Climate change, global warming, stagnant productivity of wheat and food security concerns owing to frequent spells of drought stress (DS) have necessitated finding biologically viable drought-mitigation strategies. A trial was conducted to test two promising wheat cultivars (Ujala-16 and Zincol-16) that were subjected to pre-sowing priming treatments with different doses of ZnO nanoparticles (NPs = 40, 80, 120 and 160 ppm) under 50% and 100% field capacity (FC) conditions. The ZnO NPs were prepared with a co-precipitation method and characterized through X-ray diffraction (XRD) and with a scanning electron microscope (SEM). For comparison purposes, untreated seeds were sown as the control treatment. The response variables included botanical traits (lengths, fresh and dry wrights of root and shoot), chlorophyll (a, b and total) contents, antioxidant and proline contents and nutrients status of wheat cultivars. The results showed that DS significantly decreased all traits of wheat cultivars, while ZnO NPs, especially the 120 ppm dose, remained superior by increasing all botanical traits at 100% FC. In addition, ZnO NPs increased the chlorophyll a (1.73 mg/g FW in Ujala-16 and 1.75 mg/g FW in Zincole-16) b (0.70 mg/g FW in Ujala-16 and 0.71 mg/g FW in Zincole-16) and total chlorophyll content (2.43 mg/g FW in Ujala-16 and 2.46 mg/g FW in Zincole-16) by improving the activity of antioxidant and proline content. Moreover, plant nutrients such as Ca, Mg, Fe, N, P, K, and Zn contents were increased by ZnO NPs, especially in the Zincol-16 cultivar. To summarize, Zincol-16 remains superior to Ujala-16, while ZnO NPs (120 ppm dose under 100% FC) increases the growth and mineral contents of both wheat varieties. Thus, this combination might be recommended to wheat growers after testing further in-depth evaluation of more doses of ZnO NPs.