Advancement in the Treatment of Osteoporosis and the Effects on Bone Healing

Kushchayeva, Yevgeniya; Пестун, И. В.; Kushchayev, Sergiy V.; Radzikhovska, Nataliia; Lewiecki, E. Michael

doi:10.3390/jcm11247477

Cited by 24 publications

(13 citation statements)

References 216 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The medium age of the population is 50.0 and 50.81% were men. Most of the subjects were obese (median (interquartile range) BMI: 27.59 (24.15–31.47) kg/m 2 ]. Regarding the metabolic syndrome, though the blood pressure was not high (120.67 mm Hg of medium SBP, and 69.33 mm Hg of medium DBP when measured at participation), nearly half of the subjects has a hypertension history (40.14%).…”

Section: Resultsmentioning

confidence: 99%

“…Osteoporosis, with the characteristics of declined bone mass and degraded bone microstructure, is considered a common senile disease that could lead to an increased risk of bone fragility and fracture, and contribute to an increased mortality in patients [ 1 ]. With an estimated 200 million people affected, osteoporosis has been a major global public health concern [ 2 ]. As an essential determinant of bone health, the measurement of bone mineral density (BMD) is a common operational tool for the diagnosis of osteoporosis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association between dietary inflammation index and bone mineral density: results from the United States National Health and nutrition examination surveys

2023

Renal Failure

View full text Add to dashboard Cite

Objective To investigate the associations of dietary inflammation index (DII) with bone density and osteoporosis in different femoral areas. Methods The study population was selected from the National Health and Nutrition Examination Survey (NHANES) with the exclusion criteria of age 18, pregnancy, or missing information on DII, femoral bone marrow density (BMD), estimated glomerular filtration rate (eGFR), and urine albumin-to-creatinine ratio (UACR), or had diseases which may influence systemic inflammation. DII was calculated based on the questionnaire interview of dietary recall within 24 h. Subjects’ baseline characteristics were collected. The associations between DII and different femoral areas were analyzed. Results After applying exclusion criteria, 10,312 participants were included in the study. Significant differences among DII tertiles were found in BMD or T scores ( p < .001) of the femoral neck, the trochanter, the intertrochanter, and the total femur. High DII was associated with low BMDs and T scores in all the femoral areas (all p < .01). Compared to low DII (tertile1, DII < 0.380 as reference), in the femoral neck, the intertrochanter, and the total femur, increased DII is independently associated with increased the possibility of the presence of osteoporosis (OR, 95% CI: 1.88, 1.11–3.20; 2.10, 1.05–4.20; 1.94, 1.02–3.69, respectively). However, this positive association was only observed in the trochanteric area of the non-Hispanic White population after full adjustment (OR, 95% CI: 3.22 (1.18, 8.79)). No significant difference in the association of DII and the presence of osteoporosis were found in subjects with or without impaired kidney function (eGFR < 60 ml/min/1.73 m 2 ). Conclusion High DII is independently related to declined femoral BMD of femoral areas.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between dietary inflammation index and bone mineral density: results from the United States National Health and nutrition examination surveys

2023

Renal Failure

View full text Add to dashboard Cite

show abstract

“…Conversely, strontium-incorporated silica-based glass scaffolds can enhance bone regeneration by inhibiting osteoclast activity (Wei et al 2014). Excessive osteoclast activity during bone formation may lead to the impairment of physiological bone coupling and new osteoporotic bone (Kushchayeva et al 2022). Herein, we demonstrated that Zn- and F-releasing 4% Al-MP glass could suppress osteoclastogenesis (Fig.…”

Section: Discussionmentioning

confidence: 99%

Zinc- and Fluoride-Releasing Bioactive Glass as a Novel Bone Substitute

Kondo,

Otake,

Kakinuma

et al. 2024

J Dent Res

View full text Add to dashboard Cite

Bioglass 45S5, a silica-based glass, has pioneered a new field of biomaterials. Bioglass 45S5 promotes mineralization through calcium ion release and is widely used in the dental field, including toothpaste formulations. However, the use of Bioglass 45S5 for bone grafting is limited owing to the induction of inflammation, as well as reduced degradation and ion release. Phosphate-based glasses exhibit higher solubility and ion release than silica-based glass. Given that these glasses can be synthesized at low temperatures (approximately 1,000°C), they can easily be doped with various metal oxides to confer therapeutic properties. Herein, we fabricated zinc- and fluoride-doped phosphate-based glass (multicomponent phosphate [MP] bioactive glass) and further doped aluminum oxide into the MP glass (4% Al-MP glass) to overcome the striking solubility of phosphate-based glass. Increased amounts of zinc and fluoride ions were detected in water containing the MP glass. Doping of aluminum oxide into the MP glass suppressed the striking dissolution in water, with 4% Al-MP glass exhibiting the highest stability in water. Compared with Bioglass 45S5, 4% Al-MP glass in water had a notably reduced particle size, supporting the abundant ion release of 4% Al-MP glass. Compared with Bioglass 45S5, 4% Al-MP glass enhanced the osteogenesis of mouse bone marrow–derived mesenchymal stem cells. Mouse macrophages cultured with 4% Al-MP glass displayed enhanced induction of anti-inflammatory M2 macrophages and reduced proinflammatory M1 macrophages, indicating M2 polarization. Upon implanting 4% Al-MP glass or Bioglass 45S5 in a mouse calvarial defect, 4% Al-MP glass promoted significant bone regeneration when compared with Bioglass 45S5. Hence, we successfully fabricated zinc- and fluoride-releasing bioactive glasses with improved osteogenic and anti-inflammatory properties, which could serve as a promising biomaterial for bone regeneration.

show abstract

“…The annual cost of osteoporosis fracture prevention and treatment in the United States is expected to exceed $50 billion 20 years from now (4,5). Investigation of risk factors for osteoporosis is an important tool for maintaining bone mass and reducing fracture risk (6). In addition to common laboratory and screening indicators (e.g., blood lipids, body composition, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…Investigation of risk factors for osteoporosis is an important tool for maintaining bone mass and reducing fracture risk ( 6 ). In addition to common laboratory and screening indicators (e.g., blood lipids, body composition, etc.)…”

Section: Introductionmentioning

confidence: 99%

BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES

Zhang

Tan²,

Tan³

2023

Front. Nutr.

View full text Add to dashboard Cite

IntroductionThe mechanism by which socioeconomic status (SES) affects bone mineral density (BMD) remains unknown, and body mass index (BMI) may be a potential mediator. The purpose of this study was to investigate whether BMI mediates the relationship between SES [education level and poverty income ratio (PIR)] and lumbar BMD and the proportion it mediates.MethodsThis study included a total of 11,075 adults from the National Health and Nutrition Examination Survey (NHANES). Lumbar BMD was measured at the lumbar spine by dual-energy X-ray absorptiometry (DXA). Multivariate linear regression and smoothing curve fitting were used to investigate the relationship between SES and lumbar BMD. Mediator analysis was used to investigate the proportion of BMI mediating the association between SES and BMD.ResultsIn the fully adjusted model, there was a positive correlation between SES and BMD (education level: β = 0.025, 95% CI: 0.005, 0.045; PIR: β = 0.007, 95% CI: 0.002, 0.011). Mediation analysis showed that BMI mediated the relationship between PIR, education level, and lumbar BMD with a range of mediation proportions from 13.33 to 18.20%.ConclusionBMI partially mediated the positive association between SES and BMD, and this association may be largely mediated by factors other than BMI.

show abstract

Advancement in the Treatment of Osteoporosis and the Effects on Bone Healing

Cited by 24 publications

References 216 publications

The association between dietary inflammation index and bone mineral density: results from the United States National Health and nutrition examination surveys

The association between dietary inflammation index and bone mineral density: results from the United States National Health and nutrition examination surveys

Zinc- and Fluoride-Releasing Bioactive Glass as a Novel Bone Substitute

BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES

Contact Info

Product

Resources

About