Advances in hymenoptera venom immunotherapy

Bilò, Beatrice M; Bonifazi, F.

doi:10.1097/aci.0b013e3282f1eca5

Cited by 24 publications

(13 citation statements)

References 43 publications

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“…Pięć użądleń pszczoły to dawka toksyczna, 40 może wywołać ciężkie objawy chorobowe, ponad 500 to dawka śmiertelna, ale w przypadku osób uczulonych, wskutek reakcji alergicznej zagrożenie śmiertelne stanowi już jedno użądlenie (7,17,26). Podczas żądlenia pszczoła wprowadza do ciała ofiary 50-140 µg jadu (4). Jad pszczeli ma właściwości niszczenia krwinek czerwonych, a więc wykazuje działanie hemolityczne (10).…”

Section: Discussionunclassified

Clinical and behavioral aspects of bee stings in domestic dog

Karpinski¹,

Goleman²,

Czyzowski³

et al. 2016

Medycyna Weterynaryjna

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The aim of this study was to determine the scale of the phenomenon and the risks resulting from stings of domestic dog by bees. The material consisted of clinical interviews on dog disease history from four veterinary clin-ics. Twenty-six cases of stings were selected, in which the dog owner could positively identify the insect species that had stung a dog (on the basis of the external appearance of a dead bee or the presence of its sting). The select-ed dogs were grouped by sex and age: juveniles – aged up to 12 months and adults – aged more than 12 months. In addition, the grouping took into account the occurrence of pulmonary edema symptoms or lack thereof and the body response. Three types of body response were distinguished: a local reaction (M) in the form of erythema with edema, a large local reaction (MD), and anaphylaxis (pulmonary edema confirmed by X-ray examination). The following blood counts were evaluated: erythrocytes, leukocytes, lymphocytes, hematocrit value, hemoglobin con-centration, segmented neutrophils percentage, MCV, MCH, MCHC, as well as biochemical indices: AP, ALT, AST, creatinine, and BUN. Clinical and behavioral symptoms were analyzed with the use of a survey conducted with a randomly selected group of dog owners. To illustrate the scale of the problem, the survey on bee stings was conducted among 97 dog owners. An analysis of the coefficients of correlation between the values of the above parameters and the age of stung dogs showed that with dog’s age, there was a decrease in AP, lymphocyte and leukocyte levels, and an increase in hemoglobin levels percentage of segmented neutrophils, as well as hematocrit and erythrocyte counts. A statistically significant differ-ence was ascertained in AST, whose values were significantly higher in dogs without pulmonary edema (33.6 U/l ± 14.0) than in the group with edema (22.7 U/l ± 4.6), t (22) = 2.856; p = 0.01. A comparison of the average values of the parameters under analysis for both sexes revealed a significant difference between the average values of hemo-globin, which was significantly higher in males (16.6 g/dl ± 2.6), compared to females (14.1 g/dl ± 2.6), t (24) = 2,156; p = 0.041. The dogs were also classified into two groups according to the type of reaction: a local reaction or a large local reaction. Significantly greater differences were found in the average content of erythrocytes in dogs with a local reaction. Among all respondents, 35% reported their dogs having been stung by insects from the family Hymenoptera. Male dogs were stung twice as often as females, and almost half of the sting cases were dogs older than 4 years. Most of the stung dogs were kept in the backyard, and purebred dogs were stung more frequently than crossbreeds. Half of all cases were stings on the head, and the stung dogs usually reacted by strong hyperkinesia and slight vocalization (one point on a three-point scale).

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Section: Discussionunclassified

Clinical and behavioral aspects of bee stings in domestic dog

Karpinski¹,

Goleman²,

Czyzowski³

et al. 2016

Medycyna Weterynaryjna

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“…Should you treat a patient with CMD and a definite history of bee venom allergy but also weakly positive tests to Vespula venom with both venoms? Two reports [47,49] on fatal sting reactions in patients with mastocytosis and no history of previous SAR to stings address these questions, but cannot give definite answers. Should we treat a patient with CMD and definite history of SAR to stings, but negative diagnostic tests?…”

Section: Mastocytosis and Venom Immunotherapymentioning

confidence: 91%

“…Three to 5 years of VIT induces long-term protection in most HVA patients [14], but in patients with mastocytosis and venom induced anaphylaxis, three fatalities have occurred after VIT discontinuation [2,47]. Therefore, it is generally recommended to continue VIT for life in this situation.…”

Section: Mastocytosis and Venom Immunotherapymentioning

confidence: 99%

Mastocytosis and insect venom allergy

Bonadonna

Zanotti

Müller

2010

Current Opinion in Allergy &Amp; Clinical Immunology

104

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“…There is no doubt about its efficacy in general (2)(3)(4). but it is a matter of discussion how to evaluate the effect of treatment in individual cases (5). Although it is well known that immunotherapy with wasp allergens leads to a variety of specific immunological changes related to wasp venom, there is no distinct immunological parameter that is a sufficiently reliable indicator ol protection after this immunotherapy (6).…”

mentioning

confidence: 98%

Immunotherapy with Wasp Venom is Accompanied by Wide-ranging Immune Responses That Need Further Exploration

Brasch

Maidusch²

2009

Acta Derm Venerol

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Immunotherapy with wasp allergen leads to a variety of specific immunological changes. It is unknown, however, whether unspecific effects also occur, and which parameter shifts might indicate treatment success. Therefore, data of patients who had completed immunotherapy with wasp venom were analysed retrospectively for a change in the following parameters after therapy: threshold of skin tests with wasp venom, total and specific serum IgE, specific serum IgG and IgG4, and binding of IgE and IgG4 to major wasp venom allergens. Reactions to field stings were explored. A significant increase in the skin test threshold and a significant decrease in total serum IgE, specific serum IgE and major wasp allergens binding IgE were found. Concentrations of specific serum IgG and IgG4 increased. Patients with corresponding changes in at least three specific parameters did not report severe reactions to verified field stings after therapy. The marked decrease in total serum IgE indicates that wasp immunotherapy has wide-ranging immunological effects, and it appears reasonable to check combinations of several parameters for treatment control.

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Advances in hymenoptera venom immunotherapy

Abstract: Although there has been progress in the past few years, much remains to be accomplished.

Cited by 24 publications

References 43 publications

Clinical and behavioral aspects of bee stings in domestic dog

Clinical and behavioral aspects of bee stings in domestic dog

Mastocytosis and insect venom allergy

Immunotherapy with Wasp Venom is Accompanied by Wide-ranging Immune Responses That Need Further Exploration

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