Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy

Kawamura, Shinobu; Nakamura, Takafumi; Oya, Takeshi; Ishizawa, Shin; Sakai, Yuta; Tanaka, Tomonori; Saïto, Shigeru; Fukuoka, Junya

doi:10.1111/j.1440-1827.2007.02083.x

Cited by 62 publications

(40 citation statements)

References 19 publications

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“…Formerly, Kawamura et al reported a patient with SFT, localized in pelvis, who had multiple lung metastases, who had significant response to pelvic radiotherapy with total 50 Gy dose [9]. On the contrary, Dietrich et al indicated accelerated progression at the lesion in the course of Axial CT scan of the chest showing shrinkage at the lesion 6 weeks later from 60 Gy/30fx RT radiotherapy in a patient with SFT, which localized at the thoracic wall [10].…”

Section: Discussionmentioning

confidence: 96%

Recurrent solitary fibrous tumor of the pleura: significant response to radiotherapy

et al. 2009

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Solitary fibrous tumor (SFT) of the pleura is an uncommon neoplasm with non-specific symptoms and non-pathognomonical radiological findings. Surgery allows establishment of a definitive diagnosis as well as a cure of the disease. The role of radiotherapy or chemotherapy in the management of the disease is unclear because of the rarity of the disease and the successful results of the surgical treatment. Long-term clinical follow-up may be useful for the patients with SFT because of the potential adverse biological behavior of this tumor, which may lead to repeated recurrences and/or malignant transformation. We reported a 66-year-old woman with recurrence of SFT in the right lung, which had significant response to external thoracic radiotherapy.

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Section: Discussionmentioning

confidence: 96%

Recurrent solitary fibrous tumor of the pleura: significant response to radiotherapy

et al. 2009

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“…Based on the pathological features and the clinical presentation, the diagnosis of hypervascular malignant SFT was made. Then, based on a few previous reports [5,6], we planned preoperative radiation therapy in an attempt to reduce the risk of bleeding during the operation. Adequate information concerning the risks and benefits of the different kinds of therapeutic modalities was given, and the patient chose the performance of preoperative radiation therapy.…”

Section: Case Reportmentioning

confidence: 99%

“…Studies of pleural SFT were prolific in the 1980s, and the largest study indicated that SFT occurred almost equally in both sexes (195 female, 165 male) and that it occurred in all age groups (range 5-87 years, average 51 years) [5,8]. The reported tumor size ranged from 1-33 cm (average 11 cm), and the malignant potential was reported to be 12 % [5]. On the other hand, various extrapleural SFTs have been reported since the 1990s.…”

Section: Case Reportmentioning

confidence: 99%

“…On the other hand, various extrapleural SFTs have been reported since the 1990s. In 2007, Kawamura et al [5] analyzed 17 cases of SFT arising in the pelvic cavity from 10 studies. Pelvic SFT occurred in both sexes (7 female, 10 male) and in a patient age range from 23 to 73 years (average 50 years).…”

Section: Case Reportmentioning

confidence: 99%

“…Some reports in the literature have demonstrated the effectiveness of radiotherapy for the control of SFT. Pelvic radiotherapy (total dose 50 Gy) effectively controlled a pelvic SFT with multiple lung metastases [5], and external thoracic radiotherapy (total dose 60 Gy) reduced a recurrent SFT of the right lung [15]. Also, preoperative radiotherapy (total dose 40 Gy) significantly reduced an intracranial SFT [6].…”

Section: Case Reportmentioning

confidence: 99%

See 2 more Smart Citations

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

Nishikawa

Takei²,

Teshima³

et al. 2012

Int Canc Conf J

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Solitary fibrous tumor (SFT) is an uncommon neoplasm located in the pelvis. Here, we report a case of hypervascular malignant SFT in the mesentery of the rectum that showed a significant response to preoperative radiotherapy. A 36-year-old man presented to our department with constipation and dysuria. Abdominal computed tomography confirmed a large round neoformation (155 mm in the longest diameter) with an evident contrastenhanced periphery and a central necrotic area in the pelvis. Considering the results of the examinations, a pelvic neoplasm was strongly suspected. Due to the difficulty of safe gross total removal, a diagnostic laparotomy was indicated. Histologically, hypercellularity with spindleshaped cells and high mitotic activity was observed. Immunohistochemically, the tumor was positive for CD34, CD99, and bcl-2. The diagnosis of hypervascular malignant SFT was made. After the appropriate information had been given, the patient chose the use of preoperative radiotherapy. After local irradiation, the tumor size regressed to 105 mm in the longest diameter. Laparotomy revealed a tumor originating from the mesentery of the rectum, and the tumor was successfully excised. This case strongly suggested the potential applicability of preoperative radiotherapy for the safe gross total removal of a large pelvic SFT.

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Malignant solitary fibrous tumor of the thyroid gland: Report of a case and review of the literature

Ning

Song

Xiang

et al. 2010

Diagnostic Cytopathology

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Solitary fibrous tumors of the thyroid gland (T-SFT) are rarely described, with only 21 cases being reported in the English literatures, all showing benign clinical characteristics. We herein present a 76-year-old woman presenting with a 3-month history of rapidly enlarging neck masses and the CT showed masses with partial calcification in the right thyroid lobe. We performed right hemithyroidectomy and isthmectomy with negative margin under general anesthesia. Histologically, the masses consisted of pleomorphic spindle cells with high mitoses and collagen bands. Immunohistochemically, the tumor cells showed positive reactions for CD34, vimentin and bcl-2, then a diagnosis of malignant solitary fibrous tumor of the right thyroid was made. Six months postoperatively, the CT showed the recurrence of the thyroid tumor and the presence of many nodules of varying sizes throughout bilateral pulmonary lobes. To our knowledge, this is the first case of malignant solitary fibrous tumor of the thyroid gland (T-SFT) with local recurrence and pulmonary metastasis and T-SFT must be considered in the differential diagnosis of spindle cells lesions in the thyroid gland. Correct diagnosis of the malignant T-SFT plays an important role in choosing appropriate therapeutic strategies and long-term follow-up is also extremely essential for these patients.

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Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy

Cited by 62 publications

References 19 publications

Recurrent solitary fibrous tumor of the pleura: significant response to radiotherapy

Recurrent solitary fibrous tumor of the pleura: significant response to radiotherapy

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

Malignant solitary fibrous tumor of the thyroid gland: Report of a case and review of the literature

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