Advancements in SERS‐based biological detection and its application and perspectives in pancreatic cancer

Abstract

Surface‐enhanced Raman spectroscopy (SERS) has become an essential bio‐detection technique. Due to its high sensitivity, good signal specificity, and resistance to photobleaching, SERS has been widely used in biomedical research fields such as molecular imaging, tumor diagnosis, and drug monitoring. This review focuses on the progress of SERS in biomedical applications. We first introduce the basic principle of SERS and the progress of substrate research. Then, we summarize the latest research progress on SERS in drug monitoring, cell and exosome detection, tumor imaging, and detection platforms combining microfluidic and lateral flow technologies. Subsequently, the applied research of SERS in early diagnosis of pancreatic cancer and drug efficacy monitoring is described. Finally, the future development direction and possible challenges of SERS in tumor diagnosis and treatment are proposed.

Recent advances of biocompatible optical nanobiosensors in liquid biopsy: towards early non-invasive diagnosis

“…In localized surface plasmon resonance (LSPR) nanomaterials, charge transfer upon light excitation can occur instantaneously, endowing nanoscale SERS sensors with ultrafast response capabilities that are particularly suitable for the precise real-time monitoring of biological molecular changes. 139 Moreover, Raman scattering spectra resulting from molecular vibrations and rotations are highly specific. Raman spectroscopy can provide fingerprint-like detection information for multi-target, multi-state biological molecules, offering significant advantages in personalized medicine based on fluid diagnostics.…”

Pt/NiFe-LDH hybrids for quantification and qualification of polyphenols

“…Advanced materials function as efficient incorporated tools to construct an integrated platform, considering their tunable physicochemical properties [ 17 ]. To date, noble metal nanomaterials (such as Au, Ag, and Pt) stand out as candidates for improving both colorimetric and LDI MS applications, regarding their localized surface plasmon resonance (LSPR) effects and photo-thermal properties [ 18 , 19 ]. In particular, Pt nanoparticles (NPs) facilitate the movement of interfacial electrons, by reducing the kinetic barrier with a higher metal work function of 5.65 eV ( e.g.…”