Advanced understanding of genetic risk and metabolite signatures in construction workers via cytogenetics and metabolomics analysis

Ganesan, Raja; Jang, Yoon-Kwan; Suh, Jung-Soo; Vasantha-Srinivasan, Prabhakaran; Kim, Tae-Jin

doi:10.1016/j.procbio.2019.07.016

Cited by 17 publications

(9 citation statements)

References 40 publications

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“…The accumulation of ROS additionally induces the production of numerous cytokines, the activation of immune cells, angiogenesis, and the metastatic process [ 16 ]. Oxidative metabolites, such as acetaldehyde and ROS, produced by alcohol metabolism, can induce epigenetic changes through changes in the metabolism of folate, an essential component of DNA synthesis, and methylation [ 17 , 18 ].…”

Section: Oxidative Stress Formation In Aldmentioning

confidence: 99%

Microbiome-Based Metabolic Therapeutic Approaches in Alcoholic Liver Disease

Hyun

Kim

Yoon

et al. 2022

IJMS

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Alcohol consumption is a global healthcare problem. Chronic alcohol consumption generates a wide spectrum of hepatic lesions, the most characteristic of which are steatosis, hepatitis, fibrosis, and cirrhosis. Alcoholic liver diseases (ALD) refer to liver damage and metabolomic changes caused by excessive alcohol intake. ALD present several clinical stages of severity found in liver metabolisms. With increased alcohol consumption, the gut microbiome promotes a leaky gut, metabolic dysfunction, oxidative stress, liver inflammation, and hepatocellular injury. Much attention has focused on ALD, such as alcoholic fatty liver (AFL), alcoholic steatohepatitis (ASH), alcoholic cirrhosis (AC), hepatocellular carcinoma (HCC), a partnership that reflects the metabolomic significance. Here, we report on the global function of inflammation, inhibition, oxidative stress, and reactive oxygen species (ROS) mechanisms in the liver biology framework. In this tutorial review, we hypothetically revisit therapeutic gut microbiota-derived alcoholic oxidative stress, liver inflammation, inflammatory cytokines, and metabolic regulation. We summarize the perspective of microbial therapy of genes, gut microbes, and metabolic role in ALD. The end stage is liver transplantation or death. This review may inspire a summary of the gut microbial genes, critical inflammatory molecules, oxidative stress, and metabolic routes, which will offer future promising therapeutic compounds in ALD.

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Section: Oxidative Stress Formation In Aldmentioning

confidence: 99%

Microbiome-Based Metabolic Therapeutic Approaches in Alcoholic Liver Disease

Hyun

Kim

Yoon

et al. 2022

IJMS

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“…Metabolomics (also referred as metabonomics or metabolic profiling) gives data from whole-cell responses to NPs which acts as valuable tools for small-molecule (<1500 Da) investigations. Metabolomic profiling of endogenous metabolites is widely used in the study of biochemical pathways (e.g., glycolysis to oxidative phosphorylation) in systems biology [93,[115][116][117]. Metabolome (set of small molecules or metabolites) act as structural building blocks to transform biochemical reactions in every cell.…”

Section: Agnps Currently Applied In Chemical Metabolomics and Suppresmentioning

confidence: 99%

Microcellular Environmental Regulation of Silver Nanoparticles in Cancer Therapy: A Critical Review

Ganesan

Jang

Suh

et al. 2020

Cancers

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Silver nanoparticles (AgNPs) play significant roles in various cancer cells such as functional heterogeneity, microenvironmental differences, and reversible changes in cell properties (e.g., chemotherapy). There is a lack of targets for processes involved in tumor cellular heterogeneity, such as metabolic clampdown, cytotoxicity, and genotoxicity, which hinders microenvironmental biology. Proteogenomics and chemical metabolomics are important tools that can be used to study proteins/genes and metabolites in cells, respectively. Chemical metabolomics have many advantages over genomics, transcriptomics, and proteomics in anticancer therapy. However, recent studies with AgNPs have revealed considerable genomic and proteomic changes, particularly in genes involved in tumor suppression, apoptosis, and oxidative stress. Metabolites interact biochemically with energy storage, neurotransmitters, and antioxidant defense systems. Mechanobiological studies of AgNPs in cancer metabolomics suggest that AgNPs may be promising tools that can be exploited to develop more robust and effective adaptive anticancer therapies. Herein, we present a proof-of-concept review for AgNPs-based proteogenomics and chemical metabolomics from various tumor cells with the help of several technologies, suggesting their promising use as drug carriers for cancer therapy.

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“…The gut microbiota directly yields the metabolome (full set of metabolites) and organic compounds (i.e., ethanol, acetaldehyde, ammonia, etc.). Metabolic compounds and bacterial products (pathogen-associated microbial metabolites) are frequently metabolized in liver cells ( 2 , 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease

et al. 2022

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The gut microbiome and microbial metabolomic influences on liver diseases and their diagnosis, prognosis, and treatment are still controversial. Research studies have provocatively claimed that the gut microbiome, metabolomics understanding, and microbial metabolite screening are key approaches to understanding liver cancer and liver diseases. An advance of logical innovations in metabolomics profiling, the metabolome inclusion, challenges, and the reproducibility of the investigations at every stage are devoted to this domain to link the common molecules across multiple liver diseases, such as fatty liver, hepatitis, and cirrhosis. These molecules are not immediately recognizable because of the huge underlying and synthetic variety present inside the liver cellular metabolome. This review focuses on microenvironmental metabolic stimuli in the gut-liver axis. Microbial small-molecule profiling (i.e., semiquantitative monitoring, metabolic discrimination, target profiling, and untargeted profiling) in biological fluids has been incompletely addressed. Here, we have reviewed the differential expression of the metabolome of short-chain fatty acids (SCFAs), tryptophan, one-carbon metabolism and bile acid, and the gut microbiota effects are summarized and discussed. We further present proof-of-evidence for gut microbiota-based metabolomics that manipulates the host's gut or liver microbes, mechanosensitive metabolite reactions and potential metabolic pathways. We conclude with a forward-looking perspective on future attention to the “dark matter” of the gut microbiota and microbial metabolomics.

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Advanced understanding of genetic risk and metabolite signatures in construction workers via cytogenetics and metabolomics analysis

Cited by 17 publications

References 40 publications

Microbiome-Based Metabolic Therapeutic Approaches in Alcoholic Liver Disease

Microbiome-Based Metabolic Therapeutic Approaches in Alcoholic Liver Disease

Microcellular Environmental Regulation of Silver Nanoparticles in Cancer Therapy: A Critical Review

Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease

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