Advances in cell membrane-based biomimetic nanodelivery systems for natural products

Zhang, Yifeng; Zhang, Qian; Li, Chunhong; Zhou, Ziyun; Lei, Hui; Liu, Minghua; Zhang, Dan

doi:10.1080/10717544.2024.2361169

Drug Delivery

2024

DOI: 10.1080/10717544.2024.2361169

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Advances in cell membrane-based biomimetic nanodelivery systems for natural products

Yifeng Zhang,

Qian Zhang,

Chunhong Li

et al.

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2024

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Cited by 3 publications

References 152 publications

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Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement

Wu,

Li,

Wang

et al. 2024

Small

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Biomimetic mineralized collagen (BMC) scaffolds represent an innovative class of bone‐repair biomaterials inspired by the natural biomineralization process in bone tissue. Owing to their favorable biocompatibility and mechanical properties, BMC scaffolds have garnered significant attention in bone tissue engineering. However, most studies have overlooked the importance of bioactivity, resulting in collagen scaffolds with suboptimal osteogenic potential. In this review, the composition of the mineralized extracellular matrix (ECM) in bone tissue is discussed to provide guidance for biomimetic collagen mineralization. Subsequently, according to the detailed fabrication procedure of BMC scaffolds, the substances that can regulate both the fabrication process and biological activities is summarized. Furthermore, a potential strategy for developing BMC scaffolds with superior mechanical properties and biological activities for bone tissue engineering is proposed.

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Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement

Wu,

Li,

Wang

et al. 2024

Small

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Lyophilizable Polymer–Lipid Hybrid Nanoparticles with High Paclitaxel Loading

Zheng,

Wu,

Ahmad

et al. 2024

ACS Appl. Nano Mater.

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Lyophilization is a prevalent technique for preparing paclitaxel (PTX) clinical formulations. However, the instability of PTX nanoparticles poses challenges in producing lyophilized formulations. Such an instability involves maintaining stable dispersions and structural integrity during lyophilization. To tackle these issues, flash nanoprecipitation method is employed to prepare highly stable and loaded lyophilizable diPTX-SS nanoparticles, achieving over a month of nanosuspension stability and 91 wt % loading capacity. Furthermore, adjusting the concentrations and stabilizer ratios allows for controlled nanoparticle preparation with surface structures suitable for lyophilization. The hybridization of PLGA-PEG and DSPE-PEG increases the surface PEG layer content, creating a corona-like outer layer that maintains nanoparticle integrity during lyophilization, and ensures excellent redispersibility for postlyophilization without excessive cryoprotectants. Additionally, responsive release behavior, along with in vitro and in vivo experiments, confirms that these lyophilizable hybrid diPTX-SS nanoparticles effectively suppress tumor growth and vascular endothelial proliferation, offering insights for clinical PTX formulation development.

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Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles

He,

Huang,

Cao

et al. 2024

Drug Delivery

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The advancement of drug delivery systems (DDSs) in recent decades has demonstrated significant potential in enhancing the efficacy of pharmacological agents. Despite the approval of certain DDSs for clinical use, challenges such as rapid clearance from circulation, toxic accumulation in the body, and ineffective targeted delivery persist as obstacles to successful clinical application. Blood cell-based DDSs have emerged as a popular strategy for drug administration, offering enhanced biocompatibility, stability, and prolonged circulation. These DDSs are well-suited for systemic drug delivery and have played a crucial role in formulating optimal drug combinations for treating a variety of diseases in both preclinical studies and clinical trials. This review focuses on recent advancements and applications of DDSs utilizing blood cells and their membrane-derived microvesicles. It addresses the current therapeutic applications of blood cell-based DDSs at the organ and tissue levels, highlighting their successful deployment at the cellular level. Furthermore, it explores the mechanisms of cellular uptake of drug delivery vectors at the subcellular level. Additionally, the review discusses the opportunities and challenges associated with these DDSs.

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Advances in cell membrane-based biomimetic nanodelivery systems for natural products

Cited by 3 publications

References 152 publications

Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement

Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement

Lyophilizable Polymer–Lipid Hybrid Nanoparticles with High Paclitaxel Loading

Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles

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