Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration

Liu, Nanbo; Ye, Xing; Yao, Bin; Zhao, Mingyi; Wu, Pei‐Chun; Liu, Guihuan; Zhuang, Donglin; Jiang, Haodong; Chen, Xiaowei; He, Yinru; Huang, Sha; Zhu, Ping

doi:10.1016/j.bioactmat.2020.10.021

Cited by 108 publications

(97 citation statements)

References 165 publications

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“…Moreover, electrospinning is a technology that can be up-scaled for industrial application, which provides hope for potential off-shelf scaffolds for cardiac repair [ 130 ]. Bioprinting is a layer-by-layer additive manufacturing technology that allows the user to print biological material with a defined pattern [ 131 ]. Usually, bioinks consist of previously described hydrogels seeded with cells, in which co-factors can be added.…”

Section: Cardiac Organoids To Reproduce the Features Of Human Cardiac Tissuementioning

confidence: 99%

“…Hence, this method gives encouraging results for the production of complex cardiac models. Several other techniques have been developed for bioprinting and have been thoroughly reviewed in a recent article [ 131 ]. Despite all of their advantages, microfabricated scaffolds have limitations: they are less straightforward to make, as they require additional optimization of the material to the chosen technique; they can contain cytotoxic chemical residues; and when the scaffold is fabricated first and the cells are seeded afterwards, it can lead to scarce and inhomogeneous cell infiltration.…”

Section: Cardiac Organoids To Reproduce the Features Of Human Cardiac Tissuementioning

confidence: 99%

“…Bioprinting is a layer-by-layer additive manufacturing technology that allows the user to print biological material with a defined pattern [ 131 ]. Usually, bioinks consist of previously described hydrogels seeded with cells, in which co-factors can be added.…”

Section: Cardiac Organoids To Reproduce the Features Of Human Cardiac Tissuementioning

confidence: 99%

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Cardiac Organoids to Model and Heal Heart Failure and Cardiomyopathies

et al. 2021

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Cardiac tissue engineering aims at creating contractile structures that can optimally reproduce the features of human cardiac tissue. These constructs are becoming valuable tools to model some of the cardiac functions, to set preclinical platforms for drug testing, or to alternatively be used as therapies for cardiac repair approaches. Most of the recent developments in cardiac tissue engineering have been made possible by important advances regarding the efficient generation of cardiac cells from pluripotent stem cells and the use of novel biomaterials and microfabrication methods. Different combinations of cells, biomaterials, scaffolds, and geometries are however possible, which results in different types of structures with gradual complexities and abilities to mimic the native cardiac tissue. Here, we intend to cover key aspects of tissue engineering applied to cardiology and the consequent development of cardiac organoids. This review presents various facets of the construction of human cardiac 3D constructs, from the choice of the components to their patterning, the final geometry of generated tissues, and the subsequent readouts and applications to model and treat cardiac diseases.

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Section: Cardiac Organoids To Reproduce the Features Of Human Cardiac Tissuementioning

confidence: 99%

Section: Cardiac Organoids To Reproduce the Features Of Human Cardiac Tissuementioning

confidence: 99%

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Cardiac Organoids to Model and Heal Heart Failure and Cardiomyopathies

et al. 2021

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“…Skin and bone regeneration gained the most interest of researchers due to their simplicity compared to heart valves, which required specialized structures [ 35 ]. However, with the development in material science and fabrication techniques, particularly the use of 3D printing technologies to print biopolymer-based scaffolds, many specialized and highly accurate scaffolds have been successfully fabricated for the regeneration of most body tissues, including heart-valves [ 68 ].…”

Section: Tissue Scaffolding and Regenerative Medicinementioning

confidence: 99%

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

et al. 2021

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The global transplantation market size was valued at USD 8.4 billion in 2020 and is expected to grow at a compound annual growth rate of 11.5% over the forecast period. The increasing demand for tissue transplantation has inspired researchers to find alternative approaches for making artificial tissues and organs function. The unique physicochemical and biological properties of biopolymers and the attractive structural characteristics of aerogels such as extremely high porosity, ultra low-density, and high surface area make combining these materials of great interest in tissue scaffolding and regenerative medicine applications. Numerous biopolymer aerogel scaffolds have been used to regenerate skin, cartilage, bone, and even heart valves and blood vessels by growing desired cells together with the growth factor in tissue engineering scaffolds. This review focuses on the principle of tissue engineering and regenerative medicine and the role of biopolymer aerogel scaffolds in this field, going through the properties and the desirable characteristics of biopolymers and biopolymer tissue scaffolds in tissue engineering applications. The recent advances of using biopolymer aerogel scaffolds in the regeneration of skin, cartilage, bone, and heart valves are also discussed in the present review. Finally, we highlight the main challenges of biopolymer-based scaffolds and the prospects of using these materials in regenerative medicine.

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“…However, I/R injury remains an important complication duo to additional myocyte death occurs during reperfusion. To promote the myocardial repair and regeneration, some related studied were focused on 3D bioprinting technology [ 2 ], Long Noncoding RNA regulation [ 3 ] or the release of VEGF and BMP9 from injectable alginate based composite hydrogel [ 4 ]. These treatments could be efficient to restore the cardiac function after injury.…”

Section: Introductionmentioning

confidence: 99%