Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond

Jalal, Salma; Dastidar, Sumitava; Tedesco, Francesco Saverio

doi:10.1016/j.ceb.2021.06.004

Cited by 38 publications

(40 citation statements)

References 110 publications

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“…In conclusion, our perspective work is in line with the recent advances in regenerative and precision medicine and the need of understanding the fundamental mechanisms in presomite and somite SC models and their role in microphysiological systems for skeletal muscle studies ( Jalal et al, 2021 ). Moreover, our ability to collect and manage postmortem presomite as well as somite hMPCs can significantly contribute to creating a new biobank shareable with researchers involved in physiological and pathological studies on skeletal muscle.…”

Section: Discussionsupporting

confidence: 64%

New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin

et al. 2022

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Human postmortem skeletal muscles are a unique source of satellite cells for skeletal muscle regenerative studies. Presomite and somite satellite cells obtained by postmortem muscles have been established as populations of human skeletal muscle precursor cells able to proliferate and differentiate in vitro. It is extremely interesting to have access to a large amount of postmortem human skeletal muscle precursor cells, especially from craniofacial as well as limb skeletal muscles in order to evaluate their potential application not only for the fundamental understanding of muscle physiology and diseases but also for drug testing in a challenging 3D-shaping muscles like skeletal muscle microphysiological systems.

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Section: Discussionsupporting

confidence: 64%

New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin

et al. 2022

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“…Skeletal muscle is a highly hierarchical tissue that is crucial for the human body. Recently, newly-developed 3D platforms exhibit much potential for skeletal muscle tissue generation [ 106 ]. An interlaced vascular network is crucial for the passive diffusion of nutrients and oxygen in muscle organoids.…”

Section: Discussionmentioning

confidence: 99%

Advances of Engineered Hydrogel Organoids within the Stem Cell Field: A Systematic Review

Yue

Liu

et al. 2022

Gels

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Organoids are novel in vitro cell culture models that enable stem cells (including pluripotent stem cells and adult stem cells) to grow and undergo self-organization within a three-dimensional microenvironment during the process of differentiation into target tissues. Such miniature structures not only recapitulate the histological and genetic characteristics of organs in vivo, but also form tissues with the capacity for self-renewal and further differentiation. Recent advances in biomaterial technology, particularly hydrogels, have provided opportunities to improve organoid cultures; by closely integrating the mechanical and chemical properties of the extracellular matrix microenvironment, with novel synthetic materials and stem cell biology. This systematic review critically examines recent advances in various strategies and techniques utilized for stem-cell-derived organoid culture, with particular emphasis on the application potential of hydrogel technology in organoid culture. We hope this will give a better understanding of organoid cultures for modelling diseases and tissue engineering applications.

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“…In the past several years, researchers have established various culture conditions based on a detailed understanding of myogenic development and have found appropriate combinations of essential factors to differentiate myogenic cells from PSCs. In-depth reviews have been published by Jalal et al [ 13 ] and Iberite et al [ 24 ]. Chiefly, there are two strategies for inducing differentiation from human PSCs.…”

Section: Pluripotent Stem Cell-derived Human Skeletal Muscle Tissuementioning

confidence: 99%

Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research

Kim

Son

2022

Endocrinol Metab

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Skeletal muscle is now regarded as an endocrine organ based on its secretion of myokines and exerkines, which, in response to metabolic stimuli, regulate the crosstalk between the skeletal muscle and other metabolic organs in terms of systemic energy homeostasis. This conceptual basis of skeletal muscle as a metabolically active organ has provided insights into the potential role of physical inactivity and conditions altering muscle quality and quantity in the development of multiple metabolic disorders, including insulin resistance, obesity, and diabetes. Therefore, it is important to understand human muscle physiology more deeply in relation to the pathophysiology of metabolic diseases. Since monolayer cell lines or animal models used in conventional research differ from the pathophysiological features of the human body, there is increasing need for more physiologically relevant <i>in vitro</i> models of human skeletal muscle. Here, we introduce recent studies on <i>in vitro</i> models of human skeletal muscle generated from adult myogenic progenitors or pluripotent stem cells and summarize recent progress in the development of three-dimensional (3D) bioartificial muscle, which mimics the physiological complexity of native skeletal muscle tissue in terms of maturation and functionality. We then discuss the future of skeletal muscle 3D-organoid culture technology in the field of metabolic research for studying pathological mechanisms and developing personalized therapeutic strategies.

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Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond

Cited by 38 publications

References 110 publications

New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin

New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin

Advances of Engineered Hydrogel Organoids within the Stem Cell Field: A Systematic Review

Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research

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