Advanced Soft Palate Cancer: The Clinical Importance of the Parapharyngeal Space

Douglas, Wade G.; Rigual, Néstor R.; Giese, William; Bauer, Joseph E.; Wiseman, Sam M.; Loree, Thom R.; Schwarz, James K.; Alrawi, Sadir; Hicks, Wesley L.

doi:10.1016/j.otohns.2005.03.007

Cited by 15 publications

(10 citation statements)

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“…In this regard, a large number of studies published in recent times have focused on primary radiation therapy as the modality of treatment for these cancers reporting consistently good outcomes 3, 13–16. However, some maintain that these cancers should be grouped together with oral cavity malignancies, and primary surgery should be performed for easily accessible, early‐stage disease 17–20. In the cohort reported here, the large majority of patients (81%) were treated with primary surgery, and almost two thirds of these resections were performed through a transoral approach.…”

Section: Discussionmentioning

confidence: 86%

Surgical management of squamous cell carcinoma of the soft palate: Factors predictive of outcome

et al. 2011

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Section: Discussionmentioning

confidence: 86%

Surgical management of squamous cell carcinoma of the soft palate: Factors predictive of outcome

et al. 2011

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“…Sin embargo, los carcinomas de paladar blando son mayoritariamente P16 negativos [3]. El diagnóstico de los tumores suele ser tardío, ya que, en fases iniciales, son asintomáticos [4]. El tratamiento de elección en los tumores de paladar blando durante años ha sido la radioterapia sola o combinada a quimioterapia [5].…”

Section: Introductionunclassified

Carcinoma de paladar blando. Descripción de una serie de casos

Zabaleta-López

Ramos-Casademont

Gómez-Tomé

et al. 2020

ORL

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Conflicto de intereses: Los autores declaran no tener conflictos de intereses Imágenes: Los autores declaran haber obtenido las imágenes con el permiso de los pacientes Política de derechos y autoarchivo: se permite el autoarchivo de la versión post-print (SHERPA/RoMEO) Licencia CC BY-NC-ND. Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional Universidad de Salamanca. Su comercialización está sujeta al permiso del editor RESUMEN Introducción y objetivo: Describir las características clínicas, anatómicas y el tratamiento quirúrgico, incluyendo las distintas opciones de reconstrucción de los tumores de paladar blando. Descripción: Estudio retrospectivo de 6 pacientes diagnosticados y tratados en el servicio de Otorrinolaringología del hospital San Pedro de Logroño entre los años 2018 y 2019. Discusión: Exponemos los resultados de nuestros pacientes y realizamos una revisión de los tumores de orofaringe localizados en el paladar blando, los detalles anatómicos y técnicas quirúrgicas reconstructivas más utilizadas en el tratamiento quirúrgico de los tumores de paladar blando. Conclusiones: La prevalencia de los tumores de orofaringe ha aumentado en los últimos años a expensas de la infección por el virus del papiloma humano (VPH). Sin embargo, los carcinomas de paladar blando son mayoritariamente P16 negativos. Estos tumores son poco sintomáticos en fases iniciales y es necesario un alto índice de sospecha para evitar diagnósticos tardíos. El desarrollo de la cirugía transoral ha impulsado el tratamiento quirúrgico de los tumores de paladar blando y puede reducir la necesidad de tratamientos complementarios hasta en un 40% de los casos. La reconstrucción se hace necesaria en resecciones mayores del 50%. PALABRAS CLAVE Anatomía; carcinoma; orofaringe; paladar blando; procedimientos quirúrgicos reconstructivos SUMMARY Introduction and objective: To describe clinical and anatomical features, and surgical treatment including several techniques of reconstructive surgery of soft palate carcinomas. Description: We conducted a retrospective study with 5 patients. All of them were diagnosed and treated in our department during 2018 and 2019. Discussion: We present our results and make a review on soft palate tumors pointing out anatomical details and most employed reconstructive surgical techniques for soft palate carcinoma´s removal. Conclusions: The incidence of oropharyngeal carcinoma is increasing worldwide essentially due to increasing prevalence of human

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“…Squamous cell carcinoma of the soft palate (SCCSP) is a relatively rare subtype of oropharyngeal cancer with an annual incidence of 240 to 576 new cases in the United States. 1,2 Any medical or surgical treatment involving the soft palate can significantly diminish quality of life due to disabling functional morbidities involving speech and swallowing. 3 Specifically, the soft palate is a dynamic structure with important roles in maintaining velopharyngeal competence, and disruption can cause functional debility.…”

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confidence: 99%

Squamous Cell Carcinoma of the Soft Palate in the United States: A Population‐Based Study

Chan

Han

Alonso

et al. 2018

Otolaryngol.--head neck surg.

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Objectives To describe the incidence and determinants of survival of patients with squamous cell carcinoma of the soft palate (SCCSP) using the Surveillance, Epidemiology, and End Results (SEER) database. Study Design Retrospective, population-based cohort study of patients. Setting SEER cancer registry. Subjects and Methods Patients from the SEER cancer registry from 1973 to 2015 were used to analyze demographics and survival of SCCSP. Results A total of 4366 cases were identified. The average overall survival (OS) and disease-specific survival (DSS) were 68.7 months and 161.3 months, respectively. Multivariate analysis revealed that male sex, stage, and treatment (hazard ratio [HR] = 0.690, P = .019; HR = 1.73, P < .001; HR = 0.64, P < .001, respectively) were independent determinants of better or worse DSS. Age, stage, and treatment (HR = 1.02, P < .001; HR = 1.49, P < .001; HR = 0.66, P < .001; HR = 0.48, P < .001, respectively) were independent determinants of better or worse OS. For stages I, II, and III, radiation alone and surgery alone have nearly equivalent OS. Patients with stage IV disease who underwent both surgery and radiation had a significantly higher median OS at 50.0 months. Conclusion Radiation alone and surgery alone both have nearly equivalent OS benefit for stages I to III, while surgery and radiation provide the most survival benefit for stage IV disease. The large discrepancy between OS and DSS can be due to significant comorbidities. Future studies should aim to address the determinants of quality-of-life variables that help direct treatment decisions and might indirectly affect survival.

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Advanced Soft Palate Cancer: The Clinical Importance of the Parapharyngeal Space

Abstract: The incidence of PPS recurrences is substantial in advanced-stage soft-palate cancer. PPS recurrences negatively impact survival; without effective salvage techniques for these recurrences or effective adjuvant therapy, poor patient outcomes can be expected.

Cited by 15 publications

References 15 publications

Surgical management of squamous cell carcinoma of the soft palate: Factors predictive of outcome

Surgical management of squamous cell carcinoma of the soft palate: Factors predictive of outcome

Carcinoma de paladar blando. Descripción de una serie de casos

Squamous Cell Carcinoma of the Soft Palate in the United States: A Population‐Based Study

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