Professor Tay Joo-Hwa and Associate Professor Show Kuan-Yeow, for their patience, guidance, and caring support throughout the course of my Ph.D. study. Their valuable expertise, diverse interests, critical thinking, technical skills and insights have been a constant source of inspiration, and encourage me go far. I am especially grateful for Dr. Show, for his consistent and private support after he left from NTU last December. I also extend my thanks to Dr. Chen Xiaoge, an exsupervisor, for helping me to understand molecular biology and to conduct biological experiments. I would like to extend my appreciation to Professor DJ Lee (National Taiwan University) for his enlightening suggestions and expert insight during this research. From analyzing the data in a new light to designing the experiments, his contribution is significant. Sincere thanks go to Mr. David Liang, for providing me with an opportunity of working in his Advanced Clean Energy Center. Much of this work would not have been possible without his enthusiasm, support and belief in me. I acknowledge the help and moral support provided by Dr.