Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

Çakır, Tansel; Goktas, Bulent; Mutlu, Mehmet Fırat; Mutlu, İlknur; Bi̇lgi̇han, Ayşe; Erdem, Mehmet; Erdem, Ahmet

doi:10.5603/gp.2016.0001

Cited by 24 publications

(15 citation statements)

References 37 publications

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“…The most commonly used method to monitor oxidative stress is the measurement of parameters of antioxidant abilities and oxidative damage in the serum, since it is the least invasive and easily available method. It was found that the serum concentrations of oxidative damage markers (e.g., TBARS, AOPP, PCG) were higher, and the serum indices of antioxidant abilities parameters (e.g., GSH) were lower in postmenopausal women than in premenopausal women [33,34,35]. In addition, the glucose and lipid metabolism disorders are observed in postmenopausal women [35,36].…”

Section: Discussionmentioning

confidence: 99%

Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats

et al. 2019

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Rosmarinic acid is found in medicinal and spice plants such as rosemary, lemon balm, and mint. The aim of the study was to investigate the effect of rosmarinic acid on parameters of glucose and lipid metabolism and parameters of oxidative stress in rats in the early phase of estrogen deficiency. The study was carried out on mature female Wistar rats divided into the following groups: sham-operated control rats, ovariectomized control rats, and ovariectomized rats treated orally with rosmarinic acid at a dose of 10 mg/kg or 50 mg/kg daily for 28 days. The concentration of sex hormones, parameters related to glucose and lipid metabolism as well as parameters of antioxidant abilities and oxidative damage were determined in the blood serum. In the ovariectomized control rats, the homeostasis model assessment of insulin resistance (HOMA-IR) index and cholesterol concentration increased, the superoxide dismutase activity increased, and the reduced glutathione concentration decreased. Administration of rosmarinic acid at both doses induced decreases in the fructosamine concentration and HOMA-IR, an increase in the concentration of reduced glutathione, and a decrease in the concentration of advanced oxidation protein products in ovariectomized rats. Moreover, rosmarinic acid at a dose of 50 mg/kg induced a decrease in the total cholesterol and triglyceride concentrations. The results indicate that rosmarinic acid may be useful in the prevention of metabolic disorders associated with estrogen deficiency, however further studies are necessary.

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Section: Discussionmentioning

confidence: 99%

Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats

et al. 2019

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“…(2004) on exposure of blood albumin to oxidative and carbonyl stresses products AOPPs become generated. AOPPs have a pro-inflammatory character, and act as inflammatory mediators that stimulate the recruitment of more neutrophils and monocytes and activate the T-lymphocytes oxidative ignition and dendritic cells (Cakir et al ., 2016).…”

Section: Discussionmentioning

confidence: 99%

Biomolecular changes and cortical neurodegenerative lesions in Trichinella spiralis infected BALB/c mice: a preliminary study elucidating a potential relationship between systemic helminthic infections and idiopathic Parkinson’s

et al. 2018

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SummaryIdiopathic Parkinson’s (IP) is a neurodegenerative disease that is suspected to be due to exposure to infections during early life. Toxoplasmosishas been the only suspected parasitic infection in IP (Celik et al., 2010). Recently, some non-central nervous system bacterial and viral infections have been incriminated in IP (Çamcı & Oğuz, 2016). So in the current study, we tried to explore if the systemic inflammatory reactions triggered by some helminths like Trichinella spiralis can induce Parkinsonian lesions in the brain, especially that the cerebral complications have been reported in 10-20% of Trichinella spiralis infected patients . An experimental study was designed to assess the neurodegenerative and biomolecular changes that may occur in Trichinella spiralis infected BALB/C mice in comparison to rotenone induced PD model and apparently healthy ones. The motor affection was significantly lesser in the Trichinella infected mice than the Parkinson’s model, but when the catalepsy score was calculated (through the grid and bar tests) it was found to be significantly higher in the infected mice than in the healthy ones. A significant increase in the blood advanced oxidative protein products (AOPP), IFN-γ, TGF-β, and brain DNA fragmentation was also detected in the Trichinella spiralis infected mice. After histopathological examination, a significant increase in the cortical apoptotic neurons and Lewy’s body were observed in the Trichinella infected and the rotenone induced Parkinson’s model sections. A significant decrease in the immunohistochemical expression of the tyrosine hydroxylase expression in the brain sections and the ELISA measured dopamine level in the brain homogenate was also reported in the infected mice group. This study findings may collectively suggest that the systemic inflammatory reactions and the oxidative stresses associated with some systemic helminthic infections like trichinellosis are possible to precipitate neurodegenerative lesions and biomolecular changes in the brain , and manifest with IPD later in life.

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“…Our results indicated that although ox-LDL and MDA were higher in post-menopausal women without T2DM, this difference was disappeared in patients with T2DM, either pre-or post-menopausal ( gure1). Yichuan Wen et al reported that ox-LDL mainly increased following menopause in non-diabetic women due to loss of anti-oxidative properties of estrogen after menopause [25] similar to MDA [26]. The interaction analysis showed that T2DM and menopausal status had no signi cant joint effects on ox-LDL and MDA levels.…”

Section: Discussionmentioning

confidence: 98%

Oxidized Low-Density Lipoprotein (Ox-LDL) and Malondialdehyde (MDA) and Menopause: Loss of Protective Effect of Premenopuasl Status in Type 2 Diabetes Mellitus

Arani¹,

Rabizadeh²,

Rajab³

et al. 2020

Preprint

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Background: A network of factors suggested to influence oxidative modification of serum low-density lipoprotein (ox-LDL) concentrations and it plays critical role in diabetic copmlications.This study aimed to assess the joint effect of Type 2 diabetes mellitus (T2DM), gender and menopausal status on ox-LDL and Malondialdehyde (MDA) levels.Material and Method: A total of 594 female and male participants were divided into six groups: 189 postmenopausal women with T2DM, 79 premenopausal women with T2DM, 54 premenopausal women without T2DM, 53 postmenopausal women without T2DM, 186 men with T2DM and 33 men without T2DM. Laboratory and anthropometric measurements, metabolic syndrome (MetS) and the 10-year risk score for atherosclerotic cardiovascular disease (ASCVD) were assessed. Results: Ox-LDL in women with T2DM was three times higher than women without T2DM. However, ox-LDL in men with T2DM was 1.3 times higher than men without T2DM. In non-T2DM participants, postmenopausal women had higher 10-year ASCVD risk score, concentrations of ox-LDL and MDA and higher prevalence of MetS compared to premenopausal women. However, this difference disappeared in participants with T2DM. In The interaction analysis did not show an additional effect of menopausal status and T2DM for ox-LDL and MDA serum levels in female participants (respectively p= 0.310, p= 0.922). In multivariate analysis, TG was independently associated with ox-LDL concentrations (OR: 1.27, p ≤0.001). In T-test analysis, participants with MetS, higher risk of ASCVD had higher levels of ox-LDL.Conclusion: The magnitude of the increase in ox-LDL and MDA levels in women with T2DM was significantly higher than men with T2DM. The differences between pre- and postmenopausal women with and without T2DM in circulating ox-LDL and MDA mostly were dependent on T2DM, regardless of menopausal status. T2DM override the effect of menopausal status, gender and age on ox-LDL and MDA concentrations. Having MetS, increased TG levels and higher 10-year ASCVD risk score suggested to be associated with higher levels of ox-LDL.

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Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

Cited by 24 publications

References 37 publications

Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats

Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats

Biomolecular changes and cortical neurodegenerative lesions in Trichinella spiralis infected BALB/c mice: a preliminary study elucidating a potential relationship between systemic helminthic infections and idiopathic Parkinson’s

Oxidized Low-Density Lipoprotein (Ox-LDL) and Malondialdehyde (MDA) and Menopause: Loss of Protective Effect of Premenopuasl Status in Type 2 Diabetes Mellitus

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