Use of a high-T_cSQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate

Abstract

This study uses a sensitive, high-T c SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T −1 1 . The high-T c SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s −1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s −1 . The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T −1 1 can be used to distinguish cancerous tissues from normal tissues. The high-T c , SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.

A study of spin–lattice relaxation rates of glucose, fructose, sucrose and cherries using high-T c SQUID-based NMR in ultralow magnetic fields

“…The SQUID shows a field sensitivity of ∼270 fT Hz -1/2 at the proton resonance frequency. Using high-T c SQUID-based NMR/MRI, discrimination of tumors has been demonstrated at ULFs [10,11].…”