Squamous Cell Carcinoma of the Soft Palate in the United States: A Population‐Based Study

Abstract

Objectives To describe the incidence and determinants of survival of patients with squamous cell carcinoma of the soft palate (SCCSP) using the Surveillance, Epidemiology, and End Results (SEER) database. Study Design Retrospective, population-based cohort study of patients. Setting SEER cancer registry. Subjects and Methods Patients from the SEER cancer registry from 1973 to 2015 were used to analyze demographics and survival of SCCSP. Results A total of 4366 cases were identified. The average overall survival (OS) and disease-specific survival (DSS) were 68.7 months and 161.3 months, respectively. Multivariate analysis revealed that male sex, stage, and treatment (hazard ratio [HR] = 0.690, P = .019; HR = 1.73, P < .001; HR = 0.64, P < .001, respectively) were independent determinants of better or worse DSS. Age, stage, and treatment (HR = 1.02, P < .001; HR = 1.49, P < .001; HR = 0.66, P < .001; HR = 0.48, P < .001, respectively) were independent determinants of better or worse OS. For stages I, II, and III, radiation alone and surgery alone have nearly equivalent OS. Patients with stage IV disease who underwent both surgery and radiation had a significantly higher median OS at 50.0 months. Conclusion Radiation alone and surgery alone both have nearly equivalent OS benefit for stages I to III, while surgery and radiation provide the most survival benefit for stage IV disease. The large discrepancy between OS and DSS can be due to significant comorbidities. Future studies should aim to address the determinants of quality-of-life variables that help direct treatment decisions and might indirectly affect survival.

Carcinoma Espinocelular em Palato Mole: Relato de Caso

“…O carcinoma espinocelular em região de palato mole é relativamente raro, e pode diminuir drasticamente a qualidade de vida do paciente por conta das morbidades funcionais incapacitantes envolvendo deglutição e fala, sendo frequentemente doloroso, e oferecendo um pior prognóstico quando comparado a tumores localizados mais anteriormente 17,18,19,20 . O paciente se apresentava com dificuldades de se alimentar por conta do tamanho e localização do tumor, o que contribuiu para a redução de sua imunidade e aumento da morbidade.…”

“…O câncer de palato mole representa cerca de 5-12% das neoplasias malignas de orofaringe e, 70% dos casos, são Carcinoma Espinocelular. Embora sejam mais raros, tumores nessa localização demonstram um comportamento mais agressivo do que em outras partes da cavidade bucal e causam morbidades funcionais incapacitantes significativas na mastigação, deglutição e fala [17][18][19] .…”

Transoral Robotic Surgery for Cancer of the Soft Palate Posterior Surface

“…In the high majority of cases, our patient tumor would have been treated by radiotherapy. 1 The strength of our technique is the realization of an effective surgical treatment for early stage OSCC without use of radiotherapy. The patient who benefited from TORS resection of soft palate tumor avoids the side effects of radiotherapy or the usual complication of open surgery (eg, infection, bleeding, or fistula).…”

Carcinoma de paladar blando. Descripción de una serie de casos

“…Cuando aumentan de tamaño pueden provocar dolor, halitosis, sangrado, rinolalia y trismus por infiltración de las estructuras vecinas como la musculatura pterigoidea [12]. Distintos autores [1,13] ponen de manifiesto que los tumores de paladar blando se diagnostican en fases precoces por la facilidad diagnóstica por la localización. En nuestro caso, el 50% eran localmente avanzados, de acuerdo con otros autores [2,9].…”