Advances in contact printing technologies of carbohydrate, peptide and protein arrays

Voskuhl, Jens; Brinkmann, Jenny; Jonkheijm, Pascal

doi:10.1016/j.cbpa.2013.10.022

Cited by 52 publications

(37 citation statements)

References 57 publications

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“…Binding is usually quantified using fluorescence-based detection systems. Different glycan arrays vary in glycan composition 32 and the mode of glycan immobilization; for example, covalent binding of amine-terminating glycans to N -hydroxysuccinimide (NHS)-activated glass slides 23 or glycan linkage to lipids that are printed on nitrocellulose-coated glass slides (known as neoglycolipid (NGL)-based arrays 25,33,34 ). Although arrays from the different platforms vary in the composition of the glycans on the array, as well as the glycan-coupling method, both types of arrays have been useful in identifying glycan receptors for viruses.…”

Section: Studying Virus–sialic Acid Interactionsmentioning

confidence: 99%

The sweet spot: defining virus–sialic acid interactions

et al. 2014

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Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus–glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus–glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus–glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications.

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Section: Studying Virus–sialic Acid Interactionsmentioning

confidence: 99%

The sweet spot: defining virus–sialic acid interactions

et al. 2014

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“…First, we aimed to demonstrate the patterning of hepatocytes on a glass surface exhibiting a chemical contrast between PLL and PEG. The patterned surface was fabricated by microcontact printing (μCP) of PLL followed by backfilling of the spots with the graft copolymer PLL‐ g ‐PEG (PEG) (Supporting Information Figure S7). These chemically structured surfaces were then exposed to hepatocytes for 24 h and 48 h prior to cell fixation, staining and imaging by optical microscopy.…”

Section: Resultsmentioning

confidence: 99%

Patterned Liposome–Polymer Composite Coatings

et al. 2016

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Engineered biointerphases are crucial for many biomedical applications involving the interaction of (bio)materials with cell and tissue. Providing cues to support cell adhesion/proliferation in form of cargo delivery and/or by providing spatially controlled adhesive patches are important aspects. We demonstrate the assembly of composite films consisting of negatively charged liposomes, poly(dopamine) or cholesterolmodified poly(methacrylic acid) (PMAc) capping layers and (poly(L lysine)/PMAc)x terminating multilayers. We show that hepatocytes adhere to the assembled composite coatings. Their association with fluorescent lipids from the film varies depending on the capping layer and cell adhesion time and was suggested to be an energy dependent process. Further, the incorporation of TX into Ln reduced the number of adhering hepatocytes to the film without terminating multilayers. An exemplary composite coating is patterned and the subsequent site-selective adhesion of hepatocytes is shown. For the first time, composite coatings to be used for substrate-mediated drug delivery with control over the positioning of the adhering cells are shown.

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“…Dip Pen Nanolithography exploits atomic force microscope tips inked with receptor molecules to pattern biological material. Polymer Pen Imprinting uses an array of inked polymer tips typically made by PDMS which are brought into contact with the surface to imprint and moved with a piezoelectric system [74]. Another variation of μCP, namely Lift-up, consists in the deposition of an active material on the substrate on which a soft mold is pressed.…”

Section: Advanced Nil Techniquesmentioning

confidence: 99%

Nanoimprint Lithography: Toward Functional Photonic Crystals

Lova

Soci

2015

Organic and Hybrid Photonic Crystals

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In this chapter we review the use of nanoimprint lithography and its derivative soft-lithography techniques for the fabrication of functional photonic crystals. Nanoimprint is a viable, scalable, and cost-effective solution for large area patterning. While initially it relied primarily on pattern transfer from a rigid mold to a thermally softened polymer by embossing, in the last two decades the process evolved rapidly, giving rise to new technologies that allow direct imprint of functional materials such as conjugated polymers, metals, biological matter, and metal oxides. These advancements generated increasing interest in the use of nanoimprint lithography for the fabrication of photonic structures for light management in optoelectronic devices. After describing standard nanoimprint lithography and its derivative soft-lithography methods, we briefly discuss nanoimprint capabilities and prospects in photonic applications. In particular we review recent implementations of imprinted photonic structures for light management in organic light emitting diodes, solar cells, solid state lasers and sensors.

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Advances in contact printing technologies of carbohydrate, peptide and protein arrays

Cited by 52 publications

References 57 publications

The sweet spot: defining virus–sialic acid interactions

The sweet spot: defining virus–sialic acid interactions

Patterned Liposome–Polymer Composite Coatings

Nanoimprint Lithography: Toward Functional Photonic Crystals

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