morbid population at risk of developing heart failure [ 4 , 5 , 6 ]. Chronic heart failure syndrome is malignant in its progressive non-reversible nature, and notoriously refractory to treatment options resulting in recurrent hospitalizations and poor survival causing death in two-thirds of patients within five years of diagnosis [ 7 ]. Pump failure is a common manifestation of florid disease shared across heart failure etiologies, provoked by complex underlying cardiomyopathic substrates [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, compounds such as spironolactone, sacubitril/valsartan, and sodium–glucose cotransporter 2 inhibitors (SGLT-2i) have proved to be effective over a wide range of LVEF [ 13 ]. Moreover, recent evidence suggests that acute HF and advanced HF may occur at any level of LVEF, and prognosis is unrelated to LVEF [ 14 ].…”
mentioning
confidence: 99%