2015
DOI: 10.1007/s40263-015-0237-z
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Advances in CNS Imaging Agents: Focus on PET and SPECT Tracers in Experimental and Clinical Use

Abstract: The physiological functioning of the brain is not well-known in current day medicine and the pathologies of many neuropsychiatric disorders are still not yet fully understood. With our aging population and better life expectancies, it has become imperative to find better biomarkers for disease progression as well as receptor target engagements. In the last decade, these major advances in the field of molecular CNS imaging have been made available with tools such as functional magnetic resonance imaging (fMRI),… Show more

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Cited by 15 publications
(8 citation statements)
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“…To elucidate the neurodegenerative mechanisms, imaging technology has been developed to identify these misfolded and aggregated proteins in living patients. For over a decade, positron emission tomography (PET) imaging has allowed visualization of amyloid plaques with Aβ‐PET tracers, such as Pittsburgh compound B (PIB) among others . Recently, several tau imaging radiotracers have been developed and used in clinical studies .…”
Section: Introductionmentioning
confidence: 99%
“…To elucidate the neurodegenerative mechanisms, imaging technology has been developed to identify these misfolded and aggregated proteins in living patients. For over a decade, positron emission tomography (PET) imaging has allowed visualization of amyloid plaques with Aβ‐PET tracers, such as Pittsburgh compound B (PIB) among others . Recently, several tau imaging radiotracers have been developed and used in clinical studies .…”
Section: Introductionmentioning
confidence: 99%
“…A particular advantage of these techniques is that only tracer quantities of a radiolabeled drug need to be administered for PK and ADME studies, so that they can be performed early (i.e., before phase I trials) in patients [63,64]. For a more detailed description of nuclear imaging techniques and their many applications, the reader is referred to several previous reviews on the topic [58,60,[65][66][67].…”
Section: Application Of Nuclear Imaging In the Context Of Sars-cov-2mentioning
confidence: 99%
“…Beyond ligands that bind to receptors to which drugs are targeted, there are those such as [ 18 F] florbatepir, recently approved by the US Food and Drug Administration (FDA) as a clinical imaging agent, which bind to substances, in this case amyloid, in the brain that can be used to selection of patients for drug trials . Such ligands can also be used to assess drug effects on the substance in question.…”
Section: Biochemicalmentioning
confidence: 99%