Advances in Laboratory Tests for Autoantibodies to Nuclear Antigens in Systemic Rheumatic Diseases

Nakamura, Robert M.; Peebles, Carol; Molden, Daniel P.; Tan, Eng M.

doi:10.1093/labmed/15.3.190

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Cited by 26 publications

(20 citation statements)

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“…A number of autoimmunologic diseases exhibit common serologic characteristics (i.e., the presence of antinuclear antibodies [ANAs]) (8). These antibodies are directed against parts of the cell nucleus and the cytoplasm, and many rheumatic diseases are characterized by the presence of one or more of these ANAs (9).…”

mentioning

confidence: 99%

Serologic markers of autoimmunity in women with polycystic ovary syndrome

Hefler-Frischmuth

Walch

Huebl

et al. 2010

Fertility and Sterility

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mentioning

confidence: 99%

Serologic markers of autoimmunity in women with polycystic ovary syndrome

Hefler-Frischmuth

Walch

Huebl

et al. 2010

Fertility and Sterility

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“…In humans, further determination of the specificity of IIF‐ANA–positive sera is used frequently to characterize the ANA reactivity. A commonly used method for such determination is the Ouchterlony immunodiffusion test 9,10. In ANA‐positive dogs, different immunodiffusion subgroups could be correlated to different ANA subgroups 7,8…”

mentioning

confidence: 99%

Subgroups of canine antinuclear antibodies in relation to laboratory and clinical findings in immune‐mediated disease

Hansson-Hamlin¹,

Lilliehöök²,

Trowald-Wigh³

2006

Veterinary Clinical Pathol

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In dogs with homogeneous IIF-ANA staining, SLE is a probable diagnosis because of the diversity of clinical manifestations and autoantibody reactivity against chromosomal antigens. Dogs with a speckled IIF-ANA pattern may have SLE-related diseases, which, in turn, may be correlated with different immunodiffusion subgroups. These syndromes had overlapping clinicopathologic features, as described for human patients.

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“…Autoantibodies to nuclear antigens (antinuclear antibodies, ANAs) are useful as diagnostic markers for a variety of autoimmune diseases (1)(2)(3)(4)(5)(6). Tests for ANAs are widely used in clinical laboratories and many different reagents and techniques are available.…”

Section: Introductionmentioning

confidence: 99%