Advances in allergen immunotherapy for asthma

Agache, Ioana; Laculiceanu, Alexandru; Cojanu, Cătălina; Spanu, Daniela; Rogozea, Liliana

doi:10.1097/aci.0000000000000686

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…In 2019, the European Academy of Allergy and Clinical Immunology devised guidelines on the application of house dust mites (HDM) AIT as an add-on treatment for HDM-driven allergic asthma [17]. That therapy has its limitations: it is recommended for controlled or partly controlled allergic asthma.…”

Section: Discussionmentioning

confidence: 99%

Asthma, bronchitis respiratory symptoms, allergies and home environment: how are they related?

Wypych-Ślusarska¹,

Niewiadomska²,

Głogowska-Ligus³

2022

pdia

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Introduction: Home environmental conditions can affect the prevalence of childhood asthma and allergies. Aim: To assess the relationship between the prevalence of childhood asthma, bronchitis, and allergies and the condition of the home environment. Material and methods: In 2018 and 2019, a cross-sectional study on 2932 children from elementary schools in the Silesian Voivodship (Southern Poland) was conducted. The questionnaire was based on the International Study of Asthma and Allergies in Childhood (ISAAC). In order to determine the association between the home environment (presence of moulds, furry pets) and respiratory symptoms and diseases, a logistic regression analysis was performed by calculating the odds ratio (OR), determining p < 0.05 as the level of significance. Results: Asthma risk factors were male sex, heating with solid fuel and presence of moulds. The prevalence of respiratory symptoms, bronchitis, and allergic diseases is statistically more common with the presence of moulds in dwellings. A protective effect of the presence of pets on the prevalence of asthma (OR = 0.77; 95% CI: 0.59-0.99), allergy to pet allergens (OR = 0.59; 95% CI: 0.45-0.76), allergy to house dust mite (OR = 0.70; 95% CI: 0.56-0.87) and wheeze in the last 12 months (OR = 0.70; 95% CI: 0.54-0.91) and ever (OR = 0.85; 95% CI: 0.70-1.02) was observed. Conclusions: The study confirmed the known adverse influence of the presence of moulds and heating with solid fuel on the prevalence of asthma, bronchitis, respiratory symptoms and allergic diseases. The protective influence of pets on the occurrence of the health disorders under study was demonstrated.

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Section: Discussionmentioning

confidence: 99%

Asthma, bronchitis respiratory symptoms, allergies and home environment: how are they related?

Wypych-Ślusarska¹,

Niewiadomska²,

Głogowska-Ligus³

2022

pdia

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“…La AIT específica con alérgenos es útil en la enfermedad respiratoria alérgica 49 y puede ser un tratamiento eficaz para el AA bien controlada, siempre que se haya demostrado una sensibilización mediada por IgE frente a aeroalérgenos comunes que sea clínicamente relevante y se utilicen extractos bien caracterizados y estandarizados 53 . Sin embargo, su uso está contraindicado en el AAG no controlada, ya que pueden tener un mayor riesgo de reacciones adversas graves 54 .…”

Section: Tratamiento Y Manejounclassified

“…En la actualidad existen comparativas indirectas y metaanálisis que pretenden identificar diferencias entre los tratamientos biológicos con anticuerpos monoclonales, pero no disponemos de comparativas directas entre dos biológicos en una misma población 54 , 60 .…”

Section: Tratamiento Y Manejounclassified

Necesidades no cubiertas en asma alérgica grave

Delgado,

Navarro,

Álvarez-Gutiérrez

et al. 2023

Open Respiratory Archives

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A review of allergen immunotherapy in asthma

Caimmi

Démoly

2022

allergy asthma proc

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Asthma is one of the most common chronic diseases worldwide. Besides symptomatic treatments, allergen immunotherapy (AIT) is a possible add-on treatment for asthmatic patients. In case of an immunologically proven allergen-driven mechanism of asthma, AIT represents the only etiologic treatment for allergic symptoms. AIT has proven both its efficacy and effectiveness in reducing asthma symptoms and asthma medications. It is still debated whether its prescription in severe asthmatic patients is allowed and safe. As for uncontrolled asthma, such a condition should be considered temporary, and AIT may be started as asthma becomes at least partially controlled after treatment adjustment. Finally, randomized trials and real-life studies in recent years have proven that AIT could be administered as a preventive strategy to reduce the risk of developing asthma in patients suffering from allergic rhinitis. More studies are needed to provide more precise indications on the role in clinical practice of AIT in asthmatic patients. Nevertheless, present data are already strong enough to highlight its role as a therapeutic option for allergic asthma and as a preventive strategy to stop or at least decelerate the allergic march.

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Advances in allergen immunotherapy for asthma

Cited by 3 publications

References 34 publications

Asthma, bronchitis respiratory symptoms, allergies and home environment: how are they related?

Asthma, bronchitis respiratory symptoms, allergies and home environment: how are they related?

Necesidades no cubiertas en asma alérgica grave

A review of allergen immunotherapy in asthma

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