Advances in clinical application of nanoparticle-based therapy for cancer treatment: A systematic review

Ma, Pingchuan; Wang, Guanru; Men, Ke; Li, Chunjie; Gao, Ning; Li, Longjiang

doi:10.1016/j.ntm.2024.100036

Nano TransMed

2024

DOI: 10.1016/j.ntm.2024.100036

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Advances in clinical application of nanoparticle-based therapy for cancer treatment: A systematic review

Pingchuan Ma,

Guanru Wang,

Ke Men

et al.

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Cited by 7 publications

(1 citation statement)

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“…The biocompatibility of nanocarriers is a critical consideration for their application in biomedical field. 19 To assess the safety and efficacy of COPs, their cytotoxicity was first assessed using the standard MTT assay. Results depicted in Fig.…”

mentioning

confidence: 99%

H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Wang,

Liang,

et al. 2024

Chem. Commun.

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mentioning

confidence: 99%

H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Wang,

Liang,

et al. 2024

Chem. Commun.

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Dual‐functional Nanosized Albumin Facilitates CRISPR‐Cas9‐PAR2 to Mitigate Cytokine Storm via TLR4 and Pyroptosis Signaling

Li,

Zheng,

et al. 2024

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Protease‐activated receptor 2 (PAR2) widely modulates various cytokine secretions and inflammatory responses, while excessive cytokine releases and immune hyperactivation may trigger cytokine storm. However, the potential participation of PAR2 in cytokine storm remains elusive. CRISPR‐Cas9 as an efficient gene editing tool can be used for investigating the possible function of PAR2. In this study, albumin‐based nanoparticles (hAlbumin/cgPAR2) to protect and deliver CRISPR‐Cas9 for precise gene editing of PAR2 is constructed. Nanosized albumin largely assisted CRISPR‐Cas9‐PAR2 (cgPAR2) to enter cells via scavenger receptor‐mediated endocytosis, and then triggered potent transfection efficiency, consequently stimulating PAR2 knockout in vitro and in vivo. Apart from delivering CRISPR‐Cas9, nanosized albumin could be colocalized with TLR4 on endosome and promote PAR2 deficiency to attenuate TLR4/NF‐κB signaling, exerting the strong inhibitory effect of albumin in inflammatory responses depending on TLR4. Moreover, PAR2 deficiency induced by hAlbumin/cgPAR2 alleviated ERK/STING/NLRP3 signaling and GSDMD‐mediated pyroptosis, consequently inhibiting cytokine storm. Therefore, this study uncovered dual functions of nanosized albumin in delivering CRISPR‐Cas9 and facilitating PAR2 deficiency to prevent cytokine storm. It also uncovered that the significant role of PAR2 in modulating cytokine storm and provided a potential gene therapy strategy for treating this disease.

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Pan-cancer analysis of IRF1 focusing on prognostic and immunological roles in non-small cell lung cancer

Sun,

Cao,

Wang

et al. 2024

Heliyon

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Advances in clinical application of nanoparticle-based therapy for cancer treatment: A systematic review

Cited by 7 publications

References 71 publications

H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Dual‐functional Nanosized Albumin Facilitates CRISPR‐Cas9‐PAR2 to Mitigate Cytokine Storm via TLR4 and Pyroptosis Signaling

Pan-cancer analysis of IRF1 focusing on prognostic and immunological roles in non-small cell lung cancer

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Advances in clinical application of nanoparticle-based therapy for cancer treatment: A systematic review

Cited by 7 publications

References 71 publications

H2O2-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

H2O2-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Dual‐functional Nanosized Albumin Facilitates CRISPR‐Cas9‐PAR2 to Mitigate Cytokine Storm via TLR4 and Pyroptosis Signaling

Pan-cancer analysis of IRF1 focusing on prognostic and immunological roles in non-small cell lung cancer

Contact Info

Product

Resources

About

H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy