Advances in Fe-based biodegradable metallic materials

Abstract

This review systematically summarizes recent studies on Fe-based biodegradable metallic materials and discusses these findings in terms of their processing methods, mechanical properties, degradability and biocompatibility.

An In Vitro Corrosion Study of Open Cell Iron Structures with PEG Coating for Bone Replacement Applications

“…The reaction of the Fe 2+ cations with OH − anions results in the formation of ferrous hydroxide (6). Some of the Fe 2+ cations can be oxidized to Fe 3+ ions (7), if oxygen and alkaline pH are present.…”

“…These novel kinds of implants can adapt to the needs of the human body in which they are implanted. Their role is to support initially the formation of the healing injured tissues and subsequently to degrade gradually, while the tissue function is repaired [2][3][4][5][6]. The degradable determined by the material, porosity (morphology, size, and distribution of pores), and density of the created foam [61,62].…”

Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications

“…Using the porous structure with a high surface area can effectively increase the degradation rate of the iron-based alloy [73]. Meanwhile, iron-alloys have better strength and toughness than magnesium alloys and can be applied to cardiovascular stents and bone stents [74,75].…”

Long-term in vitro degradation behaviour of Fe and Fe/Mg2Si composites for biodegradable implant applications

“…Unfortunately, challenges related to the extremely slow degradation rate of currently available Fe-based materials remain unsolved. 6 Recently, researchers have focused on the increase in the degradation rate of Fe-based biodegradable metals (BMs) by modifying their chemical composition, microstructure and surface property. 7 It was proved, that the presence of phases with a difference in corrosion potential from that of the Fe matrix can increase the degradation rate by promoting microgalvanic corrosion.…”

“…6 show typical surface morphologies and corresponding cross sections for PF, and its composites (MM and MX) at 20, 50 and 100 days exposure intervals in modied Hanks' solution.…”