Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and Arterial Ulcers

Abstract

Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Quality Enhancement Research Initiative.

PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts

“…Multiple treatment modalities using cytokine replacement (16) and transplantation of keratinocytes or fibroblasts are effective in nondiabetic populations (17)(18)(19), but their efficacy in patients with diabetes is diminished as a result of undetermined mechanisms (17).…”

Feasibility of improving platelet-rich plasma therapy by using chitosan with high platelet activation ability

“…Fundamentally, the mechanisms underlying PRP therapy are the molecular and cellular stimulation of normal wound healing responses, similar to those observed during platelet activation (1). However, it is difficult to cure intractable diseases such as diabetic ulcers and decubitus, since the therapeutic effect tend to differ among individuals (2,3). Reviving a wound with impaired healing is unmanageable because standard wound healing methods do not always provide improved healing results.…”

Dressings for treating foot ulcers in people with diabetes: an overview of systematic reviews

“…Following further screening, we included seven of these reviews (Dumville 2012;Game 2012;Hinchliffe 2008b;Mason 1999a;Nelson 2006;O'Meara 2000;Voigt 2012), including one mixed treatment comparison meta-analysis (all findings were produced from a fixedeffect model; Dumville 2012). The remaining 11 reviews were excluded as they were not considered either to be systematic reviews or to be eligible for this overview (Ashton 2004;Bradley 1999;Braun 2014;Brimson 2013;Eddy 2008;Greer 2013;Heyer 2013;Holmes 2013;Jones 2009;Vandamme 2013;Wang 2005); one review is awaiting assessment as we are currently trying to obtained information about the included studies (Tian 2014).…”