Advances in biological applications of self-assembled DNA tetrahedral nanostructures

Li, Songhang; Tian, Taoran; Zhang, Tao; Cai, Xiaoxiao; Lin, Yunfeng

doi:10.1016/j.mattod.2018.08.002

Cited by 132 publications

(141 citation statements)

References 147 publications

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“…Recently, DNA nanotechnology has been developed and employed in a variety of fields owing to the extensive biological functions of DNA nanostructures . Tetrahedral framework nucleic acids (tFNAs) are synthesized by four isometric single‐stranded DNAs through a simple, rapid, and reliable process, which have been identified as 3D DNA nanostructures with a stable structure and superior mechanical properties .…”

Section: Introductionmentioning

confidence: 99%

Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing in Vitro and in Vivo

Liu

Zhang

et al. 2019

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Poor post‐traumatic wound healing can affect the normal function of damaged tissues and organs. For example, poor healing of corneal epithelial injuries may lead to permanent visual impairment. It is of great importance to find a therapeutic way to promote wound closure. Tetrahedral framework nucleic acids (tFNAs) are new promising nanomaterials, which can affect the biological behavior of cells. In the experiment, corneal wound healing is used as an example to explore the effect of tFNAs on wound healing. Results show that the proliferation and migration of human corneal epithelial cells are enhanced by exposure to tFNAs in vitro, possibly relevant to the activation of P38 and ERK1/2 signaling pathway. An animal model of corneal alkali burn is established to further identify the facilitation effect of tFNAs on corneal wound healing in vivo. Clinical evaluations and histological analyses show that tFNAs can improve the corneal transparency and accelerate the re‐epithelialization of wounds. Both in vitro and in vivo experiments show that tFNAs can play a positive role in corneal epithelial wound healing.

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Section: Introductionmentioning

confidence: 99%

Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing in Vitro and in Vivo

Liu

Zhang

et al. 2019

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“…They consist of a recognition component (i.e., a probe), a transducer, and a signal amplification device. 124 One challenge in biosensing is facilitating maximum interactions between analytes and probes while preventing agglomeration due to an irregular distribution of probes across a sensing surface. 124 Rationally designed DNA tetrahedra have proven particularly useful for addressing this problem.…”

Section: Biosensingmentioning

confidence: 99%

“…124 One challenge in biosensing is facilitating maximum interactions between analytes and probes while preventing agglomeration due to an irregular distribution of probes across a sensing surface. 124 Rationally designed DNA tetrahedra have proven particularly useful for addressing this problem. DNA tetrahedra are mechanically robust structures that self-assemble rapidly and in nearly quantitative yields from four component strands.…”

Section: Biosensingmentioning

confidence: 99%

High-order structures from nucleic acids for biomedical applications

Hill

Hall

2020

Mater. Chem. Front.

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“…In recent years, many new materials have been used for tissue engineering, such as DNA nanostructures, 9,10 nucleic acids and analogs, 15 nanosheets, 16 carbon nanotubes 17 and sodium montmorillonite film. Synthetic macromolecule materials can be processed into various required shapes.…”

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confidence: 99%

“…Synthetic macromolecule materials can be processed into various required shapes. In recent years, many new materials have been used for tissue engineering, such as DNA nanostructures, 9,10 nucleic acids and analogs, 15 nanosheets, 16 carbon nanotubes 17 and sodium montmorillonite film. 18,19 Therefore, synthetic macromolecule materials are also the most studied and widely used scaffolding materials in tissue engineering.…”

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confidence: 99%

P34HB electrospun fibres promote bone regeneration in vivo

Meng

Jiao

et al. 2019

Cell Proliferation

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Objective Bone tissue engineering was introduced in 1995 and provides a new way to reconstruct bone and repair bone defects. However, the design and fabrication of suitable bionic bone scaffolds are still challenging, and the ideal scaffolds in bone tissue engineering should have a three‐dimensional porous network, good biocompatibility, excellent biodegradability and so on. The purpose of our research was to investigate whether a bioplasticpoly3‐hydroxybutyrate4‐hydroxybutyrate (P34HB) electrospun fibre scaffold is conducive to the repair of bone defects, and whether it is a potential scaffold for bone tissue engineering. Materials and methods The P34HB electrospun fibre scaffolds were prepared by electrospinning technology, and the surface morphology, hydrophilicity, mechanical properties and cytological behaviour of the scaffolds were tested. Furthermore, a calvarial defect model was created in rats, and through layer‐by‐layer paper‐stacking technology, the P34HB electrospun fibre scaffolds were implanted into the calvarial defect area and their effect on bone repair was evaluated. Results The results showed that the P34HB electrospun fibre scaffolds are interwoven with several fibres and have good porosity, physical properties and chemical properties and can promote cell adhesion and proliferation with no cytotoxicity in vitro. In addition, the P34HB electrospun fibre scaffolds can promote the repair of calvarial defects in vivo. Conclusions These results demonstrated that the P34HB electrospun fibre scaffold has a three‐dimensional porous network with good biocompatibility, excellent biosafety and ability for bone regeneration and repair; thus, the P34HB electrospun fibre scaffold is a potential scaffold for bone tissue engineering.

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Advances in biological applications of self-assembled DNA tetrahedral nanostructures

Cited by 132 publications

References 147 publications

Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing in Vitro and in Vivo

Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing in Vitro and in Vivo

High-order structures from nucleic acids for biomedical applications

P34HB electrospun fibres promote bone regeneration in vivo

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