Advances in in-situ product recovery (ISPR) in whole cell biotechnology during the last decade

Hecke, Wouter Van; Kaur, Guneet; Wever, Heleen De

doi:10.1016/j.biotechadv.2014.07.003

Cited by 138 publications

(97 citation statements)

References 170 publications

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“…This is understandable due to the steady states and constant removal rates obtainable by such systems; the former ensuring a constant quality product stream from continuous processes. 76 However, the use of this cultivation strategy for PHA production has been limited with only few examples available from the reports in the last few years (Table 3). A major problem for industrial implementation of this technique has been the fear of high chances of microbial contamination, which would result in huge financial losses.…”

Section: Continuous Fermentationmentioning

confidence: 99%

Strategies for Large-scale Production of Polyhydroxyalkanoates

Kaur

Roy

2015

Chem.Biochem.Eng.Q.

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Polyhydroxyalkanoates (PHAs) are biodegradable and biocompatible intracellular polyesters that are accumulated as energy and carbon reserves by bacterial species, under nutrient limiting conditions. Successful large-scale production of PHAs is dependent on three crucial factors, which include the cost of substrate, downstream processing cost, and process development. In this respect, design and implementation of bioprocess strategies for efficient PHA bioconversions enable high PHA concentrations, yields and productivities. Additionally, development of PHA fermentation processes using inexpensive substrates, such as agro-industrial wastes, facilitates further cost reduction, thus benefitting large-scale PHA production. Thus, the aim of this review is to highlight various bioprocess strategies for high production of PHAs and their novel copolymers in relatively large quantities. This review also discusses the application of kinetic analysis and mathematical modelling as important tools for process optimization and thus improvement of the overall process economics for large-scale production of PHAs.

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Section: Continuous Fermentationmentioning

confidence: 99%

Strategies for Large-scale Production of Polyhydroxyalkanoates

Kaur

Roy

2015

Chem.Biochem.Eng.Q.

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“…It can also result in product enrichment, and might thus imply the primary product recovery step. ISPR thus forms an interesting approach to potentially simplify DSP and improve overall economics . In organic acid fermentations, inhibitory effects have been ascribed to both the dissociated and undissociated form of the acids, but the undissociated form is usually more inhibitory .…”

Section: Introductionmentioning

confidence: 99%

Screening of sorbents for recovery of succinic and itaconic acid from fermentation broths

Wever¹,

Dennewald

2017

J of Chemical Tech & Biotech

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BACKGROUND The di‐carboxylic acids succinic acid and itaconic acid are promising building block chemicals that can be produced through fermentation, but the processes would benefit from enhancements in product recovery. While sorption has already been studied to some extent for succinate/succinic acid removal, literature on the potential of sorption for itaconic acid recovery is scarce. This work aimed to screen a range of sorbents and/or resins for their capacity to separate both acids from fermentation broths, envisaging both ex situ and in situ product recovery applications. RESULTS Static batch screening led to a shortlist of four promising products. These were further characterized in terms of dynamic sorption capacity, regenerability, acid recovery, ability to concentrate the product and stability during sorption–desorption cycles. Final tests with real fermentation broth gave unsatisfactory results for succinic acid recovery. For itaconic acid, promising results were obtained both on synthetic solutions and on a real fermentation broth. CONCLUSION While it is doubtful that adsorption will be the process of choice for in situ or ex situ succinic acid recovery, well performing sorbents could be identified for itaconic acid recovery from fermentation broths, offering perspectives for in situ product recovery applications. © 2017 Society of Chemical Industry

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“…A growing tendency towards the use of sustainable resources and production technologies has attracted attention (Van Hecke et al, 2014). Intensive bioprocessing, therefore, has been the subject of many contributions at PI conferences since 1995 (Reay et al, 2013).…”

Section: Bioprocess Intensificationmentioning

confidence: 99%

Process Intensification for Production and Recovery of Biological Products

Vaghari¹,

Eskandari²,

Sobhani³

et al. 2015

American Journal of Biochemistry and Biotechnology

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Bioprocesses are important biological reactions which need several sophisticated methods and equipment to produce many novel and important compounds which some of them are traditionally produced by synthetic chemical reactions. In bioprocesses, the products are often produced in a dilute environment and finally they require a high purity. Because of that, downstream processes are usually included a large number of separation steps. Size and capital costs of the equipment are two main limitations of using bioprocesses at industrial scale. Bioprocess intensification by minimizing, substitution, moderation and simplification of the methods and equipment, drastically leads to sustainable processes. This study looks at intensification of the emerging equipment and operational methods and their advantages to lead smaller and cleaner bioprocess plants which in turn, increases production efficiency and quality and decreases byproducts formation, capital cost and energy consumption.

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Advances in in-situ product recovery (ISPR) in whole cell biotechnology during the last decade

Cited by 138 publications

References 170 publications

Strategies for Large-scale Production of Polyhydroxyalkanoates

Strategies for Large-scale Production of Polyhydroxyalkanoates

Screening of sorbents for recovery of succinic and itaconic acid from fermentation broths

Process Intensification for Production and Recovery of Biological Products

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