Advanced malignant minor salivary glands tumors of the oral cavity

Mücke, Thomas; Robitzky, Luisa K.; Kesting, Marco; Wagenpfeil, Stefan; Holhweg-Majert, Bettina; Wolff, Klaus‐Dietrich; Hölzle, Frank

doi:10.1016/j.tripleo.2009.01.013

Cited by 32 publications

(17 citation statements)

References 39 publications

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“…[18–20] Recent and past studies are consistent in revealing a reduced survival in patients with positive lymph node at time of primary therapy, and the 5-year survival rate was significant different with or without cervical lymph node metastasis (44-48 % vs . 73-77 %).…”

Section: Elective Neck Dissectionmentioning

confidence: 79%

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Management of salivary gland carcinomas - a review

et al. 2016

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Salivary gland carcinomas are a heterogeneous group of tumors with many histological subtypes which occur in both major and minor salivary glands. However, they have a relatively low of incidence. Their rarity limits study size and the ability to perform phase III trials. Therefore, to date, the entire management is usually varied. Certain published studies have paid more attention to the systemic therapy in the management of metastatic or locally recurrent salivary gland cancer, while little effort has been made to study the entire management for this lesions. Although results of treatment for patients with salivary gland carcinoma have improved in recent years, the treatment of salivary gland cancers is still not standardized. And some patients who haven’t received optimal treatment strategies had a reduced survival. In this review, the topics covered include surgery and radiotherapy, selective neck dissection, chemotherapy, and targeted therapy, which aimed to summarize the optimal management approaches and to develop recommendations for managing this lesions. For these rare cancers, there is also a need for a determined, coordinated effort to conduct high-quality clinical trials.

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Section: Elective Neck Dissectionmentioning

confidence: 79%

“…[17] Other studies also indicated that surgical treatment significantly influenced OS for patients presenting with recurrent disease ( P < .0001). [18–20] In addition, primary RT is mainly reserved for patients with inoperable disease, those who refuse surgery or those who have an unresectable lesion.…”

Section: Surgery and Radiotherapymentioning

confidence: 99%

Management of salivary gland carcinomas - a review

et al. 2016

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“…This finding was similar to earlier studies, which have reported the palate as the most common site for minor salivary tumors, in which 42-75% of tumors occurred. 12,17,18 The second most common site of minor salivary gland tumors in this study was buccal mucosa. A study carried out by Li et al 3 also showed the buccal region as the second location for minor salivary gland tumors followed by the floor of the mouth and lips.…”

Section: Discussionmentioning

confidence: 76%

Epithelial salivary gland tumors in Ahvaz, southwest of Iran

Atarbashi-Moghadam

Moghadam

Dadfar³

2010

Dental Research

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“…Adenoid cystic carcinoma and mucoepidermoid carcinoma are the most frequent histological variants and the same was observed in the current study. [16171819] Distant relapse rate for malignant MSG reaching up to 30% has been demonstrated. [20] In the present study, only one patient developed distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Survival outcome of malignant minor salivary tumors in Pakistani population

Iqbal

Bhatti

Hussain

et al. 2014

South Asian J Cancer

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Objective:Malignant tumors of minor salivary glands (MSG) are rare. Survival outcome in Pakistani population with malignant MSG tumors remains to be defined. The objective of this study was to report the clinical presentation, treatment modalities, and survival outcome of radically treated malignant tumors of MSG in Pakistani population.Materials and Methods:Between April 2003 and March 2011, 45 patients with malignant tumors of MSG were treated at Shaukat Khanum Cancer Hospital and included in the study. Patient characteristics and treatment modalities were assessed and local, regional, and distant failures determined. Relapse-free (RFS) and overall survival (OS) was calculated using Kaplan-Meier curves, and log-rank test was used to determine significance.Results:Median age was 40 (17-83) years. Male to female ratio was 1.25:1. Most common site was hard palate in 31 (69%) patients. Adenoid cystic carcinoma (51%) was the most common histological diagnosis. Nine patients (20%) underwent surgery as the only treatment modality, six patients received (13%) radiotherapy alone, and 30 patients (67%) had surgery followed by adjuvant radiotherapy. Eight patients developed recurrence (four local, two regional, one locoregional, and one distant). The 5-year actuarial overall OS and RFS was 77 and 66%, respectively. Age, T-stage, and treatment modality were significant for RFS, whereas T-stage and treatment modality were significant factors for OS.Conclusion:Surgery as single modality or combined with radiation therapy resulted in acceptable survival in Pakistani population with malignant minor salivary tumors.

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Advanced malignant minor salivary glands tumors of the oral cavity

Cited by 32 publications

References 39 publications

Management of salivary gland carcinomas - a review

Management of salivary gland carcinomas - a review

Epithelial salivary gland tumors in Ahvaz, southwest of Iran

Survival outcome of malignant minor salivary tumors in Pakistani population

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