Advances in biomagnetic research using high-<i>T</i><sub>c</sub>superconducting quantum interference devices

Yang, Hong-Chang; Horng, Herng-Er; Yang, Shieh‐Yueh; Liao, Shu

doi:10.1088/0953-2048/22/9/093001

Cited by 15 publications

(4 citation statements)

References 87 publications

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“…Superconducting quantum interference device (SQUID) magnetometers and gradiometers made from the high critical temperature (high-T c ) superconducting material YBa 2 Cu 3 O 7−x (YBCO) are nowadays used in various applications like geophysical exploration [1][2][3], nondestructive evaluation (NDE) and contaminant detection [4][5][6], as well as in biomedical applications, such as magnetocardiography (MCG) [7], magnetoencephalography (MEG) [8][9][10], and biosensing using magnetic nanoparticles [11][12][13]. Thanks to their high critical temperature, high-T c SQUIDs have reduced cooling requirements compared to their low-T c counterparts, which allows for cheaper sensor operation, more compact systems [3], and reduced sensor standoff distance to nearby sources leading to higher signal amplitudes [8,10,14].…”

Section: Introductionmentioning

confidence: 99%

The role of kinetic inductance on the performance of YBCO SQUID magnetometers

Ruffieux

Kalaboukhov

Xie

et al. 2020

Supercond. Sci. Technol.

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Inductance is a key parameter when optimizing the performance of superconducting quantum interference device (SQUID) magnetometers made from the high temperature superconductor YBa 2 Cu 3 O 7−x (YBCO) because lower SQUID inductance L leads to lower flux noise, but also weaker coupling to the pickup loop. In order to optimize the SQUID design, we combine inductance simulations and measurements to extract the different inductance contributions, and measure the dependence of the transfer function V Φ and flux noise SA comparison between two samples shows that the kinetic inductance contribution varies strongly with film quality, hence making inductance measurements a crucial part of the SQUID characterisation. Thanks to the improved estimation of the kinetic inductance contribution, previously found discrepancies between theoretical estimates and measured values of V Φ and S 1/2 Φ could to a large extent be avoided. We then use the measurements and improved theoretical estimations to optimize the SQUID geometry and reach a noise level of S 1/2 B = 44 fT/ √ Hz for the best SQUID magnetometer with a 8.6 mm × 9.2 mm directly coupled pickup loop. Lastly, we demonstrate a method for reliable one-time sensor calibration that is constant in a temperature range of several kelvin despite the presence of temperature dependent coupling contributions, such as the kinetic inductance. The found variability of the kinetic inductance contribution has implications not only for the design of YBCO SQUID magnetometers, but for all narrow linewidth SQUID-based devices operated close to their critical temperature.

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Section: Introductionmentioning

confidence: 99%

The role of kinetic inductance on the performance of YBCO SQUID magnetometers

Ruffieux

Kalaboukhov

Xie

et al. 2020

Supercond. Sci. Technol.

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“…With the rapid development of highly sensitive magnetometers [1,2], these sensors have made great contributions to the * Authors to whom any correspondence should be addressed. measurement of extremely weak magnetic fields, including fundamental physics [3,4], paleomagnetism [5,6] and biomedical science [7,8].…”

Section: Introductionmentioning

confidence: 99%

Experimental studies on the performance of magnetic shields under different magnetization conditions

Yang¹,

Zhang²,

Shi³

et al. 2023

J. Phys. D: Appl. Phys.

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In recent decades, magnetic shields have provided basic experimental environments for the measurements of extremely weak magnetic fields represented by the biological magnetic signal. Excellent shielding performances, including the low residual field and high shielding factor, are necessary to ensure the quality of these weak magnetic signals and avoid the interference of external magnetic field. The magnetic shielding performance of the same device can be affected by the different degaussing and test conditions, which remains systematically studied. In this paper, the experiments with variable magnetization conditions, including different degaussing orders, test fields and environmental fields, are established in a nearly zero-field space to simulate the different situations during measurement. The residual field and shielding factor of the cubic shielding device are tested in these cases. Meanwhile, these shielding performances are analyzed from the perspective of the magnetization state and calculated based on the magnetic properties which are tested and fitted by Jiles-Atherton model. The results show the influence of these different conditions on the shielding performances of the cubic device, consistent with the numerical calculation. Under the same environmental field, the different degaussing order and test field lead to completely different residual field and shielding performance, respectively. The influence of the earth magnetic field on the shielding factor can be ignored due to its tiny equivalent bias field determined by the anhysteretic magnetization curve.

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“…The SQUID-based, low-field NMR/MRI has several advantages: (1) the ease with which it can achieve high spectral resolution [1,2]; (2) the enhancement of the T 1 -weighted imaging without contrast agents [3] and (3) the lesser susceptibility of artifacts compared to that of high magnetic fields [4]. For a review of SQUID-based NMR and MRI, readers may refer to references [5][6][7]. Most SQUID-based NMR and MRI were performed in magnetically shielded rooms (MSR) [8,9].…”

Section: Introductionmentioning

confidence: 99%

Use of a high-T_cSQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate

Huang¹,

Chen²,

Yang³

et al. 2012

J. Inst.

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This study uses a sensitive, high-T c SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T −1 1 . The high-T c SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s −1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s −1 . The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T −1 1 can be used to distinguish cancerous tissues from normal tissues. The high-T c , SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.

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Advances in biomagnetic research using high-T_csuperconducting quantum interference devices

Cited by 15 publications

References 87 publications

The role of kinetic inductance on the performance of YBCO SQUID magnetometers

The role of kinetic inductance on the performance of YBCO SQUID magnetometers

Experimental studies on the performance of magnetic shields under different magnetization conditions

Use of a high-T_cSQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate

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Advances in biomagnetic research using high-Tcsuperconducting quantum interference devices

Cited by 15 publications

References 87 publications

The role of kinetic inductance on the performance of YBCO SQUID magnetometers

The role of kinetic inductance on the performance of YBCO SQUID magnetometers

Experimental studies on the performance of magnetic shields under different magnetization conditions

Use of a high-TcSQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate

Contact Info

Product

Resources

About

Advances in biomagnetic research using high-T_csuperconducting quantum interference devices

Use of a high-T_cSQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate