Advances in electrochemical sensors based on nanomaterials for the detection of lipid hormone

Zhang, Tingting; Du, Xin; Zhang, Zhenguo

doi:10.3389/fbioe.2022.993015

Cited by 6 publications

(4 citation statements)

References 63 publications

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“…New functional nanomaterials and analytical technologies present a promising window of interest for advancing electrochemical sensor and biosensor platform development. Researchers should keep looking into areas like new electrode materials with increased selectivity and sensitivity, smaller, more wearable sensors, and sensors with immediate usage [191].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Electrochemical Detection of Hormones Using Nanostructured Electrodes

Haroon,

Stine

2023

Coatings

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Hormones regulate several physiological processes in living organisms, and their detection requires accuracy and sensitivity. Recent advances in nanostructured electrodes for the electrochemical detection of hormones are described. Nanostructured electrodes’ high surface area, electrocatalytic activity, and sensitivity make them a strong hormone detection platform. This paper covers nanostructured electrode design and production using MOFs, zeolites, carbon nanotubes, metal nanoparticles, and 2D materials such as TMDs, Mxenes, graphene, and conducting polymers onto electrodes surfaces that have been used to confer distinct characteristics for the purpose of electrochemical hormone detection. The use of aptamers for hormone recognition is producing especially promising results, as is the use of carbon-based nanomaterials in composite electrodes. These materials are optimized for hormone detection, allowing trace-level quantification. Various electrochemical techniques such as SWV, CV, DPV, EIS, and amperometry are reviewed in depth for hormone detection, showing the ability for quick, selective, and quantitative evaluation. We also discuss hormone immobilization on nanostructured electrodes to improve detection stability and specificity. We focus on real-time monitoring and tailored healthcare with nanostructured electrode-based hormone detection in clinical diagnostics, wearable devices, and point-of-care testing. These nanostructured electrode-based assays are useful for endocrinology research and hormone-related disease diagnostics due to their sensitivity, selectivity, and repeatability. We conclude with nanotechnology–microfluidics integration and tiny portable hormone-detection devices. Nanostructured electrodes can improve hormone regulation and healthcare by facilitating early disease diagnosis and customized therapy.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Electrochemical Detection of Hormones Using Nanostructured Electrodes

Haroon,

Stine

2023

Coatings

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“…通过原位再生技术, Wang 等 [23] 解决了传统 MIP 传感器无法反复使用的难题. 目前, 电化学生物传感器已被广泛用于分析蛋白质 [119][120] 、多肽 [107] 、氨基酸 [23,121] 和激素 [122][123] 等低浓度标志物.…”

Section: 电化学生物传感器unclassified

Flexible Electrochemical Sensors and Their Applications in Noninvasive Medical Detection^★

Liang,

Ma,

Duan

et al. 2023

Acta Chimica Sinica

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Electrochemical sensors are widely employed for the detection of substance concentrations owing to their rapid response, high sensitivity, remarkable selectivity, and ease of quantification. With the rapid advancements in flexible electronics technology, electrochemical sensors have been transitioned into flexible and wearable formats, facilitating the in-situ analysis of biological liquids or gases. This breakthrough has opened avenues for portable, noninvasive continuous monitoring of physiological parameters and health status, thereby unveiling vast potential in the realm of intelligent healthcare and medical applications. Building upon these remarkable progressions, this paper primarily focuses on the design and applications of flexible electrochemical sensors tailored specifically for noninvasive medical detection. Firstly, the basic components of flexible electrochemical sensors are elucidated. Subsequently, the working principles of various types of sensors are expounded upon. Furthermore, we systematically review the latest advancements in the detection of pivotal chemical substances in typical biofluids such as sweat, interstitial fluid, tears, saliva, and breath, using flexible electrochemical sensors. Finally, the challenges and opportunities of flexible electrochemical sensors for applications in noninvasive health monitoring and precision medicine are discussed and proposed.

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“…Recently, the human-urine-based detection of E2 for its early diagnosis is gaining more popularity due to its patient-friendly and comfortable assay in comparison with serum-based assays [17][18][19][20][21], despite the fact that the E2 concentration present in human urine is much smaller than that in human serum [22]. As solutions to the aforementioned challenges associated with the limited sensitivity available from existing sensor strategies, attempts have been made with various detection mechanisms, such as plasmonic-nanoparticle-based sensors [23][24][25][26][27], fluorescence sensors [28][29][30][31][32], Raman-based sensors [33][34][35][36][37][38], electrochemical sensors [39][40][41][42][43][44][45][46][47][48][49], enzyme immunosensors [50,51], and others [52][53][54][55][56][57][58][59]. To achieve a limit of detection (LOD) of E2 comparable or lower than 1 pg/mL, most of the ultrahigh-sensitivity E2 sensors have employed signal amplification mechanisms t...…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh-Sensitivity Detection of 17β-Estradiol

Seok,

2024

Chemosensors

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17β-estradiol (E2), a vital female sex hormone, plays a crucial role in female reproductive cycles and secondary sexual characteristics. The quantification of E2 concentration in human blood and urine samples is essential because a deviation from physiological levels of E2 indicates the development of diseases and abnormalities such as precocious puberty, breast cancer, weight gain, abnormal menstruation, osteoporosis, and infertility. In addition, the detection of E2 in food and the environment has gained widespread interest because of its role as an endocrine disruptor (environmental hormone) that can perturb physiological processes. E2 is used as a drug for hormone therapy. Various E2 detection technologies for diagnosing relevant human diseases, drug screening, and environmental monitoring have been demonstrated in studies. In this article, we have reviewed technological strategies developed for E2 detection with ultrahigh sensitivity, with a limit of detection comparable to several pg/mL or lower. We observed that gold nanoparticles (AuNPs) were used as nanoplatforms for signal amplification, which enabled ultrahigh sensitivity in most studies. Signal amplification was facilitated by AuNP characteristics such as the versatility of surface biochemistry, exceedingly large surface-to-volume ratio, surface plasmonic activity, luminescence quenching ability, and biocompatibility. These techniques have been used to detect E2 in food, water, human serum, and urine with ultrahigh sensitivity. We summarize the working principles of E2 detection strategies that allow ultrahigh sensitivity and provide an approach for future work required for the elucidation of practical applications of these technologies.

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Advances in electrochemical sensors based on nanomaterials for the detection of lipid hormone

Cited by 6 publications

References 63 publications

Electrochemical Detection of Hormones Using Nanostructured Electrodes

Electrochemical Detection of Hormones Using Nanostructured Electrodes

Flexible Electrochemical Sensors and Their Applications in Noninvasive Medical Detection^★

Ultrahigh-Sensitivity Detection of 17β-Estradiol

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Advances in electrochemical sensors based on nanomaterials for the detection of lipid hormone

Cited by 6 publications

References 63 publications

Electrochemical Detection of Hormones Using Nanostructured Electrodes

Electrochemical Detection of Hormones Using Nanostructured Electrodes

Flexible Electrochemical Sensors and Their Applications in Noninvasive Medical Detection★

Ultrahigh-Sensitivity Detection of 17β-Estradiol

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Product

Resources

About

Flexible Electrochemical Sensors and Their Applications in Noninvasive Medical Detection^★